Oral lesions are frequent in patients with Chikungunya infection

Casais, P.; Akrami, Kevan; Cerqueira‐Silva, Thiago; Moraes, Laise P; Rigaud, Victor N; Neto, Emílio S; Orge, Cibele; Gusmão, L; Cavalcanti, Luciano Pamplona de Góes; Santos, Luciane Amorim; Barral‐Netto, Manoel; Barral, Aldina; Khouri, Ricardo; Boaventura, Viviane

doi:10.1093/jtm/taaa040

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…The 27 articles selected were on studies conducted in India [ 4 , 10 – 21 ], Reunion Island [ 22 – 25 ], Sri Lanka [ 26 ], Germany [ 27 ], France [ 28 ], Colombia [ 29 ], Grenada [ 30 ], Bangladesh [ 31 ], Brazil [ 32 – 33 ], Pakistan [ 34 ], and Nicaragua [ 35 ], published from 2007 to 2020.…”

Section: Resultsmentioning

confidence: 99%

“…Considering the 27 studies included in this systematic review, it was possible to survey data on a total of 7,023 suspected cases of chikungunya. We could extract data from 3,854 suspected cases of chikungunya reported in 8 studies [ 4 , 10 , 12 – 14 , 20 , 21 , 26 ] and from 2,611 laboratory-confirmed cases of chikungunya reported in 18 studies [ 11 , 15 – 19 , 22 – 25 , 27 – 30 , 32 – 35 ]. A study of 1,089 participants did not report the diagnostic criteria used for determining the disease [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…All studies were considered moderate risk of bias since they provided explanation on methodology. A total of 21 cohort studies were assessed [ 4 , 10 – 13 , 15 – 20 , 22 – 29 , 32 , 35 ] and 6 cross-sectional studies [ 14 , 21 , 30 , 31 , 33 , 34 ]. The scores attributed to studies ranged between 5 and 7 stars.…”

Section: Resultsmentioning

confidence: 99%

“…It is important to note the presence of active CHIKV in the saliva of human patients with acute infection. This evidence claims that the viral agent in saliva may be associated with hemorrhagic lesions in the nasal/oral cavities during the viremic period and points out the importance of the relationship for clinical practice and management of the patient with chikungunya by the dentist [ 32 – 35 ]. In a study with 105 confirmed cases for chikungunya, CHIKV was isolated in the saliva of 27% of the cases with the presence of oral manifestations [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

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Oral manifestations in chikungunya patients: A systematic review

et al. 2021

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Background Chikungunya fever is considered an abrupt onset arbovirus transmitted by mosquitoes, mainly Aedes aegypti and Aedes albopictus. The disease has a significant impact on the quality of life of affected persons, and many of its numerous symptoms have not yet been properly clarified, such as the manifestations that can occur in the oral cavity. The aim of this study was to identify the main oral manifestations related to chikungunya fever, as well as describe the demographic characteristics of patients, by conducting a systematic review of the literature. Methods and findings Searches were performed in MEDLINE (PubMed), Embase (Elsevier), LILACS (VHL), Cochrane Library, Scopus, and CAPES electronic databases for theses and dissertations published up to January 16, 2021 without language and date restrictions. Additional manual searches of gray literature, reference list, and Google Scholar were carried out. We included 27 studies highlighting mainly oral manifestations that cause masticatory discomfort such as ulcers and oral thrush, gingival bleeding, pain and burning of the oral mucous membranes, temporomandibular joint (TMJ) arthralgia, opportunistic infections, and changes in taste. Conclusions There seems to be a predominance of oral manifestations that cause discomfort when chewing, such as ulcerations in the acute phase of the disease, with complete remission within 3 to 10 days after the onset, apparently mostly affecting women and older persons. These oral manifestations can be compatible with basic viral infections related to inflammatory response and transitory immunosuppression.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Oral manifestations in chikungunya patients: A systematic review

et al. 2021

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“…Not many studies have examined this but those that did, they focused on examination of oral manifestations of chikungunya. Oral lesions common in chikungunya with gingival bleeding amongst the top few manifestations [ 38 , 49 , 50 ]. However, bleeding manifestations are more often associated with dengue [ 34 ] that are less common in chikungunya [ 51 ] and despite significant association with chikungunya, it would not be clinically apt to use it as its predictor in a dengue–chikungunya syndemic setting.…”

Section: Discussionmentioning

confidence: 99%

Joint Involvement Can Predict Chikungunya in a Dengue Syndemic Setting in India

Sinha,

Savargaonkar,

et al. 2023

J Epidemiol Glob Health

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Dengue and chikungunya have been endemic in India but have the tendency to cause periodic epidemics, often together, wherein they are termed ‘syndemic’. Such a syndemic was observed in 2016 in India which resulted in a further scarcity of already resource-poor specific diagnostic infrastructure even in many urban conglomerates. A cross-sectional study was thus conducted, on 978 fever patients that consulted the ICMR-NIMR fever clinic, New Delhi, in September 2016, with an objective to identify symptom/s that could predict chikungunya with certainty. The overall aim was to rationally channelize the most clinically suitable patients for the required specific diagnosis of chikungunya. Based on their clinical profile, febrile patients attending NIMR’s clinic, appropriate laboratory tests and their association analyses were performed. Bivariate analysis on 34 clinical parameters revealed that joint pain, joint swelling, rashes, red spots, weakness, itching, loss of taste, red eyes, and bleeding gums were found to be statistically significantly associated predictors of chikungunya as compared to dengue. While, in multivariate analysis, only four symptoms (joint pain in elbows, joint swelling, itching and bleeding gums) were found in statistically significant association with chikungunya. Hence, based on the results, a clinician may preferably channelize febrile patients with one or more of these four symptoms for chikungunya-specific diagnosis and divert the rest for dengue lab diagnosis in a dengue–chikungunya syndemic setting.

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Dermatoses of the Oral Cavity and Lips

Carey,

Setterfield

2024

Rook's Textbook of Dermatology

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Oral lesions are frequent in patients with Chikungunya infection

Cited by 7 publications

References 9 publications

Oral manifestations in chikungunya patients: A systematic review

Oral manifestations in chikungunya patients: A systematic review

Joint Involvement Can Predict Chikungunya in a Dengue Syndemic Setting in India

Dermatoses of the Oral Cavity and Lips

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