Oral lichen planus and intake of drugs metabolized by polymorphic cytochrome P450 enzymes

Kragelund, Camilla; Thomsen, CE; Bardow, A; Pedersen, AM; Nauntofte, Birgitte; Reibel, Jesper; Torpet, Lis Andersen

doi:10.1034/j.1601-0825.2003.02892.x

Cited by 24 publications

(28 citation statements)

References 61 publications

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“…The clinical profile of the OLP patients in this study shares many similarities with those reported by other authors, in terms of female predominance (female/male ratio 3.8:1), age of diagnosis (predominantly over 50 years) and the clinical pattern of the lesions (predominance of the reticular form with bilateral distribution) (4,(13)(14)(15).…”

Section: Discussionsupporting

confidence: 70%

“…The female predominance reported in the present study was even higher than those found in other studies (4,10,(14)(15)(16), in which the female/male ratio varied from 1.5:1 to 2.1:1. One possible explanation for this difference is that, routinely, more women (64.5%) than men (35.5%) come to our clinic for a diagnosis of some type oral mu- (3,9,17).…”

Section: Discussioncontrasting

confidence: 56%

“…Of these 7 patients, 2 produced a recurrence when later rechallenged with the offending drug (9). There have been few articles comparing the profile of drug intake by OLP patients with that of a control group (4,10). The purpose of the present study was to investigate whether the daily systemic and/or topical medicine used by patients with OLP contributes to the development of their oral lesions.…”

Section: Introductionmentioning

confidence: 99%

“…Oral lichen planus (OLP) affects from 0.1 to about 4% of individuals, occurring mostly in middle-aged adults, with a female predominance at a ratio of approximately 2:1 (3,4). Several studies have suggested a possible relationship between OLP and daily intake of medicine (3,(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

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Analysis of a possible association between oral lichen planus and drug intake. A controlled study

Hirota

Moreno²,

Santos³

et al. 2011

Med Oral

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Objectives: To investigate whether daily systemic and/or topical medication contributes to the development of oral lichen planus (OLP) lesions. Study Design: The study involved 110 OLP patients and 76 control subjects, matched by age, race and sex. The analyzed data included medical records, drug intake and topical medication. Criteria for analysis of drug intake included: (1) ATC-code drug classification; (2) number of different drugs used daily in the categories of monopharmacy (1 drug), minor polypharmacy (2-4 drugs), and major polypharmacy (> 5 drugs); and (3) drugs implicated in lichenoid reactions (DILRs). Results: Sixty (54.5%) of the 110 OLP patients reported daily medication (prior to the appearance of the OLP lesion) compared to 52 (68.4%) of the 76 control subjects. No statistical difference was found between the two groups in terms of systemic diseases, number of medicated individuals in the categories of mono-and polypharmacy, nor use of DILRs (P > 0.05). Regarding the clinical forms and site of involvement, a statistically significant difference was only found for the clinical erosive form of OLP, seen more frequently in non-DILR (P = 0.04) and nonmedicated OLP patients (P = 0.02) than in DILR OLP patients. Daily use of topical oral medication was reported by 2 (1.8%) OLP patients and 1 (1.3%) control subject. Conclusions: It seems that the use of systemic medication does not lead to a significant increase in the incidence of OLP lesions. For their part, lichenoid drug reactions are likely to occur only in a very low percentage of patients.

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Section: Discussionsupporting

confidence: 70%

Section: Discussioncontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Analysis of a possible association between oral lichen planus and drug intake. A controlled study

Hirota

Moreno²,

Santos³

et al. 2011

Med Oral

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“…Eleven of them had histological confirmation of all cases with distinguish between OLP and OLL [1,11,23,25,[27][28][29][30][31][32][33] and five presented with control group [11,13,24,25,27]. It can be noticed clear difference in reported coexistence of thyroid gland pathosis and OLP between Northern and Central European countries (Finland [11], Czech Republic [28] and Croatia [34]) and Southern Mediterranean countries (Italy [1,26] and Turkey [29]).…”

Section: Discussionmentioning

confidence: 99%

Association of Oral Lichen Planus with Autoimmune Diseases in A Northern Serbia Population: Matched Case-Control Study and Literature Review

Čanković¹

2016

J. Dent. Sci. Ther

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Oral lichen planus (OLP) is a still poorly understood and relatively common chronic inflammatory disease of oral mucosa. A connection between OLP and certain diseases have been reported in the past, such as diabetes, hypertension, hepatitis C infection (HCV), thyroid disease, and malignant diseases. There is some controversial about mentioned link with OLP. The study objective was to investigate association between autoimmune diseases and OLP in Northern Serbian province. A total of 48 patients (33 females and 15 males, ranged 29-84 years, mean age 59.8 ± 13.0) with clinical and histopathological proven OLP, along with 71 matched controls without oral mucosa lesions were included in the study. This was a retrospective case-control study conducted in patients who were treated at the Dental Clinic, Faculty of Medicine, University of Novi Sad, between January 2010 and Jun 2016. Clinical characteristics of OLP lesions, other oral mucosal diseases, presence of cutaneous LP, medical and family history with special regard to their autoimmune diseases with medication intake were recorded. Association regarding total of autoimmune diseases was found significant especially in prevalence of thyroid gland diseases. This study indicates connection between thyroid gland disorders (Hashimoto thyroiditis) and OLP. There is a need for further investigations such a screening for asymptomatic OLP in woman over the 40 years old suffering from thyroid gland disorders, particularly hypothyroidism.

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Lichen Planus and Lichenoid Disorders

Breathnach¹,

Black²

2004

Rook's Textbook of Dermatology

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Oral lichen planus and intake of drugs metabolized by polymorphic cytochrome P450 enzymes

Cited by 24 publications

References 61 publications

Analysis of a possible association between oral lichen planus and drug intake. A controlled study

Analysis of a possible association between oral lichen planus and drug intake. A controlled study

Association of Oral Lichen Planus with Autoimmune Diseases in A Northern Serbia Population: Matched Case-Control Study and Literature Review

Lichen Planus and Lichenoid Disorders

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