Oral Human Papillomavirus in Healthy Individuals: A Systematic Review of the Literature

Kreimer, Aimée R.; Bhatia, Rohini; Messeguer, Andrea L.; González, Paula; Herrero, Rolando; Giuliano, Anna R.

doi:10.1097/olq.0b013e3181c94a3b

Cited by 265 publications

(254 citation statements)

References 33 publications

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“…It has been previously reported that the HPV infection rate in the normal human oral area is 4.5 %, and that there is no difference between the infection rate of males and females 34) . Although the nature of the infection differed between healthy people and OLP patients, the HPV infection rate in the oral area does not appear to be associated with sex.…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus in Oral Lichen Planus of Japanese Patients

Kato

Kawai

Isomura

et al. 2015

J. Hard Tissue Biology.

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Oral lichen planus (OLP) can undergo malignant transformation and become squamous cell carcinoma (SCC). Oral infection with human papillomavirus (HPV) is associated with a significant risk of developing oral cancer. Although HPV DNA is detected more often in OLP tissue than in normal oral mucosa, there is as yet no firm evidence that HPV is a causative factor of malignant transformation in OLP. The objective of the present investigation was to assess HPV-genotype distribution in OLPs of Japanese patients and additionally to clarify the relationship between malignant transformation in OLP and HPV infection using PCR, in situ hybridization, and immunohistochemistry. DNA of 200 formalin-fixed, paraffin-embedded biopsy and surgical specimens of OLP was extracted. HPV infection was first detected by PCR using consensus HPV primers. Positive PCR samples were then further analyzed by PCR using HPV type-specific primers (HPV-6, -11, -16, -18 and -33). Eighty-three samples (41.5 %) out of the total 200 OLP specimens analyzed were HPV positive. In the HPV type-specific PCR assay, the most frequent type of HPV was HPV-16 (25.5 %), which is a high-risk type of HPV that is associated with malignant disorders and is often detected in SCC. The highest HPV-16 positive rate was obtained for the erosive type of OLP (28.3 %). Positive staining for HPV DNA by in situ hybridization was observed in the nuclei of cells in all layers of the epithelium in all HPV PCR positive samples. Immunohistochemically, nuclei of cells in the upper layer of the epithelium in all HPV PCR positive samples stained positive for the anti-HPV antibody. These results indicated that HPV-16 was often present in OLP of Japanese patients, especially in the erosive type of OLP, and suggested that HPV infection is a risk factor for malignant transformation in OLP lesions.

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Section: Discussionmentioning

confidence: 99%

Human Papillomavirus in Oral Lichen Planus of Japanese Patients

Kato

Kawai

Isomura

et al. 2015

J. Hard Tissue Biology.

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“…Gillison and colleagues reported an HPV prevalence of 10.1% for men and 3.7% for women in the general United States population; (12) the prevalence of HPV-16 was 1%. Overall HPV prevalence was associated with oral sex, number of lifetime sex partners, and current number of cigarettes smoked per day (10,(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

“…Recent increases in the incidence of HPV-positive oropharyngeal cancers in the United States and worldwide (2)(3)(4)(5)(6)(7)(8), particularly among young people who neither smoke nor drink have been attributed to changes in sexual behavior such as increased oral sex, which may expose individuals to oral HPV infection (1,3,4,9). The prevalence of HPV in healthy oral mucosa (10,11) ranges from 1.3% to 9.2%, with high-risk HPV-16 the most common type (10,12,13). Gillison and colleagues reported an HPV prevalence of 10.1% for men and 3.7% for women in the general United States population; (12) the prevalence of HPV-16 was 1%.…”

Section: Introductionmentioning

confidence: 99%

Examining the Association between Oral Health and Oral HPV Infection

Bui

Markham

Ross

et al. 2013

Cancer Prevention Research

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Oral human papillomavirus (HPV) infection is the cause of 40% to 80% of oropharyngeal cancers; yet, no published study has examined the role of oral health in oral HPV infection, either independently or in conjunction with other risk factors. This study examined the relation between oral health and oral HPV infection and the interactive effects of oral health, smoking, and oral sex on oral HPV infection. Our analyses comprised 3,439 participants ages 30 to 69 years for whom data on oral HPV and oral health were available from the nationally representative 2009-2010 National Health and Nutrition Examination Survey. Results showed that higher unadjusted prevalence of oral HPV infection was associated with four measures of oral health, including self-rated oral health as poor-to-fair [prevalence ratio (PR) ¼ 1.56; 95% confidence interval (CI), 1.25-1.95], indicated the possibility of gum disease (PR ¼ 1.51; 95% CI, 1.13-2.01), reported use of mouthwash to treat dental problems in the past week (PR ¼ 1.28; 95% CI, 1.07-1.52), and higher number of teeth lost (P trend ¼ 0.035). In multivariable logistic regression models, oral HPV infection had a statistically significant association with self-rated overall oral health (OR ¼ 1.55; 95% CI, 1.15-2.09), independent of smoking and oral sex. In conclusion, poor oral health was an independent risk factor of oral HPV infection, irrespective of smoking and oral sex practices. Public health interventions may aim to promote oral hygiene and oral health as an additional measure to prevent HPV-related oral cancers. Cancer Prev Res; 6(9); 917-24. Ó2013 AACR.

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“…In OSCC and OPSCC, the HR-HPV HPV-16 is considered to play an important role in malignant transformation 14,22) . Recent studies have found that the frequency of HPV-16 infection in OSCC ranges from 10.6 to 81.3 % using PCR 3,[23][24][25][26][27][28] .…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Type 16 Infection and Local Lymph Node Metastasis in Patients with Squamous Cell Carcinoma

Kawai

Isomura

Sato

et al. 2016

J. Hard Tissue Biology.

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Human papillomavirus (HPV) infection is known to be an independent etiologic factor for oral squamous cell carcinoma (OSCC). Especially, HPV-16 is associated with a significant risk of developing OSCC. The most important prognostic factor in OSCC is local lymph node metastasis (LNM); therefore, knowledge of LNM status is crucial for selecting proper treatment plans. However, it is not clarify relationship between HPV-16 infection and LNM in OSCC. The purpose of this study was to determine the role of HPV-16 infection in LNM in OSCC. We analyzed 130 cases of OSCC (100 cases of OSCC without LNM; 30 cases of OSCC with LNM). HPV-16 infection was detected by PCR, immunohistochemical examination and in situ hybridization. HPV-16 positivity rates among primary tumor (PT) specimens without LNM were 43.0 % (43/100), and HPV-16 positivity rates among PT specimens with LNM were 26.7 % (8/30). In addition, HPV-16 positivity rates in both PT and LNM specimens in 30 OSCC patients with LNM were 10 % (3/30). OSCC with HPV-16 DNA detected by PCR showed positive staining on immunohistochemical examination and in situ hybridization. The HPV-16 infection rate in OSCC with LNM was significantly lower than that for OSCC without LNM. In the case of OSCC with LNM, HPV-16 infection rates for both in PT and LNM were low. This suggests that HPV-16 positive cases had a significantly lower risk of LNM when compared with patients having HPV-16 negative OSCC. The results of the present study suggest that HPV status in OSCC is able to act as a marker for risk of LNM.

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Oral Human Papillomavirus in Healthy Individuals: A Systematic Review of the Literature

Cited by 265 publications

References 33 publications

Human Papillomavirus in Oral Lichen Planus of Japanese Patients

Human Papillomavirus in Oral Lichen Planus of Japanese Patients

Examining the Association between Oral Health and Oral HPV Infection

Human Papillomavirus Type 16 Infection and Local Lymph Node Metastasis in Patients with Squamous Cell Carcinoma

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