Oral infection, hyperglycemia, and endothelial dysfunction

Janket, Sok‐Ja; Jones, Judith A.; Meurman, Jukka H.; Baird, Alison E.; Dyke, Thomas E. Van

doi:10.1016/j.tripleo.2007.06.027

Cited by 66 publications

(48 citation statements)

References 44 publications

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“…AGEs also function as a chemotactic for monocytes, thereby magnifying the inflammatory response, delaying wound healing and tissue repair and inducing connective‐tissue damage and bone resorption. Finally, hyperglycemia and the imbalance in lipid metabolism impair neutrophil and monocyte functioning 41‐44 . All of these factors may contribute to DM2 predisposing to periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Periodontitis Prevalence and Severity in Indonesians With Type 2 Diabetes

Susanto

Nesse

Dijkstra

et al. 2011

Journal of Periodontology

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Section: Discussionmentioning

confidence: 99%

Periodontitis Prevalence and Severity in Indonesians With Type 2 Diabetes

Susanto

Nesse

Dijkstra

et al. 2011

Journal of Periodontology

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“…The relationship of periodontal bone loss with abdominal obesity and other components of MetS, such as systolic blood pressure, is compatible with the hypothesis that local and systemic factors may contribute to a chronic inflammatory state, perhaps in a multiplicative manner, increasing the likelihood of developing MetS and cardiovascular disease. However, the extent to which other risk factors, such as type 2 diabetes, may underlie the mutual development of these conditions remains incompletely understood (25). …”

Section: Discussionmentioning

confidence: 99%

Association of periodontitis and metabolic syndrome in the Baltimore Longitudinal Study of Aging

et al. 2010

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Background and aims Metabolic syndrome (MetS) comprises central obesity, insulin resistance, hypertension and dyslipidemia, interrelated metabolic risk factors for diabetes and cardiovascular disease. A state of low-grade systemic inflammation may underlie this constellation of risk factors. Chronic inflammatory conditions, such as periodontal disease, may contribute to systemic inflammation and development of MetS. This study examines the association of periodontitis with MetS with and without consideration of systemic inflammatory status. Methods The association of alveolar bone loss (none/slight vs moderate/severe) determined from panoramic radiographs and MetS parameters were analyzed using logistic regression, adjusting for age, sex, ethnicity, and smoking in 112 men and 78 women (mean±SD age 56.7±13.3 and 60.0±12.1, respectively) participating in the Baltimore Longitudinal Study of Aging. Results Participants with radiographic evidence of moderate to advanced alveolar bone loss were significantly more likely to have MetS than those with minimal or no bone loss (OR 2.61, 95% CI 1.1–6.1, p<0.05). No significant differences in systemic inflammation were found between periodontal groups. Conclusions The association of alveolar bone loss to MetS is consistent with the hypothesis that destructive periodontal disease may contribute to the development of MetS and elevations in systemic inflammation. Longitudinal studies are necessary to clarify the role of periodontal disease in the development of MetS and conditions associated with chronic inflammation.

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“…However, extraction can affect subsequent nutritional intake (Nowjack‐Raymer & Sheiham , Janket et al . , Savoca et al . ) and the adverse effects of edentulism on health have been well substantiated (Brown ).…”

Section: Introductionmentioning

confidence: 99%