Oral insulin delivery – challenges and strategies

Sonia, Thundiparambil Azeez; Sharma, Chandra P.

doi:10.1533/9781908818683.113

Cited by 3 publications

(1 citation statement)

References 254 publications

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“…It was hypothesized that alteration of amino acid in F-box proteins might lead to diverse functions in fungi. It also reports that due to the amino acid substitution, the similar gene showed diverse function in insulin delivery and reduction of enzymatic activity in human [43,44].…”

Section: Discussionmentioning

confidence: 98%

Genome-wide identification of F-box proteins in Macrophomina phaseolina and comparison with other fungus

Sadat

Ullah

Bashar

et al. 2021

Journal of Genetic Engineering and Biotechnology

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Background In fungi, like other eukaryotes, protein turnover is an important cellular process for the controlling of various cellular functions. The ubiquitin-proteasome pathway degrades some selected intracellular proteins and F-box proteins are one of the important components controlling protein degradation. F-box proteins are well studied in different model plants however, their functions in the fungi are not clear yet. This study aimed to identify the genes involved in protein degradation for disease development in the Macrophomina phaseolina fungus. Results In this research, in silico studies were done to understand the distribution of F-box proteins in pathogenic fungi including Macrophomina phaseolina fungus. Genome-wide analysis indicates that M. phaseolina fungus contained thirty-one F-box proteins throughout its chromosomes. In addition, there are 17, 37, 16, and 21 F-box proteins have been identified from Puccinia graminis, Colletotrichum graminicola, Ustilago maydis, and Phytophthora infestans, respectively. Analyses revealed that selective fungal genomes contain several additional functional domains along with F-box domain. Sequence alignment showed the substitution of amino acid in several F-box proteins; however, gene duplication was not found among these proteins. Phylogenetic analysis revealed that F-box proteins having similar functional domain was highly diverse form each other showing the possibility of various function. Analysis also found that MPH_00568 and MPH_05531 were closely related to rice blast fungus F-box protein MGG_00768 and MGG_13065, respectively, may play an important role for blast disease development. Conclusion This genome-wide analysis of F-box proteins will be useful for characterization of candidate F-box proteins to understand the molecular mechanisms leading to disease development of M. phaseolina in the host plants.

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Section: Discussionmentioning

confidence: 98%

Genome-wide identification of F-box proteins in Macrophomina phaseolina and comparison with other fungus

Sadat

Ullah

Bashar

et al. 2021

Journal of Genetic Engineering and Biotechnology

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Role of lipid nanocarriers for enhancing oral absorption and bioavailability of insulin and GLP-1 receptor agonists

Poudwal

Misra

Shende

2021

Journal of Drug Targeting

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Enteric-Coated Polymers Past and Present - A Review

Loh¹,

Enose²,

Sangwan³

2022

DDL

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Tablet coating has evolved over the years and today, there are various types of coating for delayed release of a drug. Drugs can be enteric-coated to provide delayed release, protect the active pharmaceutical ingredients, minimize undesirable effects, and modify the pharmacokinetic properties of a drug, which will have clinical impacts. There are certain types of drugs that need to be enteric coated due to various reasons, such as it being a gastric irritant or it being acid liable. This article will review ethylcellulose and polymethacrylate, their role in an enteric coating, and their process coating parameters. Ethylcellulose can be used to provide a short delayed release; it can be modified by adding pH-dependent polymers such as sodium alginate and hydroxypropyl methylcellulose phthalate for a long delayed release. On the other hand, polymethacrylate can also be employed to enteric coat drugs without additional polymers. Polymethacrylate such as Eudragit comes in different grades with varying proportions of polymer ratio, allowing for targeted delayed drug release. These will impact which polymer to be employed. Upon choosing the coating material of choice, modeling can also be employed to predict in vitro and in vivo correlation as enteric-coated products can have unpredictable in vivo PK profiles. Today, the trend is moving away from the traditional coating and towards new polymers, and with digitalization, there is a focus to start using data from laboratory experiments to be integrated with computational modeling, artificial intelligence, and machine learning to accurately predict key process parameters and film properties for high-quality products.

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Oral insulin delivery – challenges and strategies

Cited by 3 publications

References 254 publications

Genome-wide identification of F-box proteins in Macrophomina phaseolina and comparison with other fungus

Genome-wide identification of F-box proteins in Macrophomina phaseolina and comparison with other fungus

Role of lipid nanocarriers for enhancing oral absorption and bioavailability of insulin and GLP-1 receptor agonists

Enteric-Coated Polymers Past and Present - A Review

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