Oral hygiene, dentition, sexual habits and risk of oral cancer

Talamini, Renato; Vaccarella, Salvatore; Barbone, Fabio; Tavani, Alessandra; Vecchia, Carlo La; Herrero, Rolando; Muñóz, Núbia; Franceschi, Silvia

doi:10.1054/bjoc.2000.1398

Cited by 161 publications

(153 citation statements)

References 15 publications

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“…79 By contrast, several case-control studies observed no significant associations between risk of oral cancer and number of sex partners, frequency of oral sex, sex with prostitutes, or a history of genital herpes or gonorrhea. [92][93][94][95][96][97] Because only a fraction of oropharyngeal cancers are likely attributable to HPV, risk estimates may be attenuated if the majority of oral or oropharyngeal cancer cases are not etiologically associated with HPV. For example, case-control studies that observed no associations with sexual behaviors in the entire study population found that number of sexual partners, oral sex, and oral-anal contact were significantly associated with HPV-positive cases.…”

Section: Sexual Behavior and Human Papillomavirus Infectionmentioning

confidence: 99%

“…28,94,95,131,132 Clinical findings consistent with poor oral hygiene on examination (eg, mucosal irritation, dental caries, tartar) were associated with a 2-to 4-fold increase in risk after adjustment for sex, age, diet, alcohol, and tobacco habits. 93,133 The strongest and most consistent indicator of risk in the literature was tooth loss, likely indicative of chronic poor oral health. Several studies reported elevated risk associated with any tooth loss 90,93,129,[134][135][136] and also increased risk with increased number of lost teeth.…”

Section: Oral Hygienementioning

confidence: 99%

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Current topics in the epidemiology of oral cavity and oropharyngeal cancers

2007

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Oral cancer incidence rates rose dramatically during the twentieth century in the United States and Europe, especially among individuals under the age of 60 years. Although influenced by age, sex, and country of origin, incidence trends were most strongly affected by elevated risk among individuals born after approximately 1915. This cohort effect was indicative of strong behavioral influences on oral cancer risk. In this article, associations between oral cancer risk and established behavioral risk factors including alcohol and tobacco use are reviewed. Additionally, possible associations between oral cancer risk and oral hygiene, diet, nutritional status, and sexual behavior as well as the influence of genetic factors on oral cancer risk are considered. Special emphasis is placed on evaluating possible risk differences in individuals above and below the age of 45 and in users and nonusers of alcohol and tobacco. Oral squamous cell carcinomas arise from several anatomic sites within the oral cavity and oropharynx, but most commonly from the oral, mobile tongue.1 In the 1980s, 2 cancer centers in the United States (U.S.) reported an increase in the proportion of incident oral tongue cancers diagnosed in men younger 40 years.2,3 Although absolute numbers had increased, these reports provided no real evidence of rising incidence. Shortly thereafter, however, a significant 2-fold increase in oral tongue cancer mortality rates between 1950 and 1982 was reported in the U.S. for men younger than 30 years. 4 This finding was corroborated by a study in Scotland. 5 Further analysis of the Scottish data revealed that the increase in incidence was not restricted to those younger than 40 but extended to all age groups less than 65 years of age born after 1920-a strong ''cohort effect.'' The cohort effect was indicated by a strong effect of year of birth on oral cancer incidence rates. A flurry of research on global changes in oral cancer incidence was stimulated by these reports.

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Section: Sexual Behavior and Human Papillomavirus Infectionmentioning

confidence: 99%

Section: Oral Hygienementioning

confidence: 99%

Current topics in the epidemiology of oral cavity and oropharyngeal cancers

2007

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“…Recently, the role of other factors, such as poor oral hygiene and dentition (Talamini et al, 2000), genetic susceptibility (Warnakulasuriya et al, 1998), sexual habits (Garrote et al, 2001) and infection by human papillomavirus (Mork et al, 2001), has been investigated.…”

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confidence: 99%

Lifetime body mass index and risk of oral cavity and oropharyngeal cancer by smoking and drinking habits

et al. 2003

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The influence of body mass index (BMI) on oral cancer risk was evaluated in 375 incident cases and 375 age -gender-matched hospital-based controls. Low BMIs at diagnosis and 2 years before diagnosis were associated with significantly elevated odds ratios (OR for BMI p22 vs 426 kg m À2 ; 3.64; 95% confidence interval, CI: 2.27 -5.82 and 3.31; 95% CI: 2.04 -5.39, respectively). The association with low BMI, however, tended to be weaker and nonsignificant among never smokers and never drinkers. Pisani et al, 1999), most notably in young adults (Levi et al, 1999;Mackenzie et al, 2000;Llewellyn et al (2001)).Risk factors for oral cancer include tobacco smoking and alcohol consumption (Blot et al, 1988) and low intake of fruit and vegetables (Bosetti et al, 2000;Tavani et al, 2001). Recently, the role of other factors, such as poor oral hygiene and dentition (Talamini et al, 2000), genetic susceptibility (Warnakulasuriya et al, 1998), sexual habits (Garrote et al, 2001) and infection by human papillomavirus (Mork et al, 2001), has been investigated.The aim of this report is to assess whether body mass index (BMI) estimated at various points in life is related to oral cancer after taking into account the influence of established aetiological factors. MATERIAL AND METHODSThe present case -control study is part of an international study on oral cancer and human papillomavirus coordinated by the International Agency for Research on Cancer (IARC) (Herrero et al, in press) and carried out simultaneously in Spain, Italy, Ireland, Poland, Cuba, Canada, India, Sudan and Australia. The project was approved by the Ethical Committee of IARC and local research and ethical committees. Informed consent was obtained from each participant in the study.Eligible cases were incident, histologically confirmed and consecutively diagnosed (between 1996 and 1999) invasive cancers of the oral cavity and oropharynx, codes C 01 -C 10 of the second edition of the International Classification of Diseases for Oncology (Percy et al, 1990) from four hospitals: two in Barcelona, one in Granada and one in Seville. The overall participation among eligible cases was 76.5% (375 out of 490): 70.6% in Barcelona, 78.2% in Granada and 90.5% in Seville.Controls were in-patients or outpatients in the same hospitals with conditions unrelated to smoking, alcohol or long-term modification of diet. They were frequency-matched with cases by age (in 5-year periods), gender and hospital. One control was selected for each case in the 3-month time interval after the recruitment of the case. The overall participation among controls was 91% (375 out of 412): 91.1% in Barcelona, 91.2% in Granada and 90.5% in Seville. Exfoliated cells from oral cavity, blood samples and tissue biopsies were also collected from cases and controls.Identical questionnaires and coding manuals were used in each centre, and all interviewers received the same training and were routinely supervised. Body mass indexes were calculated from selfreported height and weight at diagnosis, 2 years befo...

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“…Lockhart et al (1998) did not find statistically significant results for association between oral cancer and dental factors, including tooth loss, defective teeth and denture use (Lockhart et al, 1998). Studies by Talamini and Rosenquist link dental status with oral cancer risk using control group randomly conformed (Talamini et al, 2000;Hansson et al, 2005).…”

Section: Discussionmentioning

confidence: 95%

Carcinoma of the Tongue: A Case-control Study on Etiologic Factors and Dental Trauma

Bektaş-Kayhan¹,

Karagöz²,

Kesimli³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Carcinoma of the tongue is the most common intra-oral malignancy in Western countries. Incidence and mortality rates have increased in recent years, and survival has not improved. This study aimed to determine etiologic factors for tongue cancer with age-sex matched case-control data. Materials and Methods: 47 patients with carcinoma of the tongue referred to our oral medicine clinic between years 2005-2006 were analyzed and compared with control group data. The medical records , including family history of cancer, dental trauma, and history of abuse of alcohol and tobacco products was recorded for all subjects. Chi square comparison tests and linear regression analysis were performed using the SPSS program for statistics. Results: Patient and randomly selected control groups each consisted of 30 male and 17 female subjects with mean ages 53.2 (±12.6) and 52.6 (±11.5) years respectively. Smoking and alcohol abuse proportions were significantly higher in the patient group (p=0.0001, p<0.0001 respectively). Chronic mechanical trauma was observed in 44.7% of the patients and 17.0% of the control group (p=0.004). Similarly, family history of cancer of any type (for the first degree relatives) was found to be more common in the patient group (p=0.009). On regression analysis, alcohol abuse, family history of cancer, smoking, chronic mechanical traumas appeared as significant etiologic factors (p=0.0001). Conclusions: We believe that field cancerization may become evident in oral and oropharyngeal mucosa with multiple steps of molecular changes starting from the first sign of dysplasia with chronic exposure to etiological factors. Chronic trauma cases need particular attention to search for very early signs of cancer.

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Oral hygiene, dentition, sexual habits and risk of oral cancer

Cited by 161 publications

References 15 publications

Current topics in the epidemiology of oral cavity and oropharyngeal cancers

Current topics in the epidemiology of oral cavity and oropharyngeal cancers

Lifetime body mass index and risk of oral cavity and oropharyngeal cancer by smoking and drinking habits

Carcinoma of the Tongue: A Case-control Study on Etiologic Factors and Dental Trauma

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