Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period

Oe, Mariko; Sakai, Shizuyoshi; Yoshida, Hideto; Okado, Nao; Kaneda, Haruna; Masuda, Yasunobu; Urushibata, Osamu

doi:10.2147/ccid.s141845

Cited by 36 publications

(31 citation statements)

References 20 publications

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“…These findings are supported by other oral nutrition intervention studies where similar bioactive ingredients or sources were utilized, and similar results or the basis (the architecture) for the current results were found. [10][11][12]15,22,23 As the objective Canfield Visia-CR™ system was utilized for skin analysis, we also employed the subjective modified FACE-Q questionnaire as a means of capturing more robust information. The results on the subjective questionnaire in part support the objective improvements in overall skin appearance as observed with a reduction in crow's feet by week 4; however, the potential for placebo response cannot be discounted, as there were also aspects of the study that were not different between the groups.…”

Section: Con Clus Ionsmentioning

confidence: 99%

“…Subjects ingested 120 mg of HA per day. By week eight, those randomized to the HA group achieved significant improvements in skin wrinkles (such as crow's feet, etc) . This may be due in part to the “moisture” effect that hyaluronan has in human skin.…”

Section: Introductionmentioning

confidence: 99%

“…By week eight, those randomized to the HA group achieved significant improvements in skin wrinkles (such as crow's feet, etc). 11 This may be due in part to the "moisture" effect that hyaluronan has in human skin. In a recent publication, the authors stated that hyaluronan can increase skin moisture.…”

mentioning

confidence: 99%

“…In a recent publication, the authors stated that hyaluronan can increase skin moisture. 11 Keratan sulfate (KS) is also a natural GAG occurring in the hydrolyzed eggshell membrane. In the body, KS may influence wound healing, especially that of the skin.…”

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confidence: 99%

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The effect of oral hydrolyzed eggshell membrane on the appearance of hair, skin, and nails in healthy middle‐aged adults: A randomized double‐blind placebo‐controlled clinical trial

Hewlings

2020

J of Cosmetic Dermatology

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Background Many over the counter and consumer packaged goods are promoted to enhance the appearance of hair, skin, and nails for the consumer. Nutrition is a major factor in affecting the health and appearance of hair, skin, and nails. In addition to how one eats, dietary supplementation may play a role in overall health and in the physical appearance. Aims It was the aim of this study to objectively and subjectively evaluate the impacts of a nutritional intervention as compared to placebo on the appearances of hair, skin, and nails in healthy middle‐aged adults. Methods Randomized, double‐blind placebo‐controlled study with 88 subjects randomized evenly to Study Product (BiovaBio™ 450 mg/d, n = 44) or Placebo (n = 44) for 12‐weeks. Outcome tests included TrichoScan HD (hair), Canfield Visia®‐CR (skin), modified FACE‐Q (skin), and anchored Likert Scales (nails). Results Oral hydrolyzed eggshell membrane ingestion was associated with a significant improvement in facial skin appearance in crow's feet in 4 weeks and skin tone in 8 weeks, with significant impact on hair thickness, reduction in hair breakage and improvement in hair growth at 4, 8, and 12 weeks. There were no observed subjective improvements for nails (appearance, strength or growth). Conclusions Oral supplementation of 450 mg/d hydrolyzed eggshell membrane for 12 weeks is associated with improvement in the appearance of facial skin and hair.

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Section: Con Clus Ionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The effect of oral hydrolyzed eggshell membrane on the appearance of hair, skin, and nails in healthy middle‐aged adults: A randomized double‐blind placebo‐controlled clinical trial

Hewlings

2020

J of Cosmetic Dermatology

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“…After 12 weeks, the winkle parameters improved in both HA groups compared to the placebo. The 300 kDa HA worked somewhat faster (Oe et al, ).…”

Section: Oral Hamentioning

confidence: 99%

Aesthetic dermatology: What's new, what's true?

Wollina

Brzeziński

2018

Dermatologic Therapy

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Aesthetic dermatology (AD) is a rapidly growing subspecialty of dermatology. The acceptance of AD in scientific community and the society is associated with its competence, efficiency, and seriousness. This review highlights some recent developments toward new tools, techniques, and understanding in the field of AD. Analyzing the specific needs of patients and assessing the effect by objective measurements is important for further progress. For long time ignored, white adipose tissue has gained increasing interest in biology and rejuvenation. Characterization of dermal and subcutaneous white adipose tissue has made progress. The interaction of hyaluronic acid and calcium hydroxyl apatite (CaHA) fillers with adipocytes could be responsible for clinical efficacy. New developments of oral collagen treatment and highly diluted CaHA to contour the body outside the face will be discussed. Submental contouring using purified desoxycholic acid is another new development.

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Investigating the Skin Health Benefits of Rosa roxburghii, Punica granatum and Rose: A Randomized Single‐Blind Controlled Clinical Trial

Hao,

Wang,

2024

Food Science & Nutrition

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Recent studies underscore the beneficial impacts of oral natural plant extracts on human skin health, though clinical evidence of their efficacy and safety is limited. This study evaluates the skin health effects of a novel oral supplement containing Rosa roxburghii, Punica granatum, and rose extracts (RPR) 0.70 healthy female participants were randomly assigned to either a control group or an RPR group, with the latter ingesting 20 mL of the RPR supplement daily on an empty stomach over 8 weeks. After 8 weeks, the RPR group exhibited significant enhancements (p < 0.001) in skin hydration, glossiness, elasticity, and skin tone, with increases of 69.02%, 30.48%, 25.97%, and 7.52%, respectively. Concurrently, decreases in skin firmness and melanin levels were observed at 21.17% (p = 0.007) and 25.06% (p < 0.001), respectively. Statistical analysis confirmed that these changes were significantly greater than those in the control group. Image analysis indicated no significant changes in mean optical density of hyperpigmented spots within the RPR group (p = 0.367), but a significant reduction in the areas of hyperpigmented spots, under‐eye fine lines, and crow's feet by 41.50%, 37.55%, and 29.36%, respectively (p < 0.001), whereas no significant changes were detected in the control group. Importantly, no adverse effects were observed. These findings suggest that the combined intake of Rosa roxburghii, Punica granatum, and rose extracts can improve skin health, offering a promising natural alternative for dermatological care.

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Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period

Cited by 36 publications

References 20 publications

The effect of oral hydrolyzed eggshell membrane on the appearance of hair, skin, and nails in healthy middle‐aged adults: A randomized double‐blind placebo‐controlled clinical trial

The effect of oral hydrolyzed eggshell membrane on the appearance of hair, skin, and nails in healthy middle‐aged adults: A randomized double‐blind placebo‐controlled clinical trial

Aesthetic dermatology: What's new, what's true?

Investigating the Skin Health Benefits of Rosa roxburghii, Punica granatum and Rose: A Randomized Single‐Blind Controlled Clinical Trial

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