Oral insulin delivery by self-assembled chitosan nanoparticles: In vitro and in vivo studies in diabetic animal model

Mukhopadhyay, Piyasi; Chakraborty, Mousumi; Bhattacharya, Sourav; Mishra, Roshnara; Kundu, Patit Paban

doi:10.1016/j.msec.2012.09.001

Cited by 166 publications

(97 citation statements)

References 40 publications

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“…Chitosan, high molecular weight as determined by Brookfield viscometer (800.00 cps in 1% w/w Chitosan aqueous 1% w/w acetic acid at 25°C), degree of deacetylation 87% (4) was kindly supplied by Aldrich Chemical Company (Germany). N, N-methylene bisacrylamide, ammonium persulfate were from Aldrich Chemical Company, Inc., Germany.…”

Section: Methodsmentioning

confidence: 99%

Antimicrobial and Haemostatic Effect of Chitosan/ Polyacrylic Acid Hybrid Membranes

Abdel‐Mohdy¹,

El-Bisi²,

Abou‐Okeil³

et al. 2016

Egypt. J. Chem.

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HITOSAN/ polyacrylic acid membranes containing different ……amounts of Al 2 (SO 4 ) and/or TiO 2 were prepared. The prepared membranes were characterized by measuring mechanical properties, such as tensile strength and elongation at break, swelling properties, antimicrobial and blood clotting. The results obtained indicate that the presence of Al 2 (SO 4 ) and TiO 2 in the membrane formulations has an incremental effect on the antimicrobial properties and blood clotting in albino rates.

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Section: Methodsmentioning

confidence: 99%

Antimicrobial and Haemostatic Effect of Chitosan/ Polyacrylic Acid Hybrid Membranes

Abdel‐Mohdy¹,

El-Bisi²,

Abou‐Okeil³

et al. 2016

Egypt. J. Chem.

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“…The primary building blocks of CS are glucosamine and N-acetyl-glucosamine. It is biocompatible, biodegradable and protective (Mukhopadhyay et al, 2013). The utilization of chitosan for oral insulin delivery is based on the mucoadhesive property and the ability to mediate the opening of the tight junctions reversibly (Jose et al, 2012(Jose et al, , 2013 (Figure 2).…”

Section: Natural Polymersmentioning

confidence: 99%

A review of biodegradable polymeric systems for oral insulin delivery

Luo

Xiong

Tian³

et al. 2015

Drug Delivery

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Currently, repeated routine subcutaneous injections of insulin are the standard treatment for insulin-dependent diabetic patients. However, patients' poor compliance for injections often fails to achieve the stable concentration of blood glucose. As a protein drug, the oral bioavailability of insulin is low due to many physiological reasons. Several carriers, such as macromolecules and liposomes have been used to deliver drugs in vivo. In this review article, the gastrointestinal barriers of oral insulin administration are described. Strategies for increasing the bioavailability of oral insulin, such absorption enhancers, enzyme inhibitors, enteric coatings are also introduced. The potential absorption mechanisms of insulin-loaded nanoparticles across the intestinal epithelium, including intestinal lymphatic route, transcellular route and paracellular route are discussed in this review. Natural polymers, such as chitosan and its derivates, alginate derivatives, g-PGA-based materials and starch-based nanoparticles have been exploited for oral insulin delivery; synthetic polymers, such as PLGA, PLA, PCL and PEA have also been developed for oral administration of insulin. This review focuses on recent advances in using biodegradable natural and synthetic polymers for oral insulin delivery along with their future prospects.

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“…Indeed, when the drug of interest must be used repeatedly and constantly, such as insulin, the oral route is considered the route of choice for patients. For this reason, insulin is foremost among the peptides that have gained much attention in terms of developing an oral form (Krishnankutty et al, 2009;Mukhopadhyay et al, 2013;Chaturvedi et al, 2013).…”

Section: Oral Route Of Protein Administrationmentioning

confidence: 99%