Oral language in children with benign childhood epilepsy with centrotemporal spikes

Teixeira, Joana; Santos, Miguel; Oom, Paulo

doi:10.1016/j.yebeh.2020.107328

Cited by 6 publications

(1 citation statement)

References 34 publications

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“…The most common language disabilities in children with CECTS are language comprehension and word generation 30 . It has been suggested that language disabilities appear early in the onset of CECTS and that longer duration of epilepsy is more likely to impair language function 31,32 . Persistent IED‐related functional alterations in perisylvian areas might be the underlying cause of language disabilities in this population.…”

Section: Discussionmentioning

confidence: 99%

Involvement of brain structures in childhood epilepsy with centrotemporal spikes

Ito

Maki

Okai

et al. 2022

Pediatrics International

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Background We aimed to investigate electroencephalography (EEG)‐functional magnetic resonance imaging (fMRI) findings to elucidate the interictal epileptiform discharge (IED)‐related functional alterations in deep brain structures and the neocortex in childhood epilepsy with centrotemporal spikes (CECTS). Methods Ten children with CECTS (median age 8.2 years), referred to our hospital within a year of onset, were eligible for inclusion. They underwent EEG‐fMRI recording during sleep. Llongitudinal evaluations, including medical examinations, intelligence tests, and questionnaires about developmental disabilities, were performed. The initial evaluation was performed at the same time as the EEG‐fMRI, and the second evaluation was performed over 2 years after the initial evaluation. Results Three children were unable to maintain sleep during the EEG‐fMRI recording, and the remaining seven children were eligible for further assessment. All patients showed unilateral‐dominant centrotemporal spikes during scans. One patient had only positive hemodynamic responses, while the others had both positive and negative hemodynamic responses. All patients showed IED‐related hemodynamic responses in the bilateral neocortex. For deep brain structures, IED‐related hemodynamic responses were observed in the cingulate gyrus (n = 4), basal ganglia (n = 3), thalamus (n = 2), and default mode network (n = 1). Seizure frequencies at the second evaluation were infrequent or absent, and the longitudinal results of intelligence tests and questionnaires were within normal ranges. Conclusions We demonstrated that IEDs affect broad brain areas, including deep brain structures such as the cingulate gyrus, basal ganglia, and thalamus. Deep brain structures may play an important role in the pathophysiology of CECTS.

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Section: Discussionmentioning

confidence: 99%