Oral Lichen Planus and Hepatitis C virus Infection: an Epidemiological Study of 149 Cases

Hakkou, Fouzia; Chbicheb, Saliha; Essaid, E. A.; Wady, Wafaa El

doi:10.4067/s0718-381x2012000200008

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…From forty-nine studies, the overall pooled prevalence of LP in HCV patients was 7.05% (95% CI, 4.85–9.26%). From these, in thirty-four cohorts, the overall pooled prevalence of LP was 7.75 (95% CI 4.84–10.66%) in patients with HCV [ 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 206 ]. Detailed information on the sample to the included studies is provided in Supplemental Table S2 .…”

Section: Resultsmentioning

confidence: 99%

Bidirectional Association between Lichen Planus and Hepatitis C—An Update Systematic Review and Meta-Analysis

García-Pola,

Rodríguez-Fonseca,

Suárez-Fernández

et al. 2023

JCM

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Lichen planus (LP) is a chronic, inflammatory mucocutaneous disorder associated with systemic diseases such as hepatitis C (HCV). The objective of this study is to evaluate the association between LP and HCV bidirectionally through a systematic review and meta-analysis. A comprehensive search of studies published was performed in the databases of PubMed, Embase, and Web of Science. Out of 18,491 articles, 192 studies were included. The global prevalence of HCV positive (HCV+) in LP patients registered from 143 studies was 9.42% [95% confidence interval (CI), 7.27–11.58%], and from these, 84 studies showed HCV+ 4-fold more frequent in LP than a control group (OR, 4.48; 95% CI, 3.48–5.77). The global prevalence of LP in patients HCV+ recorded from 49 studies was 7.05% (95% CI, 4.85–9.26%), and from these, 15 registered a 3-fold more LP in HCV (OR, 3.65; 95% CI, 2.14–6.24). HCV+ in LP patients showed great geographic variability (OR, 2.7 to 8.57), and the predominantly cutaneous location was higher (OR, 5.95) than the oral location (OR, 3.49). LP in HCV+ patients was more frequent in the Eastern Mediterranean (OR, 5.51; 95% CI, 1.40–15.57). There is a higher prevalence of HCV+ in LP and vice versa than in the control group, especially in certain geographical areas that should be taken into consideration when doing screening in countries with an upper prevalence of HCV among the general population.

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Section: Resultsmentioning

confidence: 99%

Bidirectional Association between Lichen Planus and Hepatitis C—An Update Systematic Review and Meta-Analysis

García-Pola,

Rodríguez-Fonseca,

Suárez-Fernández

et al. 2023

JCM

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“…A large proportion of these chronically infected patients without symptom for HCV infection and becomes carriers. OLP in certain individuals can be used as a marker for diagnosis of HCV infection in asymptomatic patients, leading to early therapy and best prognosis (11) . It has been estimated that HCVinfected patients have at least twice the risk of progress LP than the general population.…”

Section: Introductionmentioning

confidence: 99%

Detection of Hepatitis C Virus in Iraqi Patients With Oral Lichen Planus

2016

IJMS

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Background Oral Lichen planus (OLP) is chronic mucocutaneous disorder with or without involvement skin, of unknown etiology. Lichen planus (LP) is T-cell-mediated chronic inflammatory disease of the stratified squamous epithelium. It can affect oral mucosa, skin, esophagus, nasal mucosa, larynx, genitalia, urinary tract, hair follicles and the eyes. Latterly has been focused on presence association between OLP and hepatitis C virus (HCV) infection, but this relation is not stable, since the prevalence of this virus in patients varies depended on studies, ranging from 0% to 67.8%. ObjectiveThis study was established to investigate the relationship between the OLP and HCV infection in Iraq and to detect the virus by Real-time polymerase chain reaction (RT-PCR). MethodsBlood samples were collected from 62 patients with OLP and controls to detect the HCV in those patients by using one step anti-HCV test, ELISA test and RT-PCR. ResultsThe current study revealed that the early detection of HCV by one step Anti-HCV for all OLP patients was negative and by ELISA showed that four patients (12.5%) of OLP were positive for HCV. While using RT-PCR found that only one patient (3.1%) was positive for the presence of the virus. ConclusionThere was not relationship found between OLP and HCV infection in Iraqi patients.

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Oral Lichen Planus and Hepatitis C virus Infection: an Epidemiological Study of 149 Cases

Cited by 2 publications

References 22 publications

Bidirectional Association between Lichen Planus and Hepatitis C—An Update Systematic Review and Meta-Analysis

Bidirectional Association between Lichen Planus and Hepatitis C—An Update Systematic Review and Meta-Analysis

Detection of Hepatitis C Virus in Iraqi Patients With Oral Lichen Planus

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