Oral ingestion of colostrum alters intestinal transforming growth factor-beta receptor intensity in newborn pigs

Mei, Jie; Zhang, Yuanqiang; Wang, Tian; Sangild, Per Torp; Ru, Xu

doi:10.1016/j.livsci.2006.06.017

Cited by 20 publications

(24 citation statements)

References 31 publications

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“…The latter may enhance TGF-␤ signaling and lead to receptor internalization in COLOS compared with IF pigs, as shown previously (26). Furthermore, we showed that distal intestinal levels of IL-8 were similar between healthy and NEC pigs in each diet and higher in IF vs. COLOS pigs.…”

Section: G694 Tgf-␤2 and Lps Regulate Intestinal Il-8 Levelssupporting

confidence: 88%

Transforming growth factor-β2 and endotoxin interact to regulate homeostasis via interleukin-8 levels in the immature intestine

Nguyen

Sangild

Østergaard

et al. 2014

American Journal of Physiology-Gastrointestinal and Liver Physi

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Section: G694 Tgf-␤2 and Lps Regulate Intestinal Il-8 Levelssupporting

confidence: 88%

Transforming growth factor-β2 and endotoxin interact to regulate homeostasis via interleukin-8 levels in the immature intestine

Nguyen

Sangild

Østergaard

et al. 2014

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Composition of sow colostrum Colostrum is regarded as the 'elixir of life' because of the high abundance of many different components (macronutrients and micronutrients and bioactive molecules such as immunoglobulins, growth factors and enzymes), and many of these components are important for survival of the newborn piglet and proper development of, for example, the gastrointestinal tract (Mei et al, 2006;Bjørnvad et al, 2007). Sow colostrum differs from mature milk in concentrations of macronutrients and immunoglobulins (Tables 1 and 2).…”

Section: Definitions Of Colostrum Transient Milk and Mature Sow Milkmentioning

confidence: 99%

Neonatal piglet survival: impact of sow nutrition around parturition on fetal glycogen deposition and production and composition of colostrum and transient milk

Theil

Lauridsen

Quesnel

2014

animal

183

161

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Piglet survival is a major problem, especially during the first 3 days after birth. Piglets are born deficient of energy, but at the same time they have a very high energy requirement because of high physical activity, high need for thermoregulation (because of their lean body with low insulation) and high heat production in muscle tissues. To be able to survive, newborn piglets may rely upon three different sources of energy, namely, glycogen, colostrum and transient milk, which orchestrate to cover their energy requirements. Piglets are born with limited amounts of energy in glycogen depots in the liver and muscle tissues and these depots are sufficient for normal activity for ∼16 h. Intake and oxidation of fat and lactose from colostrum must supply sufficient amount of energy to cover at least another 18 h until transient milk becomes available in the sow udder ∼34 h after the first piglet is born. Selection for large litters during the last two decades has challenged piglets even further during the critical neonatal phase because the selection programs indirectly decreased birth weight of piglets and because increased litter size has increased the competition between littermates. Different attempts have been made to increase the short-term survival of piglets, that is, survival until day 3 of lactation, by focusing on improving transfer of vital maternal energy to the offspring, either in utero or via mammary secretions. Thus, the present review addresses how sow nutrition in late gestation may favor survival of newborn piglets by increasing glycogen depots, improving colostrum yield or colostrum composition, or by increasing production of transient milk.

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“…For extremely premature infants, the early administration of colostrum helps compensate for the shortened period of in-utero amniotic fluid swallowing. Initial colostrum feedings stimulate rapid growth in the intestinal mucosal surface area, facilitate the endocytosis of protein, and induce many digestive enzymes 53, 58, 59. In animal models, the intestinal tract does not mature comparably if colostrum is not the first feeding 53, 58, 59.…”

Section: Critical Exposure Periods For the Use Of Human Milkmentioning

confidence: 99%

Improving the Use of Human Milk During and After the NICU Stay

Meier

Engstrom

Patel

et al. 2010

Clinics in Perinatology

164

167

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The feeding of human milk (milk from the infant's own mother; excluding donor milk) during the NICU stay reduces the risk of short-and long-term morbidities in premature infants, including: enteral feed intolerance; nosocomial infection; necrotizing enterocolitis (NEC); chronic lung disease (CLD); retinopathy of prematurity (ROP); developmental and neurocognitive delay; and rehospitalization after NICU discharge.1 -29 The mechanisms by which human milk provides this protection are varied and synergistic, and appear to change over the course of the NICU stay.30 , 31 In brief, these mechanisms include specific human milk components that are not present in the milk of other mammals, such the type and amount of long-chain polyunsaturated fatty acids and digestible proteins, and the extraordinary number of oligosaccharides (approximately 130). 32 Human milk also contains multiple lines of undifferentiated stem cells, with the potential to impact a variety of health outcomes through the lifespan.33 Other human milk mechanisms change over the course of lactation in a manner that complements the infant's nutritional and protective needs. These mechanisms include immunological, anti-infective, anti-inflammatory, epigenetic, and mucosal membrane protecting properties.34 -41 Thus, human milk from the infant's mother cannot be replaced by commercial infant or donor human milk, and the feeding of human milk should be a NICU priority.Recent evidence suggests that the impact of human milk on improving infant health outcomes and reducing the risk of prematurity-specific morbidities appears to be linked to specific critical exposure periods in the post-birth period during which the exclusive use of human milk and the avoidance of commercial formula may be most important. 29-31, 42, 43 Similarly, there are other periods when high doses, but not necessarily exclusive use of human milk, may be important. This chapter will review the concept of "dose and exposure period" for human milk feeding in the NICU to precisely measure and benchmark the amount and timing of human milk use in the NICU. Similarly, the critical exposure periods when exclusive or high doses of human milk appear to have the greatest impact on specific

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Oral ingestion of colostrum alters intestinal transforming growth factor-beta receptor intensity in newborn pigs

Cited by 20 publications

References 31 publications

Transforming growth factor-β2 and endotoxin interact to regulate homeostasis via interleukin-8 levels in the immature intestine

Transforming growth factor-β2 and endotoxin interact to regulate homeostasis via interleukin-8 levels in the immature intestine

Neonatal piglet survival: impact of sow nutrition around parturition on fetal glycogen deposition and production and composition of colostrum and transient milk

Improving the Use of Human Milk During and After the NICU Stay

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