Oral human papillomavirus (HPV) prevalence in youth and cervical HPV prevalence in women attending a youth clinic in Sweden, a follow up-study 2013–2014 after gradual introduction of public HPV vaccination

Grün, Nathalie; Ährlund‐Richter, Andreas; Franzén, Joar; Mirzaie, Leila; Marions, Lena; Ramqvist, Torbjörn; Dalianis, Tina

doi:10.3109/00365548.2014.964764

Cited by 33 publications

(31 citation statements)

References 16 publications

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“…In Japan, the decreasing average age at starting sexual activities may have increased the HPV infection rate in young people [48, 49]. The most common high-risk type of HPV infection seen in the oral cavity and cervix of sexually active young people is HPV16 [9, 12, 13, 27, 47]. Furthermore, HPV42 is a common low-risk HPV type seen in those locations in young females [9, 27], while HPV18 is commonly found in the cervix but not the oral cavity in young subjects [9, 12, 13, 27].…”

Section: Discussionmentioning

confidence: 99%

“…The most common high-risk type of HPV infection seen in the oral cavity and cervix of sexually active young people is HPV16 [9, 12, 13, 27, 47]. Furthermore, HPV42 is a common low-risk HPV type seen in those locations in young females [9, 27], while HPV18 is commonly found in the cervix but not the oral cavity in young subjects [9, 12, 13, 27]. Most HPV types commonly detected in the cervix are also found in the oral cavity, suggesting that concomitant HPV infection in those locations is common in young females [27, 50].…”

Section: Discussionmentioning

confidence: 99%

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Risk Factors for Oral Human Papillomavirus Infection in Healthy Individuals: A Systematic Review and Meta-Analysis

Shigeishi

Sugiyama

2016

J Clin Med Res

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BackgroundOral human papillomavirus (HPV) infection is associated with oral cancer development. However, few epidemiologic investigations have focused on oral HPV prevalence in healthy individuals. The objective of this study was to provide updated information regarding oral HPV prevalence in patients without oral cancer worldwide.MethodsWe systematically reviewed 29 studies reporting the prevalence of oral HPV infection that included 22,756 subjects (10,124 males, 12,623 females, and nine unknown gender; age range 2 - 89 years) and were published from January 2012 to June 2015.ResultsThe prevalence of overall HPV, low-risk type HPV, high-risk type HPV, and HPV16 in the reported cases was 5.5%, 2.2%, 2.7%, and 1.0%, respectively. The prevalence of overall HPV was considerably higher in males who had sex with males (12.2%) as compared to heterosexual males (4.7%) and females (2.9%). A meta-analysis was performed to elucidate significant risk factors for oral HPV infection, which revealed a significant statistical association for oral sex and smoking with oral HPV infection (odds ratio (OR): 1.90, 95% confidence interval (CI): 1.51 - 2.39, P < 0.0001; OR: 2.13, 95% CI: 1.32 - 3.43, P = 0.002).ConclusionsOur findings suggest that sexual behavior and smoking are importantly related to oral HPV infection in healthy individuals.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Risk Factors for Oral Human Papillomavirus Infection in Healthy Individuals: A Systematic Review and Meta-Analysis

Shigeishi

Sugiyama

2016

J Clin Med Res

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“…Some 17% of the female participants enrolled in our study had been vaccinated against HPV. The only studies [39,48,49] investigating the effect of HPV vaccination on oral HPV infection in females reported a lower prevalence of oral HPV infection in the vaccinated group. Here in this region of Italy, the most utilized HPV vaccine is the quadrivalent vaccine (Gardasil®) that provides protection against HPV types 6, 11, 16 and 18.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Determinants of Oral Human Papillomavirus Infection in 500 Young Adults from Italy

et al. 2017

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Although the prevalence of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) is increasing in developed countries and becoming a relevant health issue, the natural history of oral HPV infection is still unclear. Estimating the infection’s prevalence in specific populations and identifying risk factors can widen our understanding of its natural history and help to delineate appropriate prevention strategies. This study sought to (i) determine oral HPV prevalence and genotype distribution in a large series of young Italian adults, (ii) validate an oral rinse sampling/storage protocol, and (iii) pinpoint factors associated with oral HPV infection. Five hundred students, nurses, and technicians (19–35 years-old) studying and working at/for the University of Padua were recruited. Each participant was provided with an oral rinse sampling kit and instructions for use. They were also asked to complete an anonymous questionnaire concerning their demographic characteristics and behaviors. The questionnaires and oral rinse containers were labeled with the same identification code number. The oral rinse samples were tested using a bead-based multiplex BSGP5+/6+-MPG genotyping assay which amplifies the L1 region of 51 mucosal HPV types. The prevalence of oral HPV infection was 4.0% (95% confidence interval (CI), 2.5%-6.1%); those of 14 high-risk HPV types and of HPV-type 16 (HPV16) infection were 2.2% (95% CI, 1.1%-3.9%) and 1.6% (95% CI, 0.6%-3.1%), respectively. HPV16 was the most frequent genotype (40.0% of oral HPV infections). No association was found between oral infection and the co-variables studied (gender, tobacco, alcohol and illegal drug use, number of sex and oral sex partners, HPV vaccination status, history of HPV and sexually transmitted infections, abnormal pap smears, recurrent tonsillitis and tonsillectomy). The oral rinse sampling protocol outlined here proved to be simple, efficient and well tolerated, and the prevalence rate can be considered reliable and thus useful to guide future research. Determinants of oral HPV infection are still unclear and further studies are certainly warranted.

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“…Todays’ HPV vaccines Cevarix (GMK) and Gardasil (Merk) consist of VLPs from different HPV types and both contain HPV16 and 18 VLPs, while the latter also contains VLPs also of HPV6 and HPV11 [ 30 , 31 ]. These vaccines have been shown to be very efficient against cervical HPV infection, and also very likely efficient against oral HPV infection [ 30 , 31 , 32 , 33 , 34 , 35 ].…”

Section: Human Papillomavirus (Hpv) and Disease And Cancermentioning

confidence: 99%

Human Papillomavirus and Tonsillar and Base of Tongue Cancer

Ramqvist

Grün

Dalianis

2015

Viruses

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In 2007, human papillomavirus (HPV) type 16 was recognized as a risk factor by the International Agency for Research on Cancer, for oropharyngeal squamous cell carcinoma (OSCC), where tonsillar and base of tongue cancer (TSCC and BOTSCC) dominate. Furthermore, patients with HPV-positive TSCC and BOTSCC, had a much better clinical outcome than those with corresponding HPV-negative cancer and other head and neck cancer. More specifically, survival was around 80% for HPV-positive TSCC and BOTSCC vs. 40% five-year disease free survival, for the corresponding HPV-negative tumors with conventional radiotherapy and surgery, while this could not be observed for HPV-positive OSCC at other sites. In addition, the past 20–40 years in many Western Countries, the incidence of HPV-positive TSCC and BOTSCC has risen, and >70% are men. This has resulted in a relative increase of patients with HPV-positive TSCC and BOTSCC that may not need the intensified chemo-radiotherapy (with many more severe debilitating side effects) often given today to patients with head and neck cancer. However, before tapering therapy, one needs to enable selection of patients for such treatment, by identifying clinical and molecular markers that together with HPV-positive status will better predict patient prognosis and response to therapy. To conclude, there is a new increasing group of patients with HPV-positive TSCC and BOTSCC with good clinical outcome, where options for better-tailored therapy are needed. For prevention, it would be of benefit to vaccinate both girls and boys against HPV16 infection. For potential future screening the ways to do so need optimizing.

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Oral human papillomavirus (HPV) prevalence in youth and cervical HPV prevalence in women attending a youth clinic in Sweden, a follow up-study 2013–2014 after gradual introduction of public HPV vaccination

Cited by 33 publications

References 16 publications

Risk Factors for Oral Human Papillomavirus Infection in Healthy Individuals: A Systematic Review and Meta-Analysis

Risk Factors for Oral Human Papillomavirus Infection in Healthy Individuals: A Systematic Review and Meta-Analysis

Prevalence and Determinants of Oral Human Papillomavirus Infection in 500 Young Adults from Italy

Human Papillomavirus and Tonsillar and Base of Tongue Cancer

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