ObjectivesPatient perception and satisfaction with dentures are important indicators in prosthodontic treatment. This study aimed to compare patients' satisfaction with VertexThermosens dentures versus conventional acrylic dentures during a 12‐month study period.Material and MethodsThis randomized study involved 60 participants aged between 45 and 80 with representation of both sexes. The patients were divided into two groups: The first group (experimental group), which had complete dentures from VertexThermosens base material included 30 participants. The second group (control group), which had complete dentures from convectional rigid acrylic base material, included 30 participants. Patient satisfaction with the dentures was assessed in each of the two Vertex/Acrylic groups through a specially created questionnaire of five questions with a five‐point Likert scale of possible answers (0 = never; 1 = rarely; 2 = occasionally; 3 = often; and 4 = very often).ResultsAfter 12 months, intergroup comparison with Mann–Whitney U Test related to Q2 (p = 0.193), Q3 (p = 0.960), Q4 (p = 0.317), Q5 (p = 1.000) patient satisfactions indicated that there was no significant difference between the two groups (Vertex/Acrylic), except Q1 (p = 0.010) question, Vertex group was more satisfied. The results regarding the patients of both groups (Vertex/Acrylic) showed that after 12 months of wearing the denture, the satisfaction level regarding to all questions increased, except Q5‐question for Vertex group, where the difference was not significant due to the already achieved maximum satisfaction at zero time.ConclusionBased on the findings of this clinical study, it can be concluded that higher satisfaction is seen in patients rehabilitated with VertexThermosens dentures than with conventional rigid acrylic dentures.