Oral lichen planus

Jungell, Peter

doi:10.1016/s0901-5027(05)80001-3

Cited by 67 publications

(33 citation statements)

References 120 publications

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“…Oral lichen planus (OLP), a chronic inflammatory disease, is estimated to occur in 0.2-3% of the population [1,2]. Six clinical forms of OLP have been described as reticulated, plaque-like, erosive, papular, atrophic, and bullous [3].…”

Section: Introductionmentioning

confidence: 99%

Treatment of oral lichen planus with the 308‐nm UVB excimer laser—early preliminary results in eight patients

et al. 2003

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Section: Introductionmentioning

confidence: 99%

Treatment of oral lichen planus with the 308‐nm UVB excimer laser—early preliminary results in eight patients

et al. 2003

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“…Pussey 13 From the accumulated data in the literature, it is evident that the buccal mucosa is the commonest site affected. This has been stated by workers like Jungell, 23 Andreasen, 9 Shklar and McGrathy, 15 Sehgal. 22 In our study too, the buccal mucosa was the site most frequency involved (81.8%).…”

Section: Discussionmentioning

confidence: 67%

A Clinicohistopathologic Study and Probable Mechanism of Pigmentation in Oral Lichen Planus

Anjum¹,

Singh²,

Kudva³

2012

World Journal of Dentistry

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Aim: Probable mechanism of pigmentation in oral lichen planus which is associated with anxiety disorder and its relation to gamma aminobutyric acid whose imbalance in brain occurs during stress and strain. Materials and methods:A cross-sectional study comprising of 33 cases of clinically diagnosed oral lichen planus was conducted. Ethical clearance and informed consent was obtained. Detailed history was recorded and clinical examination was conducted. All patients were subjected to thorough routine blood, urine and stool examination for any systemic conditions. Clinical photographs and biopsies were obtained. The biopsy specimens were subjected to hematoxylin and eosin and periodic acid Schiff's reagent staining.Results: Histopathological features of lichen planus include hyperkeratosis, liquefaction degeneration of stratum basale and subepithelial band of chronic inflammatory cells. Lichen planus is related to anxiety as predisposing factor. Conclusion:Due to excitation of melanocytes lichen planus are seen with pigmentation.

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“…Oral LP (OLP) may exist whithersoever in the oral cavity. The buccal mucosa, tongue and gingival are the most common sites, whereas palatal lesions are uncommon (2,3). It is seen worldwide, mostly in the fifth to sixth decades of life, and is twice as common in women than in men (1,3,4).…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of Topical Pimecrolimus in the Treatment of Oral Lichen Planus

Mülayim¹,

Öztürk²,

Uzun³

2016

tdd

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Objectives: Oral lichen planus (OLP) is a chronic inflammatory disorder of unknown etiology that affects the skin and the mucosa, especially the oral mucosa. Several therapeutic agents have been investigated for the treatment of OLP. All agents used in the OLP therapy are palliative. Potent topical steroids are used as the conventional therapy for OLP. Since side-effects or steroid resistance may be encountered, alternative treatments may be necessary. This study aimed to evaluate the efficacy and safety of the topical pimecrolimus in the treatment of OLP. Methods: Seventeen patients with OLP were recruited into this study. Topical pimecrolimus 1% cream was applied twice a day to the affected areas. Patients were followed up for 3-6 months. Photographs of the lesions were taken and analyzed for areas of ulceration, erythema, and reticulation in every clinical examination. Results: We found that topical pimecrolimus 1% cream was an effective treatment for OLP. Two patients could not complete the treatment protocol because of the side effects such as local irritation and nausea. Conclusion: Topical pimecrolimus may be a valuable second treatment choice for patients with steroid-related side-effects or steroid-resistant OLP. However further randomized controlled studies have to be conducted to compare conventional treatment of topical corticosteroid with topical pimecrolimus. Keywords: Oral lichen planus, pimecrolimus, calcineurin inhibitor, treatment, efficacy, safety Öz Abstract Amaç: Oral liken planus (OLP) deri ve mukozaları özellikle de oral mukozayı tutan, etiyolojisi bilinmeyen kronik enflamatuvar bir hastalıktır. OLP tedavisi için birkaç terapötik ajan araştırılmıştır. OLP'nin tedavisinde kullanılan bütün ajanlar palyatif etkilidir. OLP'nin geleneksel tedavisinde potent topikal steroidler kullanılır. Steroidlerin yan etkileri veya steroide direnç ile karşılaşılabileceğinden alternatif tedaviler gerekli olabilir. Bu çalışmada topikal pimekrolimusun OLP'nin tedavisindeki etkinliğini ve güvenirliğini değerlendirmek amaçlandı. Yöntemler: OLP'li 17 hasta çalışmaya alındı. Topikal pimekrolimus %1 krem etkilenmiş bölgelere günde 2 kez uygulandı. Hastalar 3-6 ay süreyle aylık olarak takip edildi. Her kontrolde lezyonların fotoğrafı çekilerek ülserasyon, eritem ve ağ yapısı gibi özellikleri değerlendirildi. Bulgular: Biz OLP'nin tedavisinde topikal %1 pimekrolimusu etkili bulduk. Çalışmaya alınan iki hasta bulantı hissi ve lokal irritasyon gibi yan etkiler nedeni ile tedavi protokolünü tamamlayamadı. Sonuç: Topikal pimekrolimus, steroid ile ilişkili yan etkileri olan hastalarda veya steroide dirençli OLP'nin tedavisinde ikinci seçenek olarak düşünülebilir. Ancak etkinliği tam olarak değerlendirebilmek için OLP'nin geleneksel tedavisi olan topikal steroid ile topikal pimekrolimusun karşılaştırmalı, randomize, kontrollü çalışmaları yapılmalıdır.

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Oral lichen planus

Cited by 67 publications

References 120 publications

Treatment of oral lichen planus with the 308‐nm UVB excimer laser—early preliminary results in eight patients

Treatment of oral lichen planus with the 308‐nm UVB excimer laser—early preliminary results in eight patients

A Clinicohistopathologic Study and Probable Mechanism of Pigmentation in Oral Lichen Planus

The Effectiveness of Topical Pimecrolimus in the Treatment of Oral Lichen Planus

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