Oral lichen planus to oral lichenoid lesions: Evolution or revolution

Dudhia, Bhavin B; Dudhia, Sonal B; Patel, Purv S; Jani, Yesha V

doi:10.4103/0973-029x.174632

Cited by 26 publications

(19 citation statements)

References 28 publications

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“…The epigenetic biomarkers, such as methylated genes could efficiently point to changes before cancers can be clinically detected and help us better understand tumorigenesis and hopefully improve cancer treatment and prevention [ 16 , 17 ]. Some of these potential biomarkers could also differentiate between the groups of potentially premalignant oral lesions that show possible premalignant transformation, such as oral lichen planus (OLP) and oral lichenoid lesions (OLL), whose treatment is different from each other despite their high clinical and histopathological similarities [ 18 , 19 , 20 ]. Namely, OLP is a chronic immunological mucocutaneous disorder of unknown etiology, while OLL is usually of known etiology, being a lichenoid contact stomatitis [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa

Gašperov

Sabol

Božinović

et al. 2020

IJMS

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There is a strong need to find new, good biomarkers of head and neck squamous cell carcinoma (HNSCC) because of the bad prognoses and high mortality rates. The aim of this study was to identify the potential biomarkers in HNSCC that have differences in their DNA methylome and potentially premalignant oral lesions, in comparison to healthy oral mucosa. In this study, 32 oral samples were tested: nine healthy oral mucosae, 13 HNSCC, and 10 oral lesions for DNA methylation by the Infinium MethylationEPIC BeadChip. Our findings showed that a panel of genes significantly hypermethylated in their promoters or specific sites in HNSCC samples in comparison to healthy oral samples, which are mainly oncogenes, receptor, and transcription factor genes, or genes included in cell cycle, transformation, apoptosis, and autophagy. A group of hypomethylated genes in HNSCC, in comparison to healthy oral mucosa, are mainly involved in the host immune response and transcriptional regulation. The results also showed significant differences in gene methylation between HNSCC and potentially premalignant oral lesions, as well as differently methylated genes that discriminate between oral lesions and healthy mucosa. The given methylation panels point to novel potential biomarkers for early diagnostics of HNSCC, as well as potentially premalignant oral lesions.

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Section: Introductionmentioning

confidence: 99%

DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa

Gašperov

Sabol

Božinović

et al. 2020

IJMS

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“…Lichen planus is a chronic mucocutaneous T cell mediated disease that usually involves the oral mucosa [ 1 ]. An antigen specific cell mediated immune response initiated by various chemokines and extracellular matrix proteins act through different pathways to cause degeneration of basal keratinocytes in the oral epithelium [ 2 ]. Clinically, OLP almost always occurs bilaterally.…”

Section: Introductionmentioning

confidence: 99%

Role of Mast Cells in Oral Lichen Planus and Oral Lichenoid Reactions

Suganya

Narasimhan

Harikrishnan

et al. 2018

Autoimmune Diseases

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Introduction Oral lichen planus (OLP) is a chronic T cell mediated disease of oral mucosa, skin, and its appendages with a prevalence of 0.5 to 2.6% worldwide. Oral lichenoid reactions (OLR) are a group of lesions with diverse aetiologies but have clinical and histological features similar to OLP, thereby posing a great challenge in differentiating both lesions. Mast cells are multifunctional immune cells that play a major role in the pathogenesis of lichen planus by release of certain chemical mediators. Increased mast cell densities with significant percentage of degranulation have been observed as a consistent finding in pathogenesis of oral lichen planus. Aim The current study was aimed at quantifying the mast cells in histopathological sections of OLP and OLR thereby aiding a means of distinguishing these lesions. Materials and Methods The study group involved 21 cases of oral lichen planus, 21 cases of oral lichenoid reactions, and 10 control specimens of normal buccal mucosa. All the cases were stained with Toluidine Blue and routine haematoxylin and eosin and the mast cells were quantified. Statistical Analysis Used The results were analyzed using the Kruskal–Wallis test and an intergroup analysis was performed using Mann–Whitney U test. Conclusion The number of mast cells showed an increased value in oral lichen planus when compared to oral lichenoid reaction and thus an estimation of mast cells count could aid in distinguishing OLP from OLR histopathologically.

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“…According to Shirasuna et al [8], Dudhia et al [5], and several other studies [6, 9–11]: dysplasia is a possible feature of OLR and consequently OLRs might be liable to malignant transformation. On the other hand, OLP pre-malignancy is debatable [12–15].…”

Section: Discussionmentioning

confidence: 99%

“…When the previously mentioned clinical and histological features are present in a unilateral distribution in the oral cavity, OLL is the most probable diagnosis. Furthermore, the presence of dysplastic changes on the histological examination favors the diagnosis of OLL [5].…”

Section: Introductionmentioning

confidence: 99%

Hawley retainer and lichenoid reaction: a rare case report

Elhadad

Gaweesh

2019

BMC Oral Health

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BackgroundOral lichenoid reaction (OLR) is a type IV cell-mediated immune response in the oral cavity. There is an established relationship between various dental materials and OLR, but few cases reports reported the occurrence of a lichenoid reaction in association with the use of a Hawley retainer.Case presentationA female patient (twenty years of age) has been complaining of a reddish painful area on the tongue, which started one year ago and has been increasing in size over time. The patient completed orthodontic treatment two years ago and has been using a Hawley retainer for orthodontic retention since then. After performing histological analysis and patch test, the lesion was diagnosed as a lichenoid reaction to the Hawley retainer. Topical corticosteroids were prescribed, and the patient was asked to stop using the retainer and followed for six months.ConclusionsIt is difficult to diagnose lichenoid lesions and even more challenging to differentiate between OLP and OLR, therefore it is essential to do a full intraoral and extraoral examination. OLL can occur in association with Hawley retainer, which we believe could be because it is made of an acrylic based material. Generally, OLL resolves after removal of the cause.

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Oral lichen planus to oral lichenoid lesions: Evolution or revolution

Cited by 26 publications

References 28 publications

DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa

DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa

Role of Mast Cells in Oral Lichen Planus and Oral Lichenoid Reactions

Hawley retainer and lichenoid reaction: a rare case report

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