Oral Health in Breast Cancer Women with Vitamin D Deficiency: A Machine Learning Study

Ferrillo, Martina; Migliario, Mario; Marotta, Nicola; Lippi, Lorenzo; Antonelli, Alessandro; Calafiore, Dario; Ammendolia, Valerio; Lombardo, Fortunato; Renò, Filippo; Giudice, Amerigo; Giudice, Amerigo; Sire, Alessandro de

doi:10.3390/jcm11164662

Cited by 21 publications

(16 citation statements)

References 66 publications

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“…Because of concerns over possible adverse effects of long-term bisphosphonate therapy (i.e., osteonecrosis of the jaw and atypical fractures), the need to continue treatment should be reviewed at regular intervals and the therapeutic treatment should be personalized on patients individual risk [ 149 ]. Indeed, it is crucial that an adequate screening of oral health status through a dentistry evaluation in high-risk subjects is carried out before administering anti-osteoporosis drugs [ 150 , 151 ]. In addition, these drugs might be commonly associated with adverse effects, including gastrointestinal problems, bowel disturbance, headache and musculoskeletal pain [ 152 ].…”

Section: Pharmacological Treatmentsmentioning

confidence: 99%

Pharmacological, Nutritional, and Rehabilitative Interventions to Improve the Complex Management of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease: A Narrative Review

Sire

Lippi

Aprile

et al. 2022

JPM

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Osteoporosis is a highly prevalent condition affecting a growing number of patients affected by chronic obstructive pulmonary disease (COPD), with crucial implications for risk of fragility fractures, hospitalization, and mortality. Several risk factors have been identified to have a role in osteoporosis development in COPD patients, including corticosteroid therapy, systemic inflammation, smoke, physical activity levels, malnutrition, and sarcopenia. In this scenario, a personalized multitarget intervention focusing on the pathological mechanisms underpinning osteoporosis is mandatory to improve bone health in these frail patients. Specifically, physical exercise, nutritional approach, dietary supplements, and smoke cessation are the cornerstone of the lifestyle approach to osteoporosis in COPD patients, improving not only bone health but also physical performance and balance. On the other hand, pharmacological treatment should be considered for both the prevention and treatment of osteoporosis in patients at higher risk of fragility fractures. Despite these considerations, several barriers still affect the integration of a personalized approach to managing osteoporosis in COPD patients. However, digital innovation solutions and telemedicine might have a role in optimizing sustainable networking between hospital assistance and community settings to improve bone health and reduce sanitary costs of the long-term management of COPD patients with osteoporosis.

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Section: Pharmacological Treatmentsmentioning

confidence: 99%

Pharmacological, Nutritional, and Rehabilitative Interventions to Improve the Complex Management of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease: A Narrative Review

Sire

Lippi

Aprile

et al. 2022

JPM

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“…However, there is still a lack of consensus about the precise identification of patients at higher risk, and there are no effective predictive tools to focus resources on rehabilitation plans to prevent BCRL, reducing its disabling consequences in BC survivors [26]. In this scenario, growing attention has been recently raised to machine learning solutions in BC management, with promising implications in developing self-improving technological models to guide clinicians in a precision medicine approach [28]. Interestingly, in 2018, Fu et al [29] realized and validated a real-time diagnostic tool for BCRL, assessing the most common symptoms mentioned by BCRL patients.…”

Section: Introductionmentioning

confidence: 99%

Algorithm-Based Risk Identification in Patients with Breast Cancer-Related Lymphedema: A Cross-Sectional Study

Nascimben

Lippi

Sire

et al. 2023

Cancers

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Background: Breast cancer-related lymphedema (BCRL) could be one consequence of breast cancer (BC). Although several risk factors have been identified, a predictive algorithm still needs to be made available to determine the patient’s risk from an ensemble of clinical variables. Therefore, this study aimed to characterize the risk of BCRL by investigating the characteristics of autogenerated clusters of patients. Methods: The dataset under analysis was a multi-centric data collection of twenty-three clinical features from patients undergoing axillary dissection for BC and presenting BCRL or not. The patients’ variables were initially analyzed separately in two low-dimensional embeddings. Afterward, the two models were merged in a bi-dimensional prognostic map, with patients categorized into three clusters using a Gaussian mixture model. Results: The prognostic map represented the medical records of 294 women (mean age: 59.823±12.879 years) grouped into three clusters with a different proportion of subjects affected by BCRL (probability that a patient with BCRL belonged to Cluster A: 5.71%; Cluster B: 71.42%; Cluster C: 22.86%). The investigation evaluated intra- and inter-cluster factors and identified a subset of clinical variables meaningful in determining cluster membership and significantly associated with BCRL biological hazard. Conclusions: The results of this study provide potential insight for precise risk assessment of patients affected by BCRL, with implications in prevention strategies, for instance, focusing the resources on identifying patients at higher risk.

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“…It’s showed a significant correlation between DMFT and vitamin D levels; the regression machine learning model showed that vitamin D status and the use of dental floss were the most relevant variables in terms of correlation with Filled Permanent Teeth Index (DMFT). Vitamin D deficiency, inadequate use of dental floss have a negative impact on oral health in BC women ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of food and nutrient intake in a population of subjects affected by periodontal disease with different levels of bone mineral density

Guasti¹,

Cianferotti

Pampaloni³

et al. 2023

Front. Endocrinol.

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IntroductionBoth osteoporosis and periodontitis are pathologies characterized by an imbalance in the bone tissue. Vitamin C is an important factor involved in maintaining the health of the periodontium; its deficiency causes characteristic lesions to periodontal tissues such as bleeding and redness of the gums. Among the essential minerals for the health of the periodontium we find instead calcium.Objectives of the studyThe objectives of the proposed study are to study the association between the presence of osteoporosis and periodontal disease. We tried to identify the possible connections between particular dietary patterns and therefore the etiopathogenesis of periodontal disease and secondarily of osteoporosis.Materials and methods110 subjects were recruited in a single-center observational cross-sectional study carried through the collaboration between the University of Florence and the private institute of dentistry Excellence Dental Network based in Florence, suffering of periodontitis, 71 osteoporotic/osteopenic and 39 non-osteoporotic/osteopenic. Anamnestic data and information on eating habits were collected.ResultsThe population showed eating habits that do not meet the intake levels recommended by the L.A.R.N. Regarding the relationship between nutrient intake and plaque index, it appears that in the population, the higher the intake of vitamin C through food, the lower the plaque index value is. This result could reinforce the scientific evidence that there is a protective factor in the onset of periodontal disease by the consumption of vitamin C which to date is still the subject of investigation. In addition, the same type of trend would also have been observed for calcium intake, but a larger sample size would be required to make this effect significant.ConclusionsThe relationship between osteoporosis and periodontitis and the role of nutrition in influencing the evolution of these pathologies still seems to be deeply explored. However, the results obtained seem to consolidate the idea that there is a relationship between these two diseases and that eating habits play an important role in their prevention.

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Oral Health in Breast Cancer Women with Vitamin D Deficiency: A Machine Learning Study

Cited by 21 publications

References 66 publications

Pharmacological, Nutritional, and Rehabilitative Interventions to Improve the Complex Management of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease: A Narrative Review

Pharmacological, Nutritional, and Rehabilitative Interventions to Improve the Complex Management of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease: A Narrative Review

Algorithm-Based Risk Identification in Patients with Breast Cancer-Related Lymphedema: A Cross-Sectional Study

Evaluation of food and nutrient intake in a population of subjects affected by periodontal disease with different levels of bone mineral density

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