Oral Ibuprofen for Patent Ductus Arteriosus: Effective and Safe or Just Cheap?

Walther, Frans J.

doi:10.1159/000336712

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Except for GI toxicity, asthma is another adverse reaction associated with aspirin and ibuprofen [8,19]. These episodes of asthma tend to be life threatening, though unpredictable.…”

Section: Discussionmentioning

confidence: 99%

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Fisher Discrimination of Metabolic Changes in Rats Treated with Aspirin and Ibuprofen

Zhang

Song²,

Jiang³

et al. 2017

Pharmacology

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Background: Aspirin and ibuprofen are the most frequently prescribed non-steroidal anti-inflammatory drugs in the world. However, both are associated with a variety of toxicities. We applied serum metabonomics and Fisher discrimination for the early diagnosis of its toxic reaction in order to help diagnose these toxicities. Methods: A total of 45 rats were randomly divided into Control group, Aspirin group, and Ibuprofen groups. The experiment groups were given intragastric aspirin (15 mg/kg) or ibuprofen (15 mg/kg) for 3 weeks. Liver function tests were performed and blood metabonomics were analyzed by gas chromatography-mass spectrometry. Results: The most important compounds altered were trihydroxybutyric acid and l-alanine in the aspirin group, and acetoacetic acid, l-alanine, and trihydroxybutyric acid in the ibuprofen group. With respect to metabolic profiles, all 3 groups were completely distinct from one another. Fisher discrimination showed that 91.1% of the original grouped cases were correctly classified by the third week. However, only 55.6% of liver function tests were able to classify grouped cases correctly. Conclusion: Trihydroxybutyric acid, l-alanine, and acetoacetic acid were the most significant indicators of altered serum metabolites following intragastric administration of aspirin and ibuprofen in rates. These metabolomic data may be used for classification of aspirin and ibuprofen toxicity.

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“…Except for GI toxicity, asthma is another adverse reaction associated with aspirin and ibuprofen [8,19]. These episodes of asthma tend to be life threatening, though unpredictable.…”

Section: Discussionmentioning

confidence: 99%

“…Ibuprofen was derived from propionic acid and became available in the United Kingdom in 1969. It has been widely used in management of fever, pain, inflammatory diseases, migraines, and rheumatoid arthritis [8,9,10]. …”

Section: Introductionmentioning

confidence: 99%

Fisher Discrimination of Metabolic Changes in Rats Treated with Aspirin and Ibuprofen

Zhang

Song²,

Jiang³

et al. 2017

Pharmacology

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Comparison of Oral Versus Intravenous Nsaids for the Treatment of Patent Ductus Arteriosus in Preterm and/or Low Birth Weigh Infants: A Systematic Review and Meta-Analysis

Chaiyapak

2014

Value in Health

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A LT H 1 7 ( 2 0 1 4 ) A 7 1 9 -A 8 1 3 dementia (weighted sample= 16,272) took any antipsychotic medications; 69.7% were female and 68.8% were white. The average age was 85 years. Their physical functions were measured by the number activities of daily living (avg. 2.92) and number of instrumental activity of daily living (avg. 3.6). The most frequent diagnoses were Alzheimer's disease (78.8%) and vascular dementia (23.2%). I used the Neuropsychiatry Inventory (NPI) for behavior problems (delusions, hallucinations, agitation/aggression, depression, apathy, elation, anxiety, disinhibition, irritability/ lability, and aberrant motor behavior). I evaluated severity of dementia using the Clinical Dementia Rating Scale (CDR). I found that older persons with dementia are significantly more likely to relocate to the nursing home in 2 years if they were severely demented (OR= 1.3, p< .05), or were on antipsychotic medications (OR = 1.0 p< .05), or were getting older (OR= 0.01, p< .05). But, those who were living with caregiver (OR= -1.8, p< .01), or were Hispanic (OR= -1.4 p< .01) were significantly less likely to move to nursing homes. Alzheimer patients were significantly more likely to relocate to nursing home compared to vascular dementia patients (OR= -1.4, p< .05). ConClusions: Community-dwelling older persons with dementia are more likely to move to nursing home within 2 years if they had to be medicated for their behavior problems and were on antipsychotic medications and, the dementia is more advanced

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Oral Ibuprofen for Treatment of Patent Ductus Arteriosus: More than a Cheap Alternative

et al. 2012

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Oral Ibuprofen for Patent Ductus Arteriosus: Effective and Safe or Just Cheap?

Cited by 3 publications

References 26 publications

Fisher Discrimination of Metabolic Changes in Rats Treated with Aspirin and Ibuprofen

Fisher Discrimination of Metabolic Changes in Rats Treated with Aspirin and Ibuprofen

Comparison of Oral Versus Intravenous Nsaids for the Treatment of Patent Ductus Arteriosus in Preterm and/or Low Birth Weigh Infants: A Systematic Review and Meta-Analysis

Oral Ibuprofen for Treatment of Patent Ductus Arteriosus: More than a Cheap Alternative

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