Oral leishmaniasis associated with kala-azar

Abbas, Kamal; Toum, Isam A. El; Hassan, A.M. El

doi:10.1016/0030-4220(92)90103-w

Cited by 22 publications

(4 citation statements)

References 4 publications

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“…Many organisms, mainly bacteria, may colonize gingival crevices causing periodontal disease at different degrees according to the amount of the invading organism and the capability of host response to its presence (Phelan et al, 1987). Regarding other parasites, oral Leishmania associated to chronic periodontal disease in patients with Kala-azar has been reported (Abbas et al, 1992). In addition, Leishmania DNA has been detected in oral samples taken from patients with periodontal inflammation years after they were clinically cured for cutaneous leishmaniasis (Añez et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Trypanosoma cruzi persistence at oral inflammatory foci in chronic chagasic patients

et al. 2011

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a b s t r a c tThe persistence of Trypanosoma cruzi in seropositive individuals, previously diagnosed as chronic chagasic patients (CCP), was detected for the first time in biopsies taken from gingival inflammatory foci processed by polymerase chain reaction (PCR). Seven out of 31 (22.5%) gum samples from selected unquestionably CCP showing different degrees of gingival inflammation revealed T. cruzi-DNA using 3 specific PCR assays. All the included CCP had been diagnosed in previous studies carried out over the last 19 years. Samples of inflamed gums were recently taken from the indicated patients at: an outpatient hospital cardiac unit; a village where Chagas disease is endemic; and a specialized diagnostic research center, showing molecular evidence of parasite persistence in 17.6%, 42.8% and 14.3% of them, respectively. The relatively frequent parasite persistence, demonstrated here in oral inflammatory processes of treated and/or untreated patients bearing long term T. cruzi-infection, suggests the establishment of secondary small foci for the maintenance of hidden or inapparent chagasic infection. The easy and low-risk, non-invasive method to get the sample may add the use of gingival biopsy as a potential alternative diagnostic tool to confirm T. cruzi-infection in CCP. The significance of T. cruzi persistence as a primary cause of chronic Chagas disease and the proposal of this mechanism to explain the pathogenesis in CCP are considered.

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Section: Introductionmentioning

confidence: 99%

Trypanosoma cruzi persistence at oral inflammatory foci in chronic chagasic patients

et al. 2011

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“…Leishmaniasis consists of a group of diseases caused by different species of protozoan parasites belonging to the genus Leishmania . The parasites occur as flagellates, known as promastigotes in the sandfly and as amastigotes inside tissue histiocytes of mammalian hosts in culture 1–3 . Leishmania (Viannia) braziliensis is among the most common species causing the disease in Brazil, which is called American tegumentary leishmaniasis and is endemic in the country.…”

Section: Introductionmentioning

confidence: 99%

Disseminated mucocutaneous leishmaniasis resulting from chronic use of corticosteroid

et al. 2003

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Mucocutaneous leishmaniasis is a granulomatous disease clinically characterized by ulcerated skin and mucosal lesions whose clinical manifestations can regress spontaneously, but with possible long subclinical evolution. The course of the disease is often related to the host immune response. The purpose of this article is to describe the clinical and microscopic findings of cutaneous and mucosal lesions of mucocutaneous leishmaniasis in a patient who presented an unusual form of the disease associated with an immunosuppressive state.

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“…17 Gingival hypertrophy and the false deep pockets will definitely lead to periodontitis and loss of teeth. 4 Our patient is from eastern Sudan, which is a well-known endemic area for VL and is endemic for HIV infection. The HIV/AIDS prevalence rate among the general population in the Sudan is on the increase.…”

Section: Discussionmentioning

confidence: 99%

“…2,3 In many areas endemic for leishmaniasis, ML is usually accompanied by a cutaneus or a visceral form of the disease. 4 Although ML is frequent in the New World, few cases are reported in the Old World. 1,[5][6][7][8] In Sudan, ML occurs as a primary mucosal disease that is not preceded or accompanied by a cutaneous lesion.…”

Section: Introductionmentioning

confidence: 99%

Mucosal Leishmaniasis in a Sudanese Patient

Abbas¹,

Musatafa²,

Abass³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

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Mucosal leishmaniasis (ML) is an oral disease caused by the parasite Leishmania donovani. The disease has been proven to be pandemic in many areas of the world. It affects young men living in leishmaniasis-endemic areas. ML might be accompanied or proceeded by visceral leishmaniasis (VL), although in most of the cases seen in Sudan, ML occurs as a primary lesion. ML can mimic oral cancer or fungal infections, with ulceration as the most common finding in ML lesions. In this report, the patient came from an area known to be endemic for VL. Although the lesions were not ulcerative, the patient history was indicative for ML. Early detection and proper diagnosis were of great help in the cure and prognosis of the disease.

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Oral leishmaniasis associated with kala-azar

Cited by 22 publications

References 4 publications

Trypanosoma cruzi persistence at oral inflammatory foci in chronic chagasic patients

Trypanosoma cruzi persistence at oral inflammatory foci in chronic chagasic patients

Disseminated mucocutaneous leishmaniasis resulting from chronic use of corticosteroid

Mucosal Leishmaniasis in a Sudanese Patient

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