Oral Iron Therapy-Induced Neutropenia in Patient with Iron Deficiency Anemia

Kloub, Mohammad N; Yassin, Mohamed A

doi:10.1159/000507730

Cited by 4 publications

(5 citation statements)

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“…(13) Another case report described the occurrence of neutropenia in a man after oral iron therapy that was transient and improved 1 month after stopping the iron tablets. (14) In our study the incidence of leukopenia, neutropenia and lymphopenia were with parental iron therapy was 1.9, 0.95, 0.76 percent, respectively in a large cohort of females treated with intravenous iron for IDA.…”

Section: Discussionsupporting

confidence: 45%

Iron Therapy-Induced Leukopenia in Arab Female Population, an experience in Qatar

Almasri¹,

Soliman²,

Desanctis³

et al. 2021

Preprint

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IntroductionIron deficiency anemia (IDA) is the most common cause of anemia in both developed and developing countries. Leukopenia is an infrequent side effect of iron therapy reported in the literature as sporadic cases. We conducted a study to clarify this issue and to check its consequences in a big cohort of patients with IDA.ObjectiveTo assess the relationship between iron therapy (intravenous) and leukopenia, neutropenia or lymphocytopenia, and its clinical impact, if any, on patients.Materials and Methodsthis is a retrospective study conducted in Hamad Medical Corporation, Doha/Qatar. the clinical and biochemical data of 1567 females with IDA who attended the hematology clinic and were treated with intravenous iron therapy were collected and analysed. Complete and differential blood counts and iron profile were studied before and after iron treatment. In addition, cases who developed infections during the time of leukopenia were noted and checked for possible complications.ResultsAfter iron therapy, out of 1567 case of iron deficiency anemia, 30 cases (1.914%) developed leukopenia,15 cases (0.957%) developed neutropenia and 12 cases (0.765%) developed lymphocytopenia. All had normal WBC counts before treatment. 2 patients (6.66%) had infection, 1 had upper respiratory tract infection and 1 urinary tract infection, the latter was treated with antibiotics. There were no reported infections during or after iron therapy.ConclusionsLeukopenia in form of neutropenia or lymphocytopenia may occur as a side effect of IV iron therapy, however, its clinical significance appeared to be limited.

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Section: Discussionsupporting

confidence: 45%

Iron Therapy-Induced Leukopenia in Arab Female Population, an experience in Qatar

Almasri¹,

Soliman²,

Desanctis³

et al. 2021

Preprint

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“…Iron status is considered as a variety of conditions ranging from iron deficiency (ID) with anaemia [i.e., reduced haemoglobin (Hb) in red blood cells—RBCs], to ID without anaemia (i.e., depleted iron stores), to normal iron status with varying amounts of stored iron, to iron overload [ 1 – 4 ]. Iron deficiency is a condition in which there are no mobilizable iron stores and in which signs of a compromised supply of iron to the tissues, including the erythron, are noted [ 4 , 5 ]. Globally, ID, specifically iron deficiency anaemia (IDA), remains one of the most public health nutritional problems [ 6 , 7 ] and constitutes a wide range of poor health outcomes [ 6 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…iron status with varying amounts of stored iron, to iron overload [1][2][3][4]. Iron deficiency is a condition in which there are no mobilizable iron stores and in which signs of a compromised supply of iron to the tissues, including the erythron, are noted [4,5]. Globally, ID, specifically iron deficiency anaemia (IDA), remains one of the most public health nutritional problems [6,7] and constitutes a wide range of poor health outcomes [6,8].…”

mentioning

confidence: 99%

Implication of asymptomatic and clinical Plasmodium falciparum infections on biomarkers of iron status among school-aged children in Malawi

Ntenda

Chirambo

Nkoka

et al. 2022

Malar J

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Background Iron status is considered as a continuum from an iron deficiency with anaemia, without anaemia, varying amounts of stored iron to iron overload. The burden of Plasmodium falciparum infections is typically high among school-aged children (SAC). Nonetheless, SAC are often less likely to be covered by malaria interventions, making them a group with an untreated reservoir of parasite transmission. This study aimed to assess the effects of asymptomatic and clinical malaria infections on biochemical markers of iron status among SAC in Malawi. Methods Data from the 2015–2016 Malawi Micronutrient Survey (MNS) was used and multivariable logistic regression models using a generalized estimating equation to account for the complex cluster survey design were constructed. Blood samples of 684 children aged 5 to 14 years old were evaluated for clinical and asymptomatic malaria infections. Furthermore, blood samples were used to estimate haemoglobin (Hb), serum ferritin (SF) and, soluble transferrin receptors (sTfR) concentrations. Results Of the 684 SAC analysed, approximately 42% had asymptomatic malaria, while 41.0% had clinical malaria. Anaemia (low Hb levels), iron deficiency (low SF concentration), and functional iron deficiency (high sTfR levels) were found in 20%, 5%, and 30% of the children, respectively. School-aged children with asymptomatic malaria had increased odds of being anaemic (adjusted odds ratio [aOR]: 3.71, 95% confidence interval [CI]: 2.29–5.99) and increased levels of sTfR (aOR: 3.00, 95% CI 2.01–4.47). Similarly, SAC with clinical malaria had increased odds of being anaemic (aOR: 3.54, 95% CI 2.19–5.72) and increased levels of sTfR (aOR: 3.02, 95% CI 2.02–4.52). Conclusions Both asymptomatic and clinical malaria were independent risk factors for anaemia and functional iron deficiency (FID). The notion that asymptomatic and clinical malaria were associated with both anaemia and FID underscores the need for public health programmers to consider adding mass screening and treatment for malaria to existing school-based health programmes.

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“…9 Rarely, with the correction of IDA, some patients develop transient neutropenia. 10 Anemia and thrombocytopenia can be seen together in various diseases; some of these diseases need urgent intervention, such as thrombotic microangiopathy and bone marrow replacement disorders, for example, leukemia; others are cold cases such as paroxysmal nocturnal hemoglobinuria, Evan's syndrome, and aplastic anemia, so it is always challenging to narrow the differential diagnosis early upon patient presentation as early intervention in some of this diseases has mortality benefit like in the case of thrombotic microangiopathy and leukemia. Blood peripheral smear is always the first step that usually can guide the management plan.…”

Section: Introductionmentioning

confidence: 99%

“…In rare conditions, IDA can be associated with thrombocytopenia, and there if IDA corrected the thrombocytopenia correct concurrently 9 . Rarely, with the correction of IDA, some patients develop transient neutropenia 10 …”

Section: Introductionmentioning

confidence: 99%