Oral Lead Exposure Induces Dysbacteriosis in Rats

Sadykov, R.; Digel, Ilya; Artmann, A.; Porst, Dariusz; Linder, Peter; Kayser, Peter; Artmann, G.M.; Savitskaya, Irina; Жубанова, А. А.

doi:10.1539/joh.m8009

Cited by 18 publications

(18 citation statements)

References 37 publications

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“…2 and Table S1 online). Consistent with our results, previous studies revealed that Pb and Cd exposure at environmentally-relevant low doses could alter the abundance of certain bacterial strains in the gut of mice, but may not induce significant effects on the global microbial diversity [16,17,19]. It is also noteworthy that very few studies can confirm the relationship between Al exposure and the gut microbiota.…”

Section: Discussionsupporting

confidence: 92%

“…In mice, exposure to Cd has been reported to induce sharp decreases in the populations of representative intestinal microbial species and a reduction in the abundance of total intestinal bacteria [16,17]. High levels of dietary Pb and Cu exposure were also found to induce gut microbiota dysbiosis in rats, piglets and humans [18][19][20]. Furthermore, the gut microbiota likely plays an important role in regulating the bioavailability and toxicity of these metals.…”

Section: Introductionmentioning

confidence: 99%

“…To the best of our knowledge, the effects of toxic metal exposure on the gut microbiota are not currently well understood. Several related studies have used culture-based and polymerase chain reaction (PCR)-denaturing gradient gel electrophoresis technologies to evaluate the effects of Cd, Pb and Cu on the gut microbiota of animals [16][17][18][19]. However, these investigations could have been improved by microbiome analyses based on Illumina highthroughput platforms, which provide more extensive and detailed information about the structure and diversity of the gut microbiota [22].…”

Section: Introductionmentioning

confidence: 99%

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Effects of subchronic oral toxic metal exposure on the intestinal microbiota of mice

Zhai

et al. 2017

Science Bulletin

107

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of subchronic oral toxic metal exposure on the intestinal microbiota of mice

Zhai

et al. 2017

Science Bulletin

107

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“…The analyses were conducted for 15 days, every day starting from a day of antibiotic treatment. Finally, the amount of Lactobacillus cells attached to the rat intestinal epithelium was directly counted as described elsewhere [48].…”

Section: Biological Objectsmentioning

confidence: 99%

Heterogeneous Composites on the Basis of Microbial Cells and Nanostructured Carbonized Sorbents

Mansurov¹,

Digel²,

Бийсенбаев³

et al. 2012

Composites and Their Applications

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“…The human gastrointestinal tract contains about 400 - 500 species of both aerobic and anaerobic microbes, such as Escherichia, Bacteroides, Bifidobacterium , and Lactobacillus genera 15 , 16) . Among normal intestinal flora, lactobacilli, E. coli , and Bacteroids play a major role in synthesizing the vitamins that are essential for human nutrition, and thus have a health promoting effect.…”

Section: Introductionmentioning

confidence: 99%

The effect of lead (Pb) exposure and iron (Fe) deficiency on intestinal lactobacilli, E. coli and yeast: A study in experimental rats

Reddy

Srivalliputturu

Bharatraj

2018

Journal of Occupational Health

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Objective: The current study investigated the additive effect of oral lead (Pb) exposure and dietary iron (Fe) deficiency on intestinal lactobacilli, E. coli, and yeast in SD rats. Methods: Weanling rats were fed on control diet (CD) or iron deficient diet (ID) for 4 weeks, followed by oral Pb exposure for another 4 weeks. Lead exposure was withdrawn for 2 weeks, and then resumed after 2 weeks. Blood samples were collected to determine haemoglobin (Hb), serum iron, blood Pb and δ-Aminolevulenic acid dehydratase (ALAD) activity. Fecal samples were collected to enumerate the lactobacilli, E. coli and yeast population on selective agar media and determine Pb levels. Results: Hb and serum Fe levels decreased significantly in iron deficient rats. Pb exposed rats had a significant increase in blood Pb levels and decreased ALAD activity. The lactobacilli population was significantly decreased (p<0.05) in ID rats compared to the CD group. Further, a significant decrease in the lactobacilli population was observed in Pb exposed rats irrespective of the dietary regimen. Upon withdrawal of Pb exposure, lactobacilli increased significantly in both the CD+Pb and ID+Pb groups, whereas re-exposure to Pb decreased lactobacilli population. The E. coli and yeast populations were inconsistent among both the ID and Pb exposed rats compared to controls. Fecal Pb levels increased significantly in Pb exposed rats irrespective of diet. Conclusion: An additive effect of dietary Fe deficiency and oral Pb exposure resulted in greater reductions in the intestinal lactobacilli population compared to either treatment alone. In addition, transient withdrawal of Pb exposure led to improved lactobacilli population irrespective of Fe status.

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Oral Lead Exposure Induces Dysbacteriosis in Rats

Cited by 18 publications

References 37 publications

Effects of subchronic oral toxic metal exposure on the intestinal microbiota of mice

Effects of subchronic oral toxic metal exposure on the intestinal microbiota of mice

Heterogeneous Composites on the Basis of Microbial Cells and Nanostructured Carbonized Sorbents

The effect of lead (Pb) exposure and iron (Fe) deficiency on intestinal lactobacilli, E. coli and yeast: A study in experimental rats

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