Oral lesions indicative of plasminogen deficiency (hypoplasminogenemia)

Destructive membranous periodontal disease (ligneous periodontitis): a case report and 3 years follow-up

“…3 Scully et al stated that the reported cases might fall within a spectrum of disorders related to plasminogen deficiency and very closely related with ligneous conjunctivitis, but distinct from it, because few patients had lesions of other mucosae and the gingival deposits had different staining characteristics. 4 The gingival lesions reported in association with this entity reveal that they were progressive and usually end with loss of teeth. [2][3][4]6 Several surgical and periodontal treatment efforts were unsuccessful in all the reported oral lesions.…”

“…4 The gingival lesions reported in association with this entity reveal that they were progressive and usually end with loss of teeth. [2][3][4]6 Several surgical and periodontal treatment efforts were unsuccessful in all the reported oral lesions. [2][3][4]6 In some cases, gingival lesions show regression or disappear following tooth loss, 3 but there is not any reported period for the regression of the lesions in the literature.…”

“…In most instances, ligneous conjunctivitis might represent an autosomal recessive disorder. 4 Since 1997, Schuster et al demonstrated distinct homozygous and compound-heterozygous mutations in the plasminogen gene to be common in patients with ligneous conjunctivitis and clearly confirmed autosomal-recessive inheritance of this disorder. 5 Most of the reported oral lesions were seen together with ligneous eyelid lesions.…”

“…3 The cause of this condition is due to plasminogen deficiency and resultant fibrin deposition. 2,4 The periodontal lesions are produced by the same process that causes ligneous conjunctivitis. In most instances, ligneous conjunctivitis might represent an autosomal recessive disorder.…”

“…However, only a few of the reported cases of ligneous conjunctivitis have coexisted with oral and dermatological lesions. 3,4,6 Therefore, patients with destructive membranous lesions of the periodontal tissues should always be systemically evaluated and should be thoroughly examined for possible involvement of the skin and other mucosal surfaces. In the reported case, oral and eyelid lesions were seen together but there were not any dermatological lesions related with the disease.…”