Oral high-calorie, low-protein supplements in a Parkinson's disease patient: A case report

Barichella, Michela; Madio, C.; Cassani, E.; Magris, Cecilia; Pezzoli, Gianni

doi:10.1002/mds.23373

Cited by 6 publications

(5 citation statements)

References 7 publications

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“…Moreover, the increased body weight can also be explained by the potentially lower energy expenditure during a PRD which results from a reduced levodopa dosage and alleviated levodopa-related dyskinesia on the diet. In a case report published by Barichella et al a patient who used to experience a dramatic weight loss induced by dyskinesia, showed a satisfactory increase in body weight through a combination therapy of a protein-restricted diet and high-calorie oral supplements, demonstrating the positive effect of protein-restricted diets on weight gain in PD patients (Barichella et al, 2011). However, the report did not clarify which protein-restricted diet was used in this case.…”

Section: Clinical Effects Of Protein-restricted Dietsmentioning

confidence: 99%

Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease

Wang

Xiong

Huang

et al. 2017

Front. Aging Neurosci.

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Levodopa is considered to be the most effective symptomatic drug for Parkinson's disease (PD). As the disease progresses, however, the patients are likely to experience a reduced response to levodopa and develop motor fluctuations (i.e., end-of-dose wearing off and unpredictable “on-off”). Protein-rich diets and elevated plasma concentrations of large neutral amino acids have been proved to impair the therapeutic effect of levodopa by reducing its absorption and influx into the brain. On the other hand, the protein-restricted diets including low-protein diet (LPD), protein-redistribution diet (PRD) and PRD with use of low-protein products can all improve the efficacy of levodopa in patients with motor fluctuations. However, it should be noted that protein-restricted diets may also contribute to several side effects, including dyskinesia, weight loss, and malnutrition (e.g., protein and calcium insufficiency). Together, protein-restricted diets are an effective approach to improve motor fluctuations in PD patients, while long-term adherence to these diets requires monitoring for side effects.

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Section: Clinical Effects Of Protein-restricted Dietsmentioning

confidence: 99%

Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease

Wang

Xiong

Huang

et al. 2017

Front. Aging Neurosci.

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“…On the contrary, during the advanced stages of the disease, progressive body weight loss occurs, probably on account of the increase in energy expenditure produced mainly by muscle hypertonia and any dyskinesias [1,[3][4][5]. In some patients calorie-rich food supplements may be required to counteract body weight loss, meeting calorie requirements [6]. An indirect demonstration that dyskinesias have an important role to play in energy consumption is the body weight gain that occurs in patients who undergo deep brain stimulation (DBS), which reduces motor fluctuations [7].…”

Section: Introductionmentioning

confidence: 99%

Dietary habits and neurological features of Parkinson's disease patients: Implications for practice

Barichella¹,

Cereda²,

Cassani³

et al. 2017

Clinical Nutrition

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“…The use of a high‐protein, high‐energy (HPHE) diet in malnourished PWP may interfere with the levodopa in dopaminergic medication, and there is limited evidence to support an HPHE intervention . Despite this, an HPHE approach was used by the majority of the responding dietitians, perhaps indicating a higher priority for the management of malnutrition than on the potential benefit of limiting protein on medication effectiveness.…”

Section: Discussionmentioning

confidence: 99%

Current practice in nutrition diagnosis and intervention for the management of Parkinson's disease in Australia and Canada

Sheard

Ash

2014

Nutrition & Dietetics

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Aim To document current practice by dietitians in Australia and Canada in the nutrition management of Parkinson's disease. This will help identify priority areas for review and development of practice guidelines and direct future research. Methods Current practice in the phases of the Nutrition Care Plan was captured using an online survey distributed to Dietitians Association of Australia members and Practice‐Based Evidence in Nutrition subscribers through their email newsletters. The results of the diagnosis, intervention and monitoring phases are presented here. Results Eighty‐four dietitians responded. There was consistency in practice for nutrition issues that are encountered in other populations, such as malnutrition and constipation. There was more variation in practice in the nutrition issues that are more specific to Parkinson's disease, such as nutrition and meal interactions with medication. A lack of awareness of emerging treatments, such as deep brain stimulation surgery, appears to exist in the responding dietitians. Conclusions The variation in practice that was present for the nutrition issues specific to Parkinson's disease may reflect the lack of quality evidence and subsequently evidence‐based guidelines in these areas. Work to provide background information about treatment options and to translate current evidence for the nutrition issues that are specific to Parkinson's disease into practice recommendations should be completed.

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Oral high-calorie, low-protein supplements in a Parkinson's disease patient: A case report

Cited by 6 publications

References 7 publications

Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease

Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease

Dietary habits and neurological features of Parkinson's disease patients: Implications for practice

Current practice in nutrition diagnosis and intervention for the management of Parkinson's disease in Australia and Canada

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