Oral Glutamine in Preventing Treatment‐Related Mucositis in Adult Patients With Cancer

Sayles, Caitlin; Hickerson, Stephen C.; Bhat, Raksha; Hall, Jacob W.; Garey, Kevin W.; Trivedi, Meghana V.

doi:10.1177/0884533615611857

Cited by 57 publications

(70 citation statements)

References 41 publications

(222 reference statements)

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“…46 Similarly, oral or intravenous glutamine can reduce the severity of mucositis, but clinical evidence for its efficacy in preventing infections is lacking. 47,48 Without any specific interventions, mucosal damage starts to heal just before, or with the recovery of granulocytes in peripheral blood (PB), 49 as neutrophil recruitment to the site of mucosal injury may occur up to a week before recovery of neutrophils in PB. 50,51 Reconstitution of the innate cellular immune system…”

Section: Recovery Of Mucosal Injurymentioning

confidence: 99%

Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection

2016

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Infection is the leading cause of non-relapse mortality after allogeneic haematopoietic cell transplantation (HCT). This occurs as a result of dysfunction to the host immune system from the preparative regimen used prior to HCT, combined with a delay in reconstitution of the donorderived immune system after HCT. In this article, we elaborate on the process of immune reconstitution post-HCT that begins with the innate system and is followed by recovery of adaptive immunity. Simultaneously, we describe how the tempo of immune reconstitution influences the risk of various infections. We explain some of the key differences in immune reconstitution and the consequent risk of infections in recipients of peripheral blood stem cell, bone marrow or umbilical cord blood grafts. Other factors that impact on immune recovery are also highlighted. Finally, we allude to various strategies that are being tested to enhance immune reconstitution post-HCT.

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Section: Recovery Of Mucosal Injurymentioning

confidence: 99%

Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection

2016

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“…For examples, glutamine, a non-essential amino acid was widely studied for its potential protective effect on mucositis, dermatitis and oespahagitis [114][115][116][117] ; pentoxifyline, a methyl xanthine derivative, decreased the risk of radiation toxicity in lung [118] ; benzydamine could prevent and treat oral mucositis [119] ; and sulfasalazine was evaluated for its effects on radiotherapy-induced enteritis [120] . To date, there are still a limited number of chemical RAs clinically used to minimize the severity and duration of toxicities associated with radiotherapy.…”

Section: Ra Its Categoris and Mechanisms Of Functionmentioning

confidence: 99%

Research and Development of Radioprotective Agents: A Mini-Review

Saaya

Katsube

Xie

et al. 2017

International Journal of Radiology

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The research and development (R&D) of radioprotective agents (RAs) have been conducting since seven decades ago, and the safety and protection against undesirable effects of ionizing radiation (IR) has become an important issue especially for the benefit of patients receiving the radiotherapy, in addition to the applications in nuclear industry, military, outer space exploration and accidental exposures. Although the technology advancement makes the radiotherapy a promising better treatment by maximizing the effect of IR to the cancer cells, there are still needs for improvement in minimizing the toxicity to the normal cells. Aiming at providing the new researchers in the radiation protection field with an overall view for R&D of the RAs, this mini-review elucidates in brief a general understanding of the IR and its effects on the cell, the concepts of radiotherapy and therapeutic ratio, the categories of RAs and their mechanisms, and discusses on the strategies and challenge for R&D of the RAs.

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“…β-glucan is a polissacarid complex found in foodstuffs such as mushrooms [11] and oats [12], and is able to modulate immunity, thus maximising interactive potential, both by stimulating the survival of probiotic cultures, and through antitumoral activity [13][14][15][16][17]. In addition, probiotics constitute a group of functional substances closely related to the reduction of the side effects of CT, such as diarrhoea, while contributing to improvements in the immune system by helping to modulate the micro-biotics of the intestines [18][19][20][21].…”

Section: Role Of Nutrition In Cancer Chemotherapymentioning

confidence: 99%

“…In relation to mucositis, glutamine stimulates cicatrisation by strengthening the immune system, thereby aiding the recuperation of oral mucus. In the case of diarrhoea, glutamine is able to regenerate the villi by producing improvements in intestinal function [19][20][21][22][23][24][25].…”

Section: Role Of Nutrition In Cancer Chemotherapymentioning

confidence: 99%

Nutrition and its Important Role in Maintaining an Adequate Immunity during Chemotherapy

Al¹,

Ts²

2017

Gynecol Obstet

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There is a high rate of cancer, particularly gynecological and breast cancers among American women. Chemotherapy is commonly used as a means of treating this disease, but it can cause a range of undesirable side effects. Studies have therefore been undertaken in an attempt to identify complementary forms of treatment which may reduce these side effects, and a number of compounds have produced promising results. Examples of these are the fatty acids omega-3, β-glucan, and glutamine, all of which have been shown to increase immunity to gynaecological cancer, and have brought about improvements in the general clinical state of patients undergoing oncological therapy. However, studies also need to be carried out to increase our understanding of the beneficial properties of particular types of nutritional substances, and of developing diagnostic methods which can detect alterations in the transport of amino-acids to cancerous cells, especially in relation to the metabolic function of glutamine, thus making it easier for medical practitioners to take decisions concerning relevant supplementary nutrition.

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Oral Glutamine in Preventing Treatment‐Related Mucositis in Adult Patients With Cancer

Cited by 57 publications

References 41 publications

Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection

Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection

Research and Development of Radioprotective Agents: A Mini-Review

Nutrition and its Important Role in Maintaining an Adequate Immunity during Chemotherapy

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