Oral health in perimenopausal and early postmenopausal women from baseline to 2 years of follow-up with reference to hormone replacement therapy

Tarkkila, Laura; Furuholm, Jussi; Tiitinen, Aila; Meurman, Jukka H.

doi:10.1007/s00784-008-0190-z

Cited by 18 publications

(25 citation statements)

References 37 publications

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“…We have reported that the sensations of painful mouth or dry mouth were not associated with the use of HT in menopause age women in a questionnaire study on 3,173 women [5]. Neither did we observe any major differences in the oral health status of the women using or not using HT during 2 years of observation [6].…”

Section: Introductionmentioning

confidence: 60%

“…However, in the 1970s, the HT combinations used were different from modern therapy. Finally, it should be emphasized that dental status among the women during the 2-year follow-up stayed fairly stable, and thus, the effect of the number of teeth and gingival and periodontal inflammation did not affect the results [6]. The number of teeth as such associated statistically significantly with salivary protein values.…”

Section: Non-ht N=55mentioning

confidence: 99%

“…Salivary albumin concentration increases in patients systemically ill and/or with mucositis [18][19][20][21]. The study design was a 2-year follow-up study of a cohort of peri-and postmenopausal women invited to a free-ofcharge community-based mammography screening [6].…”

Section: Introductionmentioning

confidence: 99%

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Saliva in perimenopausal and early postmenopausal women. A 2-year follow-up study

et al. 2011

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This study aims to investigate salivary flow and biochemical constituents of menopausal-age women with the hypothesis that women using hormone therapy (HT) might present better saliva values than non-users. Two hundred HT users and 200 non-users were selected at random from a cohort study of 3,173 peri- and postmenopausal women and invited to a 2-year clinical follow-up study. Clinical examination with saliva sampling was made at baseline and 2 years later. Salivary total protein, albumin, and immunoglobulin (Ig) concentrations were analyzed. Final material included 106 consistent HT users and 55 non-users. Backward logistic regression analysis was made to determine the risk factors for higher or lower than medium salivary protein values. No difference was seen in salivary flow rate, total protein, and IgA values between baseline and follow-up measurements or between the groups. Albumin, IgG, and IgM concentrations were significantly lower in the 2-year samples of the HT group when compared with baseline. IgA and IgM values were higher in the non-HT 2-year samples when compared with the corresponding HT samples. The only significant explanatory factor for higher than median salivary albumin concentration was the number of teeth both at baseline and 2 years later. HT possibly improved epithelial integrity since the concentrations of serum components albumin, IgG, and IgM decreased during the follow-up. HT as such does not seem to affect saliva, although it may modify it. The clinical relevance of these results needs to be assessed in future studies.

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Section: Introductionmentioning

confidence: 60%

Section: Non-ht N=55mentioning

confidence: 99%

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Saliva in perimenopausal and early postmenopausal women. A 2-year follow-up study

et al. 2011

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“…Oceniano wydzielanie śliny spoczynkowej i stymulowanej. Po 2 latach nie wykazano statystycznie istotnych różnic między badanymi grupami [14]. Również Asplund i Aberg uważają, że suchość nie zależy od stosowania HTZ.…”

Section: Wp³yw Menopauzy Na Oelinianki I B³onê Oeluzow¹ Jamy Ustnejunclassified

Effect of menopause on salivary glands and oral mucosa

Srebrzyńska-Witek¹,

Koszowski²

2013

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StreszczenieChęć zachowania naturalnego i zdrowego uzębienia przez całe życie człowieka wiąże się z regularnymi wizytami kontrolnymi w gabinecie stomatologicznym oraz poddawaniem się wymaganym procedurom leczniczym. W społeczeństwie rośnie świadomość potrzeby utrzymania zdrowia jamy ustnej, dlatego lekarze stomatolodzy obejmują swoją opieką pacjentów w każdym wieku. Wśród nich liczną grupę stanowią kobiety w wieku około-i pomenopauzalnym. Ze względu na wygaśnięcie wewnątrzwydzielniczej funkcji jajników dochodzi u nich do zmniejszenia stężenia hormonów estrogenowych. Prowadzi to do szeregu implikacji ogólnoustrojowych, włą-czając negatywny wpływ na ślinianki oraz błonę śluzową jamy ustnej. U pacjentek tych lekarze stomatolodzy muszą brać pod rozwagę fakt, że mogą one cierpieć na schorzenia jamy ustnej specyficzne dla tego okresu życia. W niniejszej pracy przedstawiono najczęściej pojawiające się dolegliwości dotyczące jamy ustnej kobiet w wieku około-i pomenopauzalnym. Podczas gdy pojawiające się w przebiegu menopauzy objawy ogólne są powszechnie znane, ciągle niska jest świadomość, że dyskomfort w obrębie jamy ustnej jest również częścią dolegliwości tego okresu. Autorzy przedstawiają aktualny stan wiedzy dotyczący wpływu niedoboru estrogenów oraz ich suplementacji na ślinianki oraz błonę śluzową jamy ustnej u kobiet w wieku około-i pomenopauzalnym. Szczególną uwagę zwrócono na objawy związane z nieprawidłowym nawilżeniem błony śluzowej jak również pojawiającym się najczęściej w tym wieku zespołem piekących ust. Autorzy przedstawili także metody terapii wymienionych dolegliwości.Słowa kluczowe: niedostateczne wydzielanie śliny, zespół piekących ust, menopauza. SummaryPreserving natural and healthy dentition till the end of life is strongly connected with regular control visits at the dentist's surgery and following therapeutic procedures that may be found necessary. Today's society develops an awareness of the necessity to preserve good health of the oral cavity. Therefore, dentists attempt to provide medical care to the patients of all ages, including menopausal women. Women at the perimenopausal or post-menopausal age often experience a decrease in estrogenic hormone concentration due to discontinued endocrinological activity of the ovaries. This leads to a number of systemic implications, including the negative effect on salivary glands and oral mucosa. It is important to keep in mind that such patients may suffer from oral diseases specific to their age. This paper presents most common oral diseases that occur in women at the menopausal or perimenopausal age. While the systemic aspects of menopause are well documented, the awareness of oral discomfort as a part of menopausal complaints is still low. The authors present the current state of knowledge on how deficiency or supplementation of estrogens can affect salivary glands and oral mucosa in perimenopausal and post-menopausal women. Particular attention is paid to symptoms resulting from abnormal lubrication of oral mucosa or burning mouth syndrome, the la...

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“…However, studies of whether salivary secretion is increased by hormone replacement therapy have yielded inconsistent results (11)(12)(13)(14). Women comprised 73.7% of patients at a xerostomia clinic at Niigata University Medical and Dental…”

Section: The Present Condition Of Outpatient Clinics For Womenmentioning

confidence: 99%

Questionnaire Survey on Oral Symptoms of Menopausal Women and Cooperation between Doctors and Dentists

et al. 2013

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Objective: Xerostomia, temporomandibular disorder, and periodontal disease are frequently seen in menopausal women. However, few studies have reported the prevalence of oral symptoms during menopause or the cooperation between doctors at outpatient clinics for women and dentists. The purpose of this study was to investigate the frequency of oral symptoms and the cooperation between doctors at outpatient clinics for women and dentists.Methods: A questionnaire was sent to 380 outpatient clinics for women in Japan. The questionnaire included characteristics for the person completing it, staff structure, cooperation with medical specialists, the existence of oral symptoms, details of these symptoms, cooperation with dentists, and space for free responses.Results: The survey response rate was 57.9% (220 of 380 institutions). Most respondents (81.6%) thought that female sex hormones influenced the mouth, and 79.4% had encountered oral symptoms. The most frequently encountered symptoms were oral dryness, taste disorder, and burning sensation of the mouth. The necessity of cooperation between doctors and dentists was recognized by 63.1%. Staff that recognised the influence of female hormones on the mouth were significantly more likely than others to acknowledge the importance of cooperation (p < 0.01). However, as only half of the staff had referred patients to a dental clinic, it seems possible that patients whose symptoms could have been alleviated by dentists were not appropriately managed. Conclusion: Although oral symptoms can relate to menopause, the cooperation between doctors and dentists is poor. Improved cooperation may relieve not only oral complaints but also systemic menopausal symptoms.

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Oral health in perimenopausal and early postmenopausal women from baseline to 2 years of follow-up with reference to hormone replacement therapy

Cited by 18 publications

References 37 publications

Saliva in perimenopausal and early postmenopausal women. A 2-year follow-up study

Saliva in perimenopausal and early postmenopausal women. A 2-year follow-up study

Effect of menopause on salivary glands and oral mucosa

Questionnaire Survey on Oral Symptoms of Menopausal Women and Cooperation between Doctors and Dentists

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