Oral glucose load and mixed meal feeding lowers testosterone levels in healthy eugonadal men

Gagliano‐Jucá, Thiago; Li, Zhuoying; Pencina, Karol M.; Beleva, Yusnie M.; Carlson, Olga D.; Egan, Josephine M.; Basaria, Shehzad

doi:10.1007/s12020-018-1741-y

Cited by 21 publications

(17 citation statements)

References 33 publications

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“…T concentrations may also be temporarily decreased during acute illness or due to medication use . Moreover, T may be lowered following ingestion of glucose or food …”

Section: Methodsmentioning

confidence: 99%

European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males

et al. 2020

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Background Evidence regarding functional hypogonadism, previously referred to as ‘late‐onset’ hypogonadism, has increased substantially during the last 10 year. Objective To update the European Academy of Andrology (EAA) guidelines on functional hypogonadism. Methods Expert group of academicians appointed by the EAA generated a series of consensus recommendations according to the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) system. Results The diagnosis of functional hypogonadism should be based on both the presence of clinical symptoms supported by repeatedly low morning fasting serum total testosterone (T) measured with a well‐validated assay, after exclusion of organic causes of hypogonadism. Lifestyle changes and weight reduction should be the first approach in all overweight and obese men. Whenever possible, withdrawal/modification of drugs potentially interfering with T production should be advised. Testosterone replacement therapy (TRT) is contraindicated in men with untreated prostate or breast cancer, as well as severe heart failure. Severe low urinary tract symptoms and haematocrit >48%‐50% represent relative contraindications for TRT. Prostate‐specific antigen and digital rectal examination of the prostate should be undertaken in men >40 years of age before initiating TRT to exclude occult prostate cancer. Transdermal T should be preferred for initiation of TRT, whereas gonadotrophin therapy is only recommended when fertility is desired in men with secondary hypogonadism. TRT is able to improve sexual function in hypogonadal men. Other potential positive outcomes of TRT remain uncertain and controversial. Conclusion TRT can reliably improve global sexual function in men with hypogonadism in the short term. Long‐term clinical benefits, and safety of TRT in functional hypogonadism, remain to be fully documented. Clinicians should therefore explicitly discuss the uncertainties and benefits of TRT and engage them in shared management decision‐making.

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“…T concentrations may also be temporarily decreased during acute illness or due to medication use . Moreover, T may be lowered following ingestion of glucose or food …”

Section: Methodsmentioning

confidence: 99%

European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males

et al. 2020

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“…Testosterone levels show a circadian variation, which persists in ageing men [19]. Likewise, testosterone levels are potentially influenced by food intake [5,20]; hence, serum total testosterone should be measured in fasting conditions and in the morning (between 7.00 and 11.00 hours). Moreover, a confirmatory measurement should always be undertaken in the case of a primary pathological value and certainly before starting any testosterone therapy.…”

Section: Diagnostic Evaluation Of Male Hypogonadismmentioning

confidence: 99%

European Association of Urology Guidelines on Sexual and Reproductive Health—2021 Update: Male Sexual Dysfunction

et al. 2021

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“…A large body of evidence has documented that circulating T levels are substantially decreased (from 14 to more than 30%) if not measured in fasting conditions [86,87]. Hence blood testing for T should be performed in a fasting state which allows to adequately measure also glucose and lipids to detect comorbidities.…”

Section: Recommendation 4: Laboratory Diagnosismentioning

confidence: 99%

Recommendations on the diagnosis, treatment and monitoring of testosterone deficiency in men

Lunenfeld

Mskhalaya²,

Zitzmann

et al. 2021

The Aging Male

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The relative proportional increase of the elderly population within many countries will become one of the most significant social transformations of the twenty-first century and, for the first time in history, persons aged 65 or above outnumbered children under five years of age globally. One in four persons living in Europe and Northern America will be aged 65 or over. One of the goals of ISSAM is to raise awareness of the special health needs of older men. Since a significant number of aging men will eventually become testosterone deficient, the Hypogonadism panel of ISSAM updates its guidelines.

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Oral glucose load and mixed meal feeding lowers testosterone levels in healthy eugonadal men

Abstract: A glucose load or a mixed meal transiently, but significantly, lowers TT levels in healthy, non-diabetic eugonadal men. These findings support the recommendations that measurement of serum testosterone to diagnose androgen deficiency should be performed while fasting.

Cited by 21 publications

References 33 publications

European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males

European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males

European Association of Urology Guidelines on Sexual and Reproductive Health—2021 Update: Male Sexual Dysfunction

Recommendations on the diagnosis, treatment and monitoring of testosterone deficiency in men

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