Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults

Riddell, James; Brouwer, Andrew F.; Walline, Heather M.; Campredon, Lora P; Meza, Rafael; Eisenberg, Marisa C.; Andrus, E. Cowles; Delinger, Rachel; Yost, Monica; McCloskey, Jodi K; THOMAS, T. TURNER; Huang, Suiyuan; Ferris, Robert L.; Shin, Dong M.; Fakhry, Carole; Ow, Thomas J.; Li, Daniel; Berlot, Ashley; Carey, Thomas E.

doi:10.1016/j.tvr.2022.200237

Cited by 13 publications

(16 citation statements)

References 48 publications

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“…[12][13] A recent case-control study evaluated the prevalence of oral HPV infection among 245 HIV + and 198 HIV-patients. [14] Overall, the HIV + population had a higher prevalence (23%) compared to the healthy individuals (10%), with the highest numbers found in young HIV + male patients (27%), patients with poorly controlled HIV (30%) and patients with a history of more than 6 lifetime partners (15.7%). People Living with HIV have a risk 2-3-fold higher of prevalent oral HPV infection and 2-6 fold-higher of OPC than HIV-uninfected individuals [15] , [16].…”

Section: Introductionmentioning

confidence: 93%

Detection of Human Papillomavirus infection in oral mucosal diseases: a single-center study

Fantozzi

Romeo

Tenore

et al. 2023

Preprint

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Background: Human papillomavirus (HPV) infection accounts for more than 70% of oropharyngeal cancers, but only a small proportion of oral potentially malignant disorders and oral squamous cell carcinoma. The aim of our study was to investigate the presence of HPV-DNA in oral diseases.Methods: This was a cross-sectional-study of 99 adult patients seen for the evaluation of oral diseases. All patients received an oral biopsy/histopathological examination and a brush biopsy for HPV-DNA detection/genotyping by real-time polymerase-chain-reaction. Immunohistochemistry was used to assess p16INK4a expression. P values were considered significant at P < 0.05.Results: HPV was identified in 15/99 (15.2%) patients (males:66.6%). Patients with oral lichen planus (OLP;23.8%), oral leukoplakia (OL;17.5%), and conditions of the buccal mucosa (BM;17.5%) had the highest rate of infection. Most patients with high-risk-HPV infection presented with OLP (19.1%), whereas most of the patients with low-risk-HPV infections had epithelial hyperkeratosis-non-reactive (9.4%). Amongst all benign lesions, 19.0% were positive for any HPV infection. One patient with OL showing mild-epithelial-dysplasia had a positive p16INK4a expression.Conclusions: The highest rate of HPV infection was in male patients, patients with OL/OLP, and in conditions of the BM. Larger studies are needed to elucidate the role of HPV in the development of these conditions.

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Section: Introductionmentioning

confidence: 93%

Detection of Human Papillomavirus infection in oral mucosal diseases: a single-center study

Fantozzi

Romeo

Tenore

et al. 2023

Preprint

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“…33 This finding is comparable to the age-related chronically higher incidence of HPV in HIV-negative individuals. 21 In a research study, it has been seen that the chance of contracting oral HPV, whether malignant or not, was comparable throughout ages, with the incidence of oral HPV, regardless of form, being maximum in men aged 31-50 within the initial 12 months of checkup. Also, after controlling for oral conditions, it was discovered that HIV-infected people had a two to three times greater risk of recurrent oral HPV transfection than HIV-uninfected people 17 (Figure 2).…”

Section: Epidemiology Of Oral Hpv Infection In the Setting Of Hiv Inf...mentioning

confidence: 99%

“…The incidence of oral HPV inflammation here seems to be significantly lesser when compared to any other HPV infestation in the overall inhabitants because people with HIV are more likely to evolve OSCC. 21 Oral HPV inflammation has additionally been noticed to be infrequently identified between HIVinfected persons, implying it may be dynamically operative or reactivated from a preceding dormant region. 22,23 In the age of potent combinations of antivirals, HPV-positive OSCC is also becoming a more serious source of illness and fatality for HIVinfected people.…”

Section: Epidemeologymentioning

confidence: 99%

A systematic review on the molecular and clinical association between Human Papillomavirus and Human Immunodeficiency Virus co‐infection in Head, Neck and Oral squamous cell carcinoma

Chakraborty

Ramasubbu

Banerjee

et al. 2023

Reviews in Medical Virology

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Head and neck cancer, one of the most commonly prevalent malignancies globally is a complex category of tumours that comprises cancers of the oral cavity, pharynx, and larynx. A specific subgroup of such cancers has been found with some unique chromosomal, therapeutic, and epidemiologic traits with the possibility of affecting via co‐infection. About 25% of all head and neck cancers in the population are human papillomavirus infection (HPV)‐associated, typically developing in the oropharynx, which comprises the tonsils. In the period of efficient combined antiviral treatment, HPV‐positive oral cancers are also becoming a significant contributor to illness and fatality for Human Immunodeficiency Virus (HIV)‐infected persons. Although the prevalence and historical background of oral HPV transmission are not thoroughly understood, it seems likely that oral HPV transmission is relatively frequent in HIV‐infected people when compared to the overall population. Therefore, there is a need to understand the mechanisms leading to this co‐infection, as there is very little research related to that. Hence, this study mainly focus on the therapeutical and biomedical analysis of HPV and HIV co‐infection in the above‐mentioned cancer, including oral squamous cell carcinoma.

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“…On average, HPV clearance is 6-12 months, regardless of HPV genotype. 124 When discussing sperm donation, the donors are usually men around 30-year-old, considered the highest Prevalence for HPV. Before the collection of sperm, many semen tests for semen pathogens are universally done in ART clinics, but HPV testing is often neglected.…”

Section: Future Perspectivementioning

confidence: 99%

“…Taking into account the global incidence of seminal HPV infection, potential partner transmission, and its effects on oncology and reproduction, it is very crucial to identify the clearance time for HPV infection in men. On average, HPV clearance is 6–12 months, regardless of HPV genotype 124 . When discussing sperm donation, the donors are usually men around 30‐year‐old, considered the highest Prevalence for HPV.…”

Section: Future Perspectivementioning

confidence: 99%

The impact of human papilloma virus on human reproductive health and the effect on male infertility: An updated review

Das

Fletcher

et al. 2023

Journal of Medical Virology

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It is believed that human papilloma virus infection (HPV), which is caused by the DNA virus, is the most prominent factor contributing to sexually transmitted disease (STD) in the world, with males having a prevalence rate of 3.5%-45% while that women are 2%-44%. Infertility is a rising problem on a global basis, affecting anywhere from 10% to 30% of couples who have reached reproductive age. This study aims to investigate the existing research on HPV, its connection to male infertility, and how it could be a helpful tool for medical professionals managing HPV in the context of reproductive health care. Infection with HPV has been identified as a risk factor for several spontaneous abortions; however, there is a lack of evidence on how HPV influences individuals undergoing assisted reproductive technology (ART) in terms of live births. The significance of the immune response to HPVinfected male reproductive system cells and its effect on embryos, as well as the oxidative stress generated by high-risk HPV DNA damage and genomic instability, is discussed in this review. Further, the association between male individuals infected with HPV and asthenozoospermia should provide a compelling case for vaccinating young people against HPV.

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Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults

Cited by 13 publications

References 48 publications

Detection of Human Papillomavirus infection in oral mucosal diseases: a single-center study

Detection of Human Papillomavirus infection in oral mucosal diseases: a single-center study

A systematic review on the molecular and clinical association between Human Papillomavirus and Human Immunodeficiency Virus co‐infection in Head, Neck and Oral squamous cell carcinoma

The impact of human papilloma virus on human reproductive health and the effect on male infertility: An updated review

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