Oral lesions in patients with COVID-19 hospitalized in an intensive care unit: a case-series study

Abstract

This study evaluated the presence of oral lesions in patients with COVID-19 hospitalized in an intensive care unit (ICU). Data included demographic, clinical, and laboratory information. Clinical assessment of the oral cavity was performed on the 2 nd and 5 th days of orotracheal intubation. Thirty-eight patients were evaluated and 16 (42.1%) presented oral lesions during their ICU stay. The median age and length of stay were 75 years and 15 days, respectively. Among the patients with oral lesions, ulcerative oral lesions were reported in 14 (87.5%) patients, of which 11 (78.6%) were found on the lips. This study highlights the importance of oral examination for patients admitted to the ICU with COVID-19.

The Oral Lesion in the COVID-19 Patient: Is It True Oral Manifestation or Not?

“…Related to underlying diseases, diabetes mellitus is reported as a common condition found, 41 , 58 , 61 , 62 and hypertension, 41 , 55 , 58 , 61 , 62 cardiovascular disease, 41 , 58 , 62 asthma, 55 , 58 , 61 obesity 41 , 58 and renal disease. 41 , 62 The medication-related to the oral lesion was antibiotic, 41 , 62 anticoagulant, 41 , 62 antimalarial, 58 , 62 antiviral, 55 , 58 , 62 and corticosteroids. 41 , 55 , 62 Other underlying diseases and medications are listed in Table 7 .…”

“… 41 , 62 The medication-related to the oral lesion was antibiotic, 41 , 62 anticoagulant, 41 , 62 antimalarial, 58 , 62 antiviral, 55 , 58 , 62 and corticosteroids. 41 , 55 , 62 Other underlying diseases and medications are listed in Table 7 .…”

“…The oral lesion was found as an ulcer, 41 , 55 , 58 , 61 , 62 atrophy, pseudomembrane, 55 , 61 , 62 erosion, 41 , 55 , 61 macula, 55 , 62 petechiae 61 , 62 vesico-bullous, 61 , 62 crust, depapilation, ecchymosis, and 41 papule. 55 …”

Terapia Fotodinâmica no tratamento de lesões bucais em pacientes com COVID-19 em UTI: Relato de dois casos

“…Em nosso relato de caso apresentamos dois pacientes com ulcerações hemorrágicas, condição mais comum encontrada em pacientes graves internados por COVID-19 (Brandão, et al, 2020;Batista, et al, 2022;Hocková, et al, 2021;Villarroel-Dorrego, et al, 2021). Pesquisa de Batista et al (2022) possibilidade de uma coinfecção. As infecções secundárias foram associadas à maior permanência na UTI, uso de VM e maior mortalidade (Costa, et al, 2022).…”

“…As alterações bucais de pacientes com COVID-19 têm sido variadas, com grande citação em estomatite aftosa, lesões virais herpetiformes, candidíase, vasculite, lesões tipo Kawasaki, lesões tipo Eritema multiforme, mucosite, erupção por droga e queilite angular (Bermúdez, et al, 2021;Iranmanesh, et al, 2021;Santos, et al, 2021;Villarroel-Dorrego, et al, 2022). No entanto, ainda não existe um consenso sobre a origem fisiopatológica dessas manifestações, as quais podem estar relacionadas aos medicamentos administrados durante o tratamento da infecção por SARS-CoV-2, ao quadro de imunossupressão, infecções secundárias (Batista, et al, 2022;Costa, et al, 2022;Fernandes, et al, 2021;Ripa, et al, 2021;Santos, et al, 2020), complicações iatrogênicas, infecção viral direta, estresse ou fatores sistêmicos subjacentes (Bermúdez, et al, 2021;Fernandes, et al, 2021;Iranmanesh, et al, 2021;Hocková, et al, 2021).…”