Oral <i>Astragalus</i>
 (Huang qi) for preventing frequent episodes of acute respiratory tract infection in children

Su, Guobin; Chen, Xiankun; Liu, Zhuangzhu; Yang, Lihong; La, Zhang; Lundborg, Cecilia Stålsby; Wen, Zehuai; Guo, Xinfeng; Qin, Xindong; Liang, Jueyao; Liu, Xusheng

doi:10.1002/14651858.cd011958.pub2

Cited by 14 publications

(6 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, YPFG contains astragalus (AR, Huangqi), the main active components of which are polysaccharides, saponins, and flavonoids, which can promote the maturation of acquired immune cells, enhance antibodies and improve innate immune function ( 56 ). Studies have confirmed astragalus, combined with other herbal treatments, can reduce the risk of acute respiratory infection (ARTIS) in children ( 57 ). The mechanism of YPFG regulating immune function is related to bile acid and glycerol phospholipid metabolism, and the active components of YPFG can affect this metabolism and inhibit inflammation ( 58 ).…”

Section: Discussionmentioning

confidence: 99%

Adjuvant treatment with yupingfeng granules for recurrent respiratory tract infections in children: A systematic review and meta-analysis

Zhang

Wang

et al. 2022

Front. Pediatr.

View full text Add to dashboard Cite

BackgroundYupingfeng granules (YPFG) contribute to various chronic respiratory infections. Several clinical studies have evaluated its efficacy and safety in treating recurrent respiratory tract infections (RRTIs) in children. However, the evidence for its use has not been conclusively proven.ObjectiveThe aim of this study was to demonstrate the efficacy and safety of YPFG in the adjuvant treatment of RRTIs in children.MethodsWe searched PubMed, Embase, Web of Science, Cochrane Library, Clinical Trials, Chinese Clinical Trial Registry, Sinomad, China National Knowledge Infrastructure (CNKI), Wanfang Database, and Chinese Scientific Journals Database (VIP) for randomized controlled trials (RCTs) of YPFG adjuvant therapy for children with RRTIs as of September 1, 2022. We screened the literature for inclusion and exclusion criteria, assessed the quality of each included literature, and then extracted data from each study for this systematic review and meta-analysis.ResultsA total of 17 RCTs were included. Data analysis showed that the total clinical response rate in the YPFG group was significantly higher than that in the control group [risk ratio (RR) = 1.18, 95%CI (1.12, 1.24), I2 = 39%, P < 0.00001]. Compared with the control group, three serum immunoglobulin levels were significantly increased in the YPFG group: IgA level [standardized mean difference (SMD) = 1.23, 95%CI (0.68, 1.78), I2 = 95%, P < 0.0001]; IgM level [SMD = 0.85, 95%CI (0.35, 1.35), I2 = 93%, P = 0.0009]; IgG level [SMD = 1.06, 95%CI (0.65, 1.47), I2 = 91%, P < 0.00001]. The TNF-α level was significantly lower in the YPFG group [SMD = −1.03, 95%CI (−1.55, −0.51), I2 = 84%, P = 0.0001] compared with the control group.ConclusionsIn summary, adjuvant YPFG therapy improves clinical efficacy and immunity in children with RRTIs. However, the effectiveness and safety of YPFG remain to be further verified.Systematic review registration[https://inplasy.com/inplasy-2022-3-0150/], identifier [INPLASY202230150].

show abstract

Section: Discussionmentioning

confidence: 99%

Adjuvant treatment with yupingfeng granules for recurrent respiratory tract infections in children: A systematic review and meta-analysis

Zhang

Wang

et al. 2022

Front. Pediatr.

View full text Add to dashboard Cite

show abstract

“…Chinese medicine practice over thousands of years has confirmed that A. membranaceus functions to replenish qi, which strengthens body resistance, promotes diuretic detoxification, heals sores, and prompts muscles. 9 – 12 It contains many chemical components, such as polysaccharides, saponins, flavonoids, amino acids, and certain trace elements. Our study found that Chahuangjing exhibits diuretic, tritium-removing, and free-radical-scavenging effects, which reduce internal HTO radiation injury.…”

Section: Discussionmentioning

confidence: 99%

Effects of Chahuangjing on Decorporation and Radiation Protection Against Tritiated Water

Zuo

Qiu

Houwen³

et al. 2018

Dose-Response

View full text Add to dashboard Cite

The purpose of this study was to investigate the effects of Chahuangjing, a novel traditional Chinese medicinal compound, on decorporation and radiation protection against tritiated water (HTO). Sixty male specific-pathogen-free-grade C57BL/6J mice were randomly divided into 12 groups: mice in 4 control groups were intraperitoneally injected with sterile water; mice in 4 HTO groups were intraperitoneally injected with 11.1 × 105 Bq/g of HTO; and mice in the other 4 groups were administered with HTO and a Chahuangjing compound (0.2 mL, once daily). After 1, 7, 14, and 21 days, the mice were killed and samples were collected. A liquid scintillation counting method was used for tritium measurement. A fully automated hematology analyzer was used to assess blood samples. The superoxide dismutase (SOD) and malondialdehyde (MDA) content was analyzed using commercial kits. Chahuangjing significantly increased decorporation and shortened the effective half-life of tritium. To a certain extent, Chahuangjing alleviated the HTO-induced reduction in white blood cells and elevated red blood cells after HTO exposure. Moreover, Chahuangjing alleviated the HTO-induced reduction in SOD activity and reduced MDA. Our study demonstrated that Chahuangjing can enhance the elimination of tritium and reduce free radicals to alleviate HTO-induced radiation injury.

show abstract

“…What is more, another study was conducted to assess the effectiveness and safety of oral AR for preventing frequent episodes of acute respiratory tract infections (ARTIs) in children. The results indicated that the intake of AR alone or in combination with other drugs can effectively enhance the immune function and prevent upper respiratory tract infection in children [171].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine

Guo

Lou

Kong

et al. 2019

IJMS

110

View full text Add to dashboard Cite

Astragali radix (AR) is one of the most widely used traditional Chinese herbal medicines. Modern pharmacological studies and clinical practices indicate that AR possesses various biological functions, including potent immunomodulation, antioxidant, anti-inflammation and antitumor activities. To date, more than 200 chemical constituents have been isolated and identified from AR. Among them, isoflavonoids, saponins and polysaccharides are the three main types of beneficial compounds responsible for its pharmacological activities and therapeutic efficacy. After ingestion of AR, the metabolism and biotransformation of the bioactive compounds were extensive in vivo. The isoflavonoids and saponins and their metabolites are the major type of constituents absorbed in plasma. The bioavailability barrier (BB), which is mainly composed of efflux transporters and conjugating enzymes, is expected to have a significant impact on the bioavailability of AR. This review summarizes studies on the phytochemistry, pharmacology and pharmacokinetics on AR. Additionally, the use of AR as a personalized medicine based on the BB is also discussed, which may provide beneficial information to achieve a better and more accurate therapeutic response of AR in clinical practice.

show abstract

Oral Astragalus (Huang qi) for preventing frequent episodes of acute respiratory tract infection in children

Abstract: We found insufficient evidence to enable assessment of the effectiveness and safety of oral Astragalus as a sole intervention to prevent frequent ARTIs in children aged up to 14 years.

Cited by 14 publications

References 46 publications

Adjuvant treatment with yupingfeng granules for recurrent respiratory tract infections in children: A systematic review and meta-analysis

Adjuvant treatment with yupingfeng granules for recurrent respiratory tract infections in children: A systematic review and meta-analysis

Effects of Chahuangjing on Decorporation and Radiation Protection Against Tritiated Water

A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine

Contact Info

Product

Resources

About