Oral Health and Prebiotics

Surana, Khemchand R.; Ahire, Eknath D.; Pawar, Ritesh; Khairnar, Ritesh; Mahajan, Sunil; Kshirsagar, Sanjay J.; Talele, Swati G.; Thombre, Nilima A.; Ahire, Bhavana; Keservani, Raj K.

doi:10.1002/9781394167227.ch11

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…It is particularly rich in fructo-oligosaccharides (FOS) and inulin. FOS are a type of prebiotic with a low caloric content and beneficial effects on health, decreasing blood lipids and glucose levels (Surana et al, 2022). However, these saccharides are rapidly hydrolyzed after harvest, affecting the functional characteristics of yacon.…”

Section: Introductionmentioning

confidence: 99%

Microwave-vacuum drying of pulsed vacuum osmotic dehydration-pretreated Yacon as an alternative for preserving fructo-oligosaccharides

Lopes,

Corrêa,

Petri Júnior

et al. 2024

Ciênc. agrotec.

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Yacon, a perennial plant from the Andean region, is particularly rich in fructo-oligosaccharides (FOS) and inulin. However, these saccharides are rapidly hydrolyzed after harvest, affecting the functional characteristics of yacon. Therefore, a preservation technology such as drying is warranted to preserve the FOS content of yacon products during the off-season. To this end, we dried yacon slices, either untreated or pretreated with pulsed vacuum osmotic dehydration (PVOD), in a microwave vacuum (MWV). PVOD was performed using a sorbitol solution (38 °Brix, 35 °C, and 681 mmHg during the first 10 min). A three-level experimental design with three initial power densities (PDs) of 3.6, 6.3, and 9.9 W.g−1 and three vacuum pressures (VPs) of 0, 300, and 600 mmHg was employed to perform the MWV drying experiments. FOS content, drying kinetics, diffusivity, shrinkage, yacon temperature, and rehydration were investigated. We observed that during PVOD, as microwave PD increased, the drying time, moisture, and water activity decreased. Moreover, an increase in PD positively affected FOS retention, diffusivity, temperature, and shrinkage. Furthermore, VP significantly affected FOS retention in pretreated samples and facilitated drying. In addition, microwaves with a higher PD increased the effective diffusivity and facilitated FOS retention. VP also affected the drying and FOS retention of pretreated samples. In general, yacon browning was observed under all treatment conditions, independent of pretreatment. For osmotically dehydrated samples, processing conditions with a PD of 9.9 W.g−1 and vacuum pressure of 600 mmHg are ideal for drying yacon slices via microwave vacuum, thereby increasing the FOS content by approximately 40%.

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Section: Introductionmentioning

confidence: 99%

Microwave-vacuum drying of pulsed vacuum osmotic dehydration-pretreated Yacon as an alternative for preserving fructo-oligosaccharides

Lopes,

Corrêa,

Petri Júnior

et al. 2024

Ciênc. agrotec.

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“…Many strategies with improved pharmacodynamic effects are now being researched to treat brain diseases (Patil et al, 2023). In order to deliver drugs to the brain, advancements are needed in two primary fields: drug discovery and drug delivery technology (Surana et al, 2022). One cutting-edge technique that may be used to transport medication molecules straight into the brain and has shown to be particularly successful against a number of CNS illnesses is the nanoparticle drug delivery system (NDDS) (Singh et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Development of Almotriptan Malate Biodegradable Nanoparticles Loaded for Treatment of Migraine

Naresh,

Ghugarkar

et al. 2024

Intern. J. Zool. Invest.

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The manner in which a drug is given can have a big effect on how well it works. When taking certain medicines, the best concentration range is where they work best. Doses above or below this range may be harmful or have no effect at all. On the other hand, the slow progress in effectively treating serious illnesses has shown that a more diverse approach is needed to get medicines to where they need to go inside cells. The purpose of this study was to find a way to fix headaches by creating and testing chitosan nanoparticles that contain almotriptan malate and are given through the nose. The current study tried to create a new dosage form of almotriptan malate nanoparticles that are targeted to the brain through the nose using the biodegradable material chitosan and the ionic gelation process. So, new study has successfully moved the water-loving drug almotriptan malate from the nose to the brain by adding it to biodegradable chitosan nanoparticles, which makes them an effective migraine treatment. The study results are useful for plans to use chitosan nanoparticles and the medicine almotriptan malate to make a new kind of medicine delivery system that can help people with headaches.

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“…Focusing on making the drug stay longer in the nasal tissue while making a nasal formulation for desired performance is suggested to ensure effective medicine absorption. It is thought that adding mucoadhesive polymers to nose formulations will make the medicine stay in the body longer and help it work better (Surana et al, 2022;Komu et al, 2023;Jaiswal et al, 2023;Nataraja et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of A Nose-To-Brain Drug-Loaded Microemulsion

Drashti,

Anasuya,

et al. 2024

Intern. J. Zool. Invest.

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The aim of this work was to make an Agomelatine microemulsion that could be given through the nose. Because it is broken down quickly in the first pass, the drug agomelatine has a low absolute absorption of only 5%. The solubility study led to the choice of Tween 80 Capmul MCM as the oil, propylene glycol as the surfactant, and tween 80 Capmul MCM as the cosurfactant. To make microemulsions, water titration was used. The 2:1% W/W mix was used to make the recipe. The microemulsions that were made were tested for visual clarity, viscosity, globule size, and an in vitro diffusion study to characterize them. The best mixture was found by looking at the percentage of oil and Smix as independent variables and the viscosity, globule size, and percentage of drug spread as dependent variables. To learn more about the improved batch, tests were done on its phase separation, globule size, optical clarity, pH, viscosity, zeta potential, drug content, in vitro diffusion, and ex vivo diffusion.

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Oral Health and Prebiotics

Cited by 5 publications

References 13 publications

Microwave-vacuum drying of pulsed vacuum osmotic dehydration-pretreated Yacon as an alternative for preserving fructo-oligosaccharides

Microwave-vacuum drying of pulsed vacuum osmotic dehydration-pretreated Yacon as an alternative for preserving fructo-oligosaccharides

Development of Almotriptan Malate Biodegradable Nanoparticles Loaded for Treatment of Migraine

Development and Evaluation of A Nose-To-Brain Drug-Loaded Microemulsion

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