Oral Health, Antimicrobials and Care for Patients With Chronic Oral Diseases – A Review of Knowledge and Treatment Strategies

Ide, Mark; Karimova, Malika; Setterfield, Jane

doi:10.3389/froh.2022.866695

Cited by 3 publications

(1 citation statement)

References 128 publications

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“…Пациенты с пожилого возраста с ХГП и КПЛ имели сопоставимые значения индекса РМА, отличаясь неудовлетворительным уровнем гигиены. Это согласуются с представлениями об этиологии и патогенезе рассмотренных заболеваний, так как нарушение микробиома полости рта и образование биопленок как ведущий этиологический фактор пародонтита может опосредовать развитие КПЛ за счет локального воспаления СОПР и модуляции аутоиммунных реакций [10].…”

Section: обсуждение полученных данныхunclassified

Neurotrophins and vascular endothelial growth factor in oral fluid of elderly patients: diagnostic value for chronic periodontitis and oral lichen planus

Bazarnyi,

Kopenkin,

Polushina

et al. 2024

Tihookeanskij medicinskij žurnal

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Objective. To evaluate the vascular endothelial growth factor A and brain-derived neurotrophic factor in the oral fluid of mature and elderly patients with chronic periodontitis and oral lichen planus. Materials and methods. The study involved 56 participants. The control group consisted of healthy volunteers aged 18–44 (n=10). The comparison group included relatively healthy elderly people aged 60–74 (n=12). The distinguished groups of patients with age-associated dental diseases included: moderate chronic periodontitis mature patients of 45–59 years (n=10) and elderly patients (n=14), as well as elderly patients with oral lichen planus (n=10). The patients underwent dental examination. The content of neurotrophins and vascular endothelial growth factor A in saliva (BDNF/ NGF beta/ VEGF-A Human ProcartaPlex Simplex Kit, Invitrogen, USA) was determined by the multiparametric fluorescence analysis with magnetic microspheres (xMAP, Luminex 200, USA) in compliance with the manufacturer protocol. Results. The groups reveal no differences in the level of brain-derived neurotrophic factor and nerve growth factor beta. The elderly patients with oral lichen planus were found to obtain the highest angiogenesis factor, which diagnostic value was assessed by ROC-analysis. The test appears moderately accurate (AUC=0.875). Conclusion. Vascular endothelial growth factor A can be considered for laboratory monitoring of elderly patients with oral lichen planus.

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Section: обсуждение полученных данныхunclassified

Neurotrophins and vascular endothelial growth factor in oral fluid of elderly patients: diagnostic value for chronic periodontitis and oral lichen planus

Bazarnyi,

Kopenkin,

Polushina

et al. 2024

Tihookeanskij medicinskij žurnal

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Topical Application of Dexamethasone‐Loaded Core‐Multishell Nanocarriers Against Oral Mucosal Inflammation.

Yapto,

Rajes,

Inselmann

et al. 2024

Macromolecular Bioscience

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Topical treatment of oral inflammatory diseases is challenging due to the intrinsic physicochemical barriers of the mucosa and the continuous flow of saliva, which dilute drugs and limit their bioavailability. Nanocarrier technology can be an innovative approach to circumvent these problems and thus improve the efficacy of topical drug delivery to the mucosa. Core‐multishell (CMS) nanocarriers are putative delivery systems with high biocompatibility and the ability to adhere to and penetrate the oral mucosa. Ester‐based CMS nanocarriers release the anti‐inflammatory compound dexamethasone (Dx) more efficiently than a conventional cream. Mussel‐inspired functionalization of a CMS nanocarrier with catechol further improves the adhesion of the nanocarrier and may enhance the efficacy of the loaded drugs. In the present study, the properties of the ester‐based CMS 10‐E‐15‐350 nanocarrier (CMS‐NC) are further evaluated in comparison to the catechol‐functionalized variant (CMS‐C0.08). While the mucoadhesion of CMS‐NC is inhibited by saliva, CMS‐C0.08 exhibits better mucoadhesion in the presence of saliva. Due to the improved adhesion properties, CMS‐C0.08 loaded with dexamethasone (Dx‐CMS‐C0.08) shows a better anti‐inflammatory effect than Dx‐CMS‐NC when applied dynamically. These results highlight the superiority of CMS‐C0.08 over CMS‐NC as an innovative drug delivery system (DDS) for the treatment of oral mucosal diseases.

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Assessment of the Awareness and Oral Hygiene Practices among Patients with Gum and Periodontal Diseases

Korniichuk,

Hlazunov,

Penskyi

et al. 2024

ijsmr

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The level of awareness and practice of hygiene of the average person with periodontal and periodontal tissue diseases remains low and needs to be strengthened by receiving constant information, monitoring and some training from the dentist. The aim of the research is to assess awareness and practice of oral hygiene in patients with gum and periodontal diseases. Methods: 140 people were divided into two groups: I - control group (CG), relatively healthy individuals (n=40), II - patients with gum and periodontal diseases (n=100), who were interviewed, determined the Simplified Oral Health Index (OHI-S) and periodontal index at the first visit to the dentist and 6 months later. Results: Correct responses too ralhy giene questions differed significantly between groups, with the highest meanin group I and the lowest in group II. There was no statistically significant difference between the groups in termsof frequency of brushing, duration, care products, or brushing techniques. Ingroup I, the OHI-S index corresponded to a satisfactory state of hygiene (1.53 ± 0.08) compared to the control group (0.17 ± 0.01) (Table 4), while the period on talindex corresponded to the presence of gingivitis (0.81 ± 0.03) compared to the control group (0.21 ± 0.09). Conclusions: The importance of careful attention to oral hygiene, the use of various means to reduce inflammation and bleeding gums, and the reduction of dental plaque are important parameters in the prevention of gum and periodontal diseases. Prospects: Further study of awareness and oral hygiene practice with therapy in patients who have gum and periodontal diseases is required.

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Oral Health, Antimicrobials and Care for Patients With Chronic Oral Diseases – A Review of Knowledge and Treatment Strategies

Cited by 3 publications

References 128 publications

Neurotrophins and vascular endothelial growth factor in oral fluid of elderly patients: diagnostic value for chronic periodontitis and oral lichen planus

Neurotrophins and vascular endothelial growth factor in oral fluid of elderly patients: diagnostic value for chronic periodontitis and oral lichen planus

Topical Application of Dexamethasone‐Loaded Core‐Multishell Nanocarriers Against Oral Mucosal Inflammation.

Assessment of the Awareness and Oral Hygiene Practices among Patients with Gum and Periodontal Diseases

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