Oral Imipramine and Acute Angle Closure Glaucoma

Ritch, Robert; Krupin, Theodore; Henry, Charles; Kurata, Fred

doi:10.1001/archopht.1994.01090130077021

Cited by 46 publications

(24 citation statements)

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“…Angle closure glaucoma precipitated by antianxiety agents and heterocyclic antidepressants has previously been reported [3, 4, 5]. To our knowledge, however, bilateral visual loss induced by these agents, as demonstrated in our patient, may be rare.…”

Section: Discussionsupporting

confidence: 49%

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Bilateral Angle Closure Glaucoma and Visual Loss Precipitated by Antidepressant and Antianxiety Agents in a Patient with Depression

et al. 2000

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A 71-year-old woman with depression had been treated with an antidepressant (maprotiline) and antianxiety agents (clotiazepam and alprazolam). She had previously complained of ocular pain and blurred vision. However, thorough ocular examination was not performed at those times. On examination, visual acuity was no light perception OD and hand motion OS. Intraocular pressures were 33 mm Hg OU. Moderately dilated pupils, atrophic irises, shallow anterior chambers and closed angles were seen in both eyes. Despite treatment, her visual acuity decreased to no light perception bilaterally. Psychiatrists and ophthalmologists should be aware that antidepressants and antianxiety agents can precipitate angle closure glaucoma in susceptible eyes.

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Section: Discussionsupporting

confidence: 49%

“…Antidepressants and antianxiety agents also dilate the pupil through an anticholinergic effect, resulting in angle closure glaucoma in predisposed individuals [1, 2, 3, 4, 5]. We have recently examined a patient with depression who had angle closure glaucoma and visual loss in both eyes.…”

Section: Introductionmentioning

confidence: 99%

Bilateral Angle Closure Glaucoma and Visual Loss Precipitated by Antidepressant and Antianxiety Agents in a Patient with Depression

et al. 2000

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“…56,57 The cause of ACAG in other groups of antidepressants is induced mydriasis by anticholinergic action of these medications in patients with narrow iridocorneal angle. Of tricyclic agents, amitryptiline (the most commonly reported agent) and imipramine 58 and of the non-tricyclic drugs, mianserin hydrochloride, 59 paroxetine, 57,60 fluoxetine, 61 maprotiline, 62,63 fluvoxamine, 64 venlafaxine, 65,66 citalopram, 67 and escitalopram 68 have been documented to be associated with ACAG attacks. Ritch et al 58 reported development of ACAG in four patients with occludable angles who received routinely prescribed doses of imipramine.…”

Section: Antidepressantsmentioning

confidence: 99%

Non-steroidal drug-induced glaucoma

Razeghinejad

Pro

Katz

2011

Eye

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Numerous systemically used drugs are involved in drug-induced glaucoma. Most reported cases of non-steroidal drug-induced glaucoma are closed-angle glaucoma (CAG). Indeed, many routinely used drugs that have sympathomimetic or parasympatholytic properties can cause pupillary block CAG in individuals with narrow iridocorneal angle. The resulting acute glaucoma occurs much more commonly unilaterally and only rarely bilaterally. CAG secondary to sulfa drugs is a bilateral non-pupillary block type and is due to forward movement of iris-lens diaphragm, which occurs in individuals with narrow or open iridocorneal angle. A few agents, including antineoplastics, may induce open-angle glaucoma. In conclusion, the majority of cases with glaucoma secondary to non-steroidal medications are of the pupillary block closed-angle type and preventable if the at-risk patients are recognized and treated prophylactically.

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“…This case is fundamentally related to these drugs' anticholinergic effect (mydriasis and cyclopegia). 28,30,31 In 1994, Ritch et al 30 have stated that in 4 narrow-angled patients, who were given oral imipramine in routine dose, acute angle closure triggered glaucoma attack . For this reason, TCAs should be carefully prescribed in narrow-angled patients and these patients should be kept under supervision by their ophthalmologist during the treatment.…”

Section: Antidepressants Tricyclic Antidepressant Agents (Tcas)mentioning

confidence: 99%

Psychotropic Drugs and Ocular Side Effects

Sönmez¹,

Aykan²

2013

Tjo

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Sum maryNowadays the number of patients using the types of drugs in question here has significantly increased. A study carried out in relation with the long term use of psychotropic drugs shows that the consumption of this group of drugs has substantially increased in terms of variety and quantity. This compilation is arranged in accordance with the ocular complications of psychotropic drugs in long term treatment profile of numerous patients to the results of related literature review. If the doctor and the patients are informed about the eye problems related to the use of psychotropic drugs, potential ocular complications can be easily prevented, supervised and controlled and can even be reversed. (

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Oral Imipramine and Acute Angle Closure Glaucoma

Cited by 46 publications

References 0 publications

Bilateral Angle Closure Glaucoma and Visual Loss Precipitated by Antidepressant and Antianxiety Agents in a Patient with Depression

Bilateral Angle Closure Glaucoma and Visual Loss Precipitated by Antidepressant and Antianxiety Agents in a Patient with Depression

Non-steroidal drug-induced glaucoma

Psychotropic Drugs and Ocular Side Effects

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