Oral lichen planus: clinical and histopathological considerations

Sousa, Fernando Augusto Cervantes Garcia de; Rosa, Leonardo Cruz da

doi:10.1016/s1808-8694(15)31102-2

Cited by 60 publications

(28 citation statements)

References 37 publications

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“…OLP are mostly polymorphic such as reticular type which is present as white striae known as Wickham’s striae often bilateral and asymptomatic. Erosive/atrophic (OLP) present as irregular ulceration, often associated with pain and burning sensation which is exacerbated by trauma, hot, spicy and acidic food (3). OLP pathogenesis is thought to be a T-cell mediated autoimmune disease involving specific and non-specific antigen specificity (4).…”

Section: Introductionmentioning

confidence: 99%

The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients

Othman

Shaker

Elshenawy³

et al. 2016

J Clin Exp Dent

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BackgroundOral lichen planus (OLP) is a common chronic inflammatory mucosal disease with a multifactorial etiology. It is a T-cell mediated autoimmune disease in which the cytotoxic CD8+T cells trigger apoptosis of the basal cells of oral epithelium. Various treatment regimens have been employed for management of symptomatic OLP. This study was carried out to evaluate the effect of topical steroids as well as laser on the clinical signs and symptoms detected by reticular, atrophic, erosive score (RAE score) and tumor necrosis factor- α (TNF-α) level in the serum of patients with symptomatic OLP.Material and MethodsThe study was conducted on twenty-four patients (18 females and 6 males) with symptomatic OLP that were allocated into two groups. Each included twelve patients. The first group treated either with diode laser (970nm SIROLaser Advance class IIIb, SIRONA The Dental Company, Germany) twice weekly with maximum of ten sessions while the second group were treated with topical corticosteroids (0.1% triamcinolone acetonide orabase, Kenacort-A Orabase Pomad, DEVA HOLDING A.Ș, Istanbul, Turkey) for four weeks.ResultsCorticosteroids group showed less clinical signs and symptoms of reticular, atrophic, erosive RAE score (p=0.02) and TNF-α serum level (p=0.028) than diode laser group with no reported therapy side effects or complications in any of the treated patients.ConclusionsTopical steroids reduce pain, reticular, atrophic, erosive RAE score and TNF-α serum level more than laser treatment. Moreover, laser treatment can be used as an alternative treatment when steroids are contraindicated for the treatment of symptomatic OLP. Key words:Oral lichen planus, diode laser, topical steroid, RAE score, TNF-α.

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Section: Introductionmentioning

confidence: 99%

The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients

Othman

Shaker

Elshenawy³

et al. 2016

J Clin Exp Dent

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“…Due to low [2, 4, 5] and rather questionable [6–8] risk for malignant transformation, OLP is classified as potentially malignant disorder [9]. Indeed, OLP has distinctive clinical features within the oral cavity with several characteristic morphological types and symmetrical distribution in oral mucosa [5, 6, 8]. These features facilitate clinical diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathologic Correlation of Oral Lichen Planus and Oral Lichenoid Lesions: A Preliminary Study

Stipetić

Brzak

Bakale-Hodak

et al. 2014

The Scientific World Journal

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Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are clinically and histologically similar lesions but their treatment planning and prognosis are different. The review of the literature indicates numerous criteria to distinguish these two lesions; however there is a lot of inconsistency. Thus, the aim of this study was to determine the correlation of histopathology and clinical OLP and OLL diagnosis and to clarify which histopathologic criteria could best distinguish these two diagnoses. A retrospective study showed that clinically diagnosed 92 OLPs and 14 OLLs have been confirmed histopathologically in 52.2% and 42.9% of cases, respectively. In addition, histopathology showed statistically significant more eosinophils (P < 0.0005), plasma cells (P < 0.0005), and granulocytes (P < 0.05) in OLL than OLP. To establish histopathological diagnosis of OLP and OLL it should be mandatory to define the type of cells in mononuclear infiltrate, which can be associated more accurately with clinical feature and patient history. Therefore, currently accepted diagnostic criteria for OLP and OLL should be modified and validated on a larger number of patients taking into account particular distinguishing histopathological features.

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“…[1] This condition was first described by Wilson in 1869. OLP affects 0.1-4% of the world's population and 1.5% of Indian population.…”

Section: Introductionmentioning

confidence: 99%

“…It is often associated with a burning sensation and pain and it is exacerbated by trauma and food particularly hot, spicy and acidic foods. [12]…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical assessment of proliferating cell nuclear antigen protein expression in plaque, reticular and erosive types of oral lichen planus

Pramod

Pandit²,

Desai³

et al. 2014

Ann Med Health Sci Res

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Background:Proliferating cell nuclear antigen (PCNA) is a nuclear protein synthesized in the late G1 and S-phase of the cell cycle. Immunodetection of this protein represents a useful marker of the proliferation status of lesions.Aims:The aim of this study is to evaluate the immunohistochemical expression of PCNA in oral lichen planus (OLP) and to assess the PCNA expression in a different layer of epithelium in different types of OLP.Subjects and Methods:A total of 96 cases of histologically proven OLP, 32 cases each of erosive, reticular and plaque type were selected. Two sections were taken from each one for H and E. Other sections were stained according to super sensitive polymer horseradish peroxidase method for identifying PCNA expression.Results:Of the three types of OLP, erosive type showed higher expression of PCNA (average 66.8%, minimum of 55% and maximum of 80.3%) followed by reticular (average 37.7%, minimum of 26% and maximum of 47%) and plaque type (average 17%, minimum of 5% and maximum of 25%) indicating increased proliferative activity. The erosive type also showed higher expression of PCNA in all the layers of epithelium followed by reticular and plaque type.Conclusion:PCNA is a good marker to indicate proliferation status of disease. Out of three types, erosive type possess more proliferative ratio, chances of malignant changes is more in this type.

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Oral lichen planus: clinical and histopathological considerations

Abstract: The possibility of this lesion to turn malignant justifies the importance of long term follow up for patients with such disease.

Cited by 60 publications

References 37 publications

The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients

The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients

Clinicopathologic Correlation of Oral Lichen Planus and Oral Lichenoid Lesions: A Preliminary Study

Immunohistochemical assessment of proliferating cell nuclear antigen protein expression in plaque, reticular and erosive types of oral lichen planus

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