Oral Isotretinoin and Its Uses in Dermatology: A Review

Paichitrojjana, Anon; Paichitrojjana, Anand

doi:10.2147/dddt.s427530

Cited by 15 publications

(9 citation statements)

References 152 publications

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“…Isotretinoin is known for its diverse effects on severe acne and is also involved in decreasing the presence of P. acnes via changing the skin's microenvironment. However, the complete efficacy of isotretinoin is sometimes restricted by its inadequate solubility and bioavailability ( Paichitrojjana and Paichitrojjana, 2023 ). Improving these pharmacokinetic features using a self-nanoemulsifying drug delivery system (SNEDDS) could potentially enhance the inhibitory effect on P. acnes , resulting in a more effective acne treatment regimen ( Hosny et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Isotretinoin self-nano-emulsifying drug delivery system: Preparation, optimization and antibacterial evaluation

Alfaraj,

Hababah,

Eltayb

et al. 2024

Saudi Pharmaceutical Journal

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Section: Discussionmentioning

confidence: 99%

Isotretinoin self-nano-emulsifying drug delivery system: Preparation, optimization and antibacterial evaluation

Alfaraj,

Hababah,

Eltayb

et al. 2024

Saudi Pharmaceutical Journal

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“…Системные ретиноиды обладают противовоспалительным, антифибротическим, антиангиогенным и антиоксидантным действием. Изотретиноин снижает экспрессию патоген-ассоциированных Toll-подобных рецепторов 2-го типа, что способствует подавлению воспаления и уменьшает приток крови к лицу [10,[16][17][18]. Он способствует уменьшению размеров сальных желез, регулирует пролиферацию себоцитов, подавляет выработку кожного сала, изменяет микробиом кожи и снижает число Demodex spp.…”

Section: системная терапияunclassified

“…Он способствует уменьшению размеров сальных желез, регулирует пролиферацию себоцитов, подавляет выработку кожного сала, изменяет микробиом кожи и снижает число Demodex spp. [17].…”

Section: системная терапияunclassified

“…В ряде исследований сообщается о высокой частоте рецидивов розацеа (45-58,3%) в течение 11 мес. после терапии изотретиноином [17,24]. Возможно для предотвращения рецидива розацеа необходим длительный поддерживаю щий курс лечения, поэтому желательным является назначение наименьшей эффективной дозы [21].…”

Section: Dermal Diseasesunclassified

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Methods of rosacea treatment to achieve stable remission in a megalopolis

Vilochkina,

Lindover,

Galukhina

et al. 2024

Medicinskij sovet

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The review article is devoted to the aspects of rosacea therapy in a megalopolis, where a dermatological service is widely developed and it is possible to provide modern diagnostic, therapeutic and preventive measures. Rosacea negatively affects the emotional state of patients, and low awareness of chronic dermatoses often leads to self-medication and skin deterioration. The pathogenetic mechanisms of the disease have not been fully studied. Both genetic predisposition and environmental factors contribute to the occurrence of rosacea. A number of studies confirm that the triggers can be ultraviolet radiation, stress, intense physical activity, temperature changes, dietary characteristics, imbalance of the intestinal microbiota, alcohol consumption. Every day, residents of megalopolises face a combination of these factors, which combined with genetically determined features of the epidermal barrier and immune function, makes them more susceptible to rosacea and other skin diseases. The multifactorial nature of rosacea causes a variety of treatment methods that must be individualized in accordance with the clinical picture of the disease. With mild to moderate rosacea, monotherapy with external drugs is effective – azelaic acid, brimonidine tartrate, ivermectin, metronidazole. For the treatment of severe forms of rosacea, it is advisable to prescribe systemic therapy from groups of retinoids and antibiotics. The results of numerous studies are presented that physiotherapy methods which are available in large cities increase the effectiveness of treatment by reducing erythema and telangiectasia, enhancing repair and microcirculation in the epidermis. The accumulated experience of Russian dermatologists and foreign colleagues allows to determine the most effective combinations of treatment methods to achieve stable remission in patients.

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“…Характерно, що виникає клітинноопосередкована запальна відповідь, в якій переважають макрофаги та Т-хелпери (Th)-1 і Th-17 [13,14].…”

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Traditional and Alternative Methods of Acne Treatment

Bezeha,

Yemchenko,

Vasylyeva

et al. 2024

Act. Probl. of the Modern Med.

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Acne, characterized by chronic inflammation of the skin, has a multifactorial pathogenesis. Despite the array of available treatments, it remains one of the most prevalent dermatological conditions globally. While primarily affecting adolescents, a noteworthy and escalating number of cases occur in adults, particularly women. The complex pathogenesis of acne encompasses follicular hyperkeratinization, colonization by Cutibacterium acnes, sebum production, intricate inflammatory processes involving innate and acquired immunity, neuroendocrine mechanisms, and genetic and non-genetic factors. Risk factors include adolescence, familial predisposition, and oily skin. Although numerous acne treatments exist, ongoing efforts aim to mitigate side effects such as skin irritation, dryness, and photosensitivity, while enhancing efficacy through refined formulations and novel drugs with innovative mechanisms of action. Emerging products target various aspects of acne's multifactorial pathogenesis, offering promising advancements in treatment options. With the escalating concern over antibiotic resistance, current guidelines advocate for the judicious use of oral antibiotics and emphasize exploring alternative treatments. Isotretinoin stands out as a highly efficacious therapy for acne: it operates by reducing sebaceous gland size, decreasing sebum secretion, regulating cell proliferation and keratinization, while also possessing anti-inflammatory and immunomodulatory properties. Spironolactone also plays an important role in acne treatment; functioning as a synthetic aldosterone receptor antagonist with anti-androgenic attributes. Androgens exert significant physiological effects on the skin, regulating processes such as skin renewal, hair follicle growth, sebaceous gland proliferation, sebum production, and embryogenesis. Topical therapies serve as viable options for both initial treatment and maintenance of acne. They can be utilized as monotherapy (excluding topical antibiotics) or in combination with other topical or oral products.

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Oral Isotretinoin and Its Uses in Dermatology: A Review

Cited by 15 publications

References 152 publications

Isotretinoin self-nano-emulsifying drug delivery system: Preparation, optimization and antibacterial evaluation

Isotretinoin self-nano-emulsifying drug delivery system: Preparation, optimization and antibacterial evaluation

Methods of rosacea treatment to achieve stable remission in a megalopolis

Traditional and Alternative Methods of Acne Treatment

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