Oral lesions after COVID-19 vaccination: Immune mechanisms and clinical approach

Tabari, Mohammad Amin Khazeei; Najary, Shaghayegh; Khadivi, Gita; Yousefi, Mohammad Javad; Samieefar, Noosha; Abdollahimajd, Fahimeh

doi:10.1016/j.imj.2022.06.004

Cited by 10 publications

(20 citation statements)

References 40 publications

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“…As a matter of fact, presented data may concomitantly suggest that subjects suffering from autoimmune disorders, as well as those with latent herpes simplex type 1 and varicella zoster virus infections [ 41 ] may be at risk of disease exacerbation and infection reactivation following anti-SARS-CoV-2 vaccination. Moreover, even if not focused on the genesis of oral lesions, presented results may indirectly disclose putative pathogenic mechanisms potentially underlying ADRs showing at least a temporal relation with the anti-SARS-CoV-2 vaccine administration [ 46 ] and involving the oral mucosa.…”

Section: Discussionmentioning

confidence: 99%

Oral Lesions Following Anti-SARS-CoV-2 Vaccination: A Systematic Review

Spirito

Amato

Palo

et al. 2022

IJERPH

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Increasing evidence relate anti-SARS-CoV-2 vaccinations to orofacial adverse reactions, therefore, the present systematic review aimed to evaluate primary oral lesions diagnosed in adult subjects, following the WHO Emergency Use Listing approved and EMA authorized vaccines, also in relation to cases’ age, gender, comorbidities, and history of COVID-19, and in relation to vaccine type and doses. The study protocol, registered on PROSPERO (CRD42022339032) and compliant with the PRISMA statement, included an electronic search across Scopus, MEDLINE/PubMed, BioMed Central databases, and PROSPERO, ended on 18 June 2022 and succeeded by a manual search, an independent data extraction, and arisk of bias evaluation through ROBINS-I tool. Qualitatively synthesized data from the 13studies included showed an overall low prevalence (16 cases), though higher in females (68.8%), of oral lesions, mainly erosions and ulcers (34.5%). Nine cases were diagnosed following Pfizer-BioNTech, two Moderna, and one AstraZeneca, Serum Institute of India, Sinopharm, and Johnson&Johnson vaccines, respectively; specifically, eight after the first dose and seven after the second. In one case, vaccine type and dose were not specified. Considering newly developing vaccines, presented findings may be updated and further studies needed to highlight factors affecting oral lesion occurrence and specific macro-microscopic phenotypes in relation to cases’ and vaccines’ characteristics.

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Section: Discussionmentioning

confidence: 99%

Oral Lesions Following Anti-SARS-CoV-2 Vaccination: A Systematic Review

Spirito

Amato

Palo

et al. 2022

IJERPH

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“…• Autoimmunologic reaction 89 • Mucocutaneous adverse reaction 90 • White plaques 70 Attenuated or inactivated virus Sinopharm (BBIBP-CorV) -Autoimmunologic reaction. 91 erythema multiforme 92 • Erosions and erythematous lesions 91 mRNA-based vaccines…”

Section: Oral Manifestations Of Thrombocytopeniamentioning

confidence: 99%

“…More serious complications, including stroke, renal failure, myocarditis, and lung fibrosis have also been reported 64 . Symptoms more related to the oral cavity have also been recorded, such as oral lesions, mucositis, petechiae, oral mucosal paresthesia or hypoesthesia, candida infection, and necrotizing gingivitis 12,65 . The exact underlying mechanisms behind such oral manifestations have yet remained to be thoroughly explained.…”

Section: The Badmentioning

confidence: 99%

“… 64 Symptoms more related to the oral cavity have also been recorded, such as oral lesions, mucositis, petechiae, oral mucosal paresthesia or hypoesthesia, candida infection, and necrotizing gingivitis. 12 , 65 The exact underlying mechanisms behind such oral manifestations have yet remained to be thoroughly explained. However, some studies suggest the potential of direct SARS‐CoV‐2 invasion of oral keratinocytes, fibroblasts, tongue, and salivary gland epithelial cells as the etiopathogenic mechanism underlying SARS‐CoV‐2 oral adverse effects.…”

Section: The Badmentioning

confidence: 99%

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A comprehensive review of oral microenvironment changes and orofacial adverse reactions after COVID‐19 vaccination: The good, the bad, and the ugly

Najary,

Vatankhah,

Khadivi

et al. 2024

Health Science Reports

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Background and AimsAnti‐severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines have the potential to alter several biological systems concurrently with remolding the immune system, most of which are related to immunization, while some others are known as adverse effects. This review aims to explore the potential effects of vaccination on the oral microenvironment and classifies them as good, bad, or ugly, with a brief review of facial diseases following coronavirus disease 2019 (COVID‐19) vaccination.MethodsThis study was a comprehensive review conducted through searching related articles in Medline, Scopus, and Google Scholar databases.ResultsOn one side, the “Good” impacts of vaccination on the oro‐nasal mucosa are explained as if the mucosal immune responses followed by SARS‐CoV‐2 vaccines are enough to provide immunity. On the other side, the possible “Bad” and “Ugly” effects of the vaccine, which manifest as orofacial adverse events and autoimmune reactivations, respectively, should be noted. Exacerbation of pre‐existing autoimmune conditions such as lichen planus, pemphigus vulgaris, bullous pemphigoid, and Stevens‐Johnson syndrome have been reported.ConclusionCOVID‐19 vaccines could affect different biological systems alongside stimulating the immune system, and some of these effects are referred to as adverse effects. Nonetheless, these adverse effects are treatable, and healthcare professionals should not prevent patients from taking the first available vaccination.

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“…In addition to citations, the published articles have been downloaded a total of 96,100 times, with 18 of the 42 articles being downloaded more than 1000 times. The most downloaded article (16,000 times) was about oral lesions and immune mechanisms after COVID-19 vaccination, submitted by the University of Medical Sciences of Mazandaran in Iran [3] . The United States was the region with the highest number of downloads, with over 50,000 downloads.…”

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confidence: 99%

The Infectious Medicine is becoming a globally high-level scientific journal

2024

Infectious Medicine

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Oral lesions after COVID-19 vaccination: Immune mechanisms and clinical approach

Cited by 10 publications

References 40 publications

Oral Lesions Following Anti-SARS-CoV-2 Vaccination: A Systematic Review

Oral Lesions Following Anti-SARS-CoV-2 Vaccination: A Systematic Review

A comprehensive review of oral microenvironment changes and orofacial adverse reactions after COVID‐19 vaccination: The good, the bad, and the ugly

The Infectious Medicine is becoming a globally high-level scientific journal

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