Oral immunotherapy for peanut allergy

Oral immunotherapy for food allergy: mechanisms and role in management

“…Although numerous studies of food OIT have been conducted to date, only a few adhered to a rigorous design, as recently critically reviewed by meta-analyses [30,31,53]. The meta-analyses highlighted tremendous heterogeneity in terms of the study design, inclusion criteria, dosing schedule, duration of therapy, and approach to evaluating the persistence of the protection following discontinuation of OIT.…”

“…Meta-analyses on immunotherapy for milk, egg, and peanut allergy pointed out significant limitations of the published studies [29][30][31]66]. Preliminary data suggest a beneficial treatment effect; however, there cannot be a definitive statement yet regarding efficacy, as no study has carried both a treatment and placebo arm to identical endpoints.…”

“…Following a long hiatus, the interest in the OIT ensued in the 1990s with a number of small, uncontrolled studies reported by European investigators, providing a proof of concept for larger controlled clinical trials [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. While multiple studies have been published to date, the interpretation of the results is affected by significant design heterogeneity that hampers the ability to directly compare the results [29][30][31].…”

Use of a Liver-Targeting Nanoparticle Platform to Intervene in Peanut-Induced Anaphylaxis Through Delivery of an Ara h2 T-Cell Epitope

“…Despite promising results from clinical trials that use oral or sublingual immunotherapy involving crude peanut protein extracts (CPPE), these interventions have many shortfalls [9][10][11][12]. Currently, there is only one FDA-approved oral immunotherapy treatment platform for peanut allergy, Palforzia, which is comprised of a powdered CPPE for oral desensitization therapy [13][14][15][16].…”

Allergen immunotherapy

“…monthly in a supervised medical setting with SCIT and at lowest three times a week with SLIT. Emerging evidence suggests that specific allergen immunotherapy may be effective in other allergic conditions such as IgE mediated food allergy [3,4] and extrinsic form IgE mediated Atopic Dermatitis [5]. On all these fields, the immunotherapy's triad can be an effective tool ( Figure 1).…”