Oral health of children undergoing allogeneic bone marrow transplantation

Lucas, Victoria; Roberts, GJ; Beighton, David

doi:10.1038/sj.bmt.1701415

Cited by 23 publications

(19 citation statements)

References 17 publications

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“…2,24 Berkowitz 25 noted histopathologic changes in the minor salivary glands and resultant xerostomia in all patients in his study who had chronic GVHD. Other researchers have also noted xerostomia after BMT, 2,[26][27][28] and this effect has been linked to an increase in the incidence of dental caries.…”

Section: Discussionmentioning

confidence: 99%

Dental abnormalities after pediatric bone marrow transplantation

Vaughan

Rowland

Tong

et al. 2005

Bone Marrow Transplant

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Summary:Our purpose was to describe the types and frequencies of altered dental development in pediatric patients following bone marrow transplantation (BMT). A retrospective review of the medical records and panoramic radiographs of all patients who underwent BMT at St Jude Children's Research Hospital between 1990 and 2000, for whom pre-BMT and post-BMT dental examination and panoramic radiography records were available, is presented. All patients were treated on institutional protocols. We recorded patient demographics and radiographic evidence of microdontia, hypodontia, taurodontia, root stunting, caries, enamel pearls, dental restorations/extractions and pulpal calcification. The 99 patients identified (52 males, 47 females) had a median age of 13.5 years (range, 3.4-25.9 years) at the time of BMT. In all, 73 were Caucasian, 15 were African-American, and 11 were of other races. The frequency of radiographically evident root stunting in permanent teeth was significantly increased after BMT (Po0.001), but there was no significant change in the frequency of other dental abnormalities after BMT. Dental abnormalities are prevalent in survivors of childhood BMT, but only root stunting appeared to progress with BMT. Bone Marrow Transplantation (2005) 36, 725-729.

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Section: Discussionmentioning

confidence: 99%

Dental abnormalities after pediatric bone marrow transplantation

Vaughan

Rowland

Tong

et al. 2005

Bone Marrow Transplant

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“…Dietary factors, such as a highcarbohydrate diet, and difficulty with oral hygiene because of mucositis may also contribute to the risk of caries. 14,21 A decrease in the elasticity of the perioral tissues has also been Table 1 Demographics and dental maturation of 259 patients who underwent dental radiography prior to BMT Dental abnormalities before pediatric BMT MD Vaughan et al noted in patients after BMT, which may increase the risk of dental complications by reducing access to the oral cavity. 2,22 Berkowitz 23 noted histopathologic changes in the minor salivary glands and resultant xerostomia in all patients in his study who developed chronic GVHD.…”

Section: Discussionmentioning

confidence: 99%

Dental abnormalities in children preparing for pediatric bone marrow transplantation

Vaughan

Rowland

Tong

et al. 2005

Bone Marrow Transplant

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Summary:The purpose of our study was to describe the types and frequencies of altered dental development in pediatric patients preparing for bone marrow transplantation (BMT). Retrospective review of the medical records and panoramic radiographs of all patients who underwent BMT at St Jude Children's Research Hospital between 1990 and 2000 for whom pre-BMT dental examination and panoramic radiography records were available. All patients were treated on institutional protocols. We recorded patient demographics and radiographic evidence of microdontia, hypodontia, taurodontia, root stunting, caries, enamel pearls, and pulpal calcifications. The 259 patients identified (150 male and 109 female) had a median age of 12.82 years (range, 3.18-25.93 years) at the time of BMT. In total, 203 were Caucasian, 38 were African-American, and 18 were of other races. In all, 150 (57.9%) had abnormal dentition. The most common dental abnormalities were caries (n ¼ 84), pulpal calcifications (n ¼ 34), and dental extractions (n ¼ 33). Developmental abnormalities occurred less frequently: taurodontia (n ¼ 8), hypodontia (n ¼ 10), microdontia (n ¼ 11), and root stunting (n ¼ 11). Dental abnormalities are prevalent in children undergoing BMT. Pre-transplant oral hygiene and dental examination should be standard care in order to minimize potential sites of infection.

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“…Os dentes parcialmente irrompidos que possam causar pericoronarite devem ser extraídos e recomenda-se um período de duas semanas para reparação tecidual antes de começar o condicionamento. Todos os pacientes em preparo para TCTH e seus cuidadores devem ser educados quanto à importância de manter boa higiene bucal e assim reduzir os riscos de infecção e facilitar a recuperação da mucosite (GOLDMAN, 2006;YAMAGATA et al, 2006;YAMAGATA et al, 2011;GURGAN et al, 2012; A escovação efetiva reduz a população bacteriana e soluções com flúor reduzem a incidência de cáries (LUCAS et al, 1998). As recomendações para boa higiene bucal incluem o uso de enxaguatórios bucais com bicarbonato de sódio, uso de dentifrícios contendo flúor, escovação com escova extra macia ou esponjas (quando a escova não é tolerada), adequação da dieta para uma dieta menos cariogênica, uso de fio dental e remoção dos aparelhos ortodônticos com mantenedores de espaço até a recuperação da mucosite bucal.…”

Section: O Paciente Em Preparo Para Tcthunclassified

“…O preparo odontológico consiste orientação de higiene bucal e eliminação de possíveis focos de infecção e trauma pelo menos 10 dias antes do início da quimioterapia (LUCAS et al, 1998;GRABER et al, 2001;YAMAGATA et al, 2006;BRENNAN et al, 2008;DUREY et al, 2009;TOMBLYN et al, 2009;YAMAGATA et al, 2011;GURGAN et al, 2012).…”

Section: Rccunclassified

“…Doenças bucais pré-existentes são reservas de microrganismos e são fatores de risco para infecções locais e sistêmicas em pacientes sob preparo para TCTH (DA SILVA SANTOS et al, 2010). Entre as alterações estomatológicas mais frequentes estão: gengivite, acúmulo de biofilme, cálculo dentário, periodontite com bolsas profundas e perda significativa de osso alveolar, alta atividade de cárie, redução de fluxo salivar, restaurações com infiltrações necessitando de retratamento, lesões periapicais, raízes residuais, dentes parcialmente irrompidos, mucosite, dor relacionada à articulação têmporo-mandibular, infecções oportunistas por fungos e vírus, infiltrado leucêmico gengival, petéquias, equimoses, língua saburrosa, úlceras traumáticas infectadas, erosão dental, hiperplasia ou hipertrofia gengival, alterações oclusais e na formação dos dentes após quimioterapia na infância (LUCAS et al, 1998;GRABER et al, 2001;MELKOS et al, 2003;VAUGHAN et al, 2005b;YAMAGATA et al, 2006;BRENNAN et al, 2008;DA SILVA SANTOS et al, 2008;DUREY et al, 2009;BOER et al, 2010;HONG et al, 2010;LAAKSONEN et al, 2011;PALMASON et al, 2011;GURGAN et al, 2012;HERNANDEZ-FERNANDEZ et al, 2012).…”

Section: Introductionunclassified

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Alterações estomatológicas de pacientes em preparo para transplante de células-tronco hematopoiéticas

Araújo¹

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disponibilidade, por abrir meus olhos para uma nova e dinâmica Odontologia, me levando a questionar e aprender a desaprender conceitos e protocolos. Agradeço as oportunidades concedidas, as ocasiões em que trabalhamos juntos, os exemplos de dedicação familiar e profissional e o esmero no cuidado com os pacientes.Um verdadeiro educador, que transmite muito mais que informação científica. (61%) men and 39 (39%) women with a median age of 39 years. The most frequent underlying diseases were acute lymphoblastic leukemia (20%) and acute myeloid leukemia (19%). It was found that 45% of patients had some stomatological alterations. The most prevalent were tongue coating, petechiae, bruising and dry lips. AGRADECIMENTOSPeriodontal disease was found in 62% of patients. The most common manifestations were gingival bleeding among young patients and the more severe forms of periodontitis occurred after 35 years. The caries activity was high (DMFT=14.04), only 09 patients were caries free and 14% of patients had indication for extraction.The overall mean of OHIP-14 was very low (4.62), however there was correlation with the presence of severely compromised teeth due to caries and periodontal disease (p<0.05), indicating a significant impact on quality of life. The most impacting factors were caries activity (p<0.05), restorations with caries (p<0.05) and edentulism (p<0.05). In severe cases with indication for extraction, the impact was significant in psychological distress (p<0.05), psychological incapacity (p<0.01) and deficiency (p<0.01), the greatest degree of impairment of quality of life. We conclude that patients referred for HSCT have several stomatological alterations. Only the cases of aplastic anemia have oral manifestations of primary disease. However, the frequency of gingivitis, periodontitis, and caries activity were high, revealing shortage in dental support during the patient preparation in their hometowns. The impact of oral health problems on quality of life is weak, but in severe cases there is psychological impairment.

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Oral health of children undergoing allogeneic bone marrow transplantation

Cited by 23 publications

References 17 publications

Dental abnormalities after pediatric bone marrow transplantation

Dental abnormalities after pediatric bone marrow transplantation

Dental abnormalities in children preparing for pediatric bone marrow transplantation

Alterações estomatológicas de pacientes em preparo para transplante de células-tronco hematopoiéticas

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