Oral lichenoid dysplasia: A clinicopathologic analysis

Lovas, John G.L.; Harsanyi, B.B.; ElGeneidy, Ahmed K.

doi:10.1016/0030-4220(89)90115-1

Cited by 41 publications

(19 citation statements)

References 32 publications

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“…Although OLP is considered a premalignant lesion by the World Health Organization (see review in Holmstrup, 1992), it is also argued that OLP per se is not precancerous and that only OLP-like lesions demonstrating dysplasia are potentially at risk of developing into cancer (Eisenberg and Krutchkoff, 1992;Krutchkoff & Eisenberg, 1985;Lovas et al, 1989). A recent study from this laboratory has shown that OLP (without dysplasia) lacked the characteristic genetic alter- (Zhang et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…There have been heated debates as to whether OLP per se is precancerous or whether only OLP-like lesions demonstrating epithelial dysplasia are potentially at risk of developing into cancer (Eisenberg and Krutchkoff, 1992;Holmstrup 1992;Krutchkoff and Eisenberg, 1985;Lovas et al, 1989). After retrospective analysis of original photomicrographs from a number of published cases of alleged malignant transformation of OLP, Krutchkoff and Eisenberg concluded that many reported cases of oral carcinomas arising from OLP may have developed from lichenoid lesions with epithelial dysplasia (Eisenberg and Krutchkoff, 1992).…”

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High Frequency of Allelic Loss in Dysplastic Lichenoid Lesions

Zhang

Cheng

et al. 2000

Laboratory Investigation

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SUMMARY:Oral lichen planus (OLP) is a common mucosal condition that is considered premalignant by some, whereas others argue that only lichenoid lesions with epithelial dysplasia are at risk of progressing into oral carcinoma. A recent study from this laboratory used microsatellite analysis to evaluate OLP for loss of heterozygosity (LOH) at loci on three chromosomal arms (3p, 9p, and 17p) (Am J Path 1997;Vol151:Page323-Page327). Loss on these arms is a common event in oral epithelial dysplasia and has been associated with risk of progression of oral leukoplakia to cancer. The data showed that, although dysplastic epithelium demonstrated a high frequency of LOH (40% for mild dysplasia), a significantly lower frequency of LOH was noted in OLP (6%), which is even lower than that in hyperplasia (14%). Such results do not support OLP as a lesion at risk for malignant transformation. As a second step of the research, we determined LOH frequencies in 61 dysplastic lichenoid lesions (mild 35; moderate 19; severe 7) using the same microsatellite markers and compared these results with data obtained from the first study and from 13 normal mucosal specimens. Dysplastic lichenoid lesions showed a high frequency of loss (54% for lichenoid lesions with mild dysplasia), but values did not differ significantly from those observed in dysplasia of similar degree without lichenoid appearance. None of the normal mucosa demonstrated LOH. Epithelial dysplasia is a sign of malignant risk, independent of lichenoid changes. Such results suggest that pathologists should search for dysplasia carefully in lesions that otherwise qualify as OLP and that caution should be used when discounting dysplasia as being merely a reactive condition in lichenoid lesions. (Lab Invest 2000, 80:233-237).

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

High Frequency of Allelic Loss in Dysplastic Lichenoid Lesions

Zhang

Cheng

et al. 2000

Laboratory Investigation

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“…Oral epithelial dysplasias (lichenoid dysplasia) may exhibit a chronic inflammatory cell infiltrate consisting of mostly lymphocytes that resembles the chronic inflammation seen in lichen planus, however has accompanying epithelial cellular alterations consistent with dysplasia as noted in Table 4 36, 37 . Moreover, the plaque variant of lichen planus and PVL may also share similar clinical and microscopic features, leading to a misdiagnosis of lichen planus 32 .…”

Section: Leukoplakiamentioning

confidence: 99%

Epidemiologic Trends in Head and Neck Cancer and Aids in Diagnosis

Vigneswaran¹,

Williams²

2014

Oral and Maxillofacial Surgery Clinics of North America

692

496

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“…Following Krutchkoff et al. 's paper , it has been ascertained that cases of apparent malignant transformation of OLP are likely to represent red and white lesions that were dysplastic from their inception and that they mimic OLP both clinically and histologically . Lichenoid dysplasia, according to Lodi et al.…”

Section: Introductionmentioning

confidence: 99%

Lichenoid dysplasia revisited – evidence from a review of Indian archives

Patil

Rao

Sanketh

et al. 2014

J Oral Pathology Medicine

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The study confirms lichenoid features may be found in OEDs and epithelial dysplasia may be found in OLP/OLL. We reconfirm that these microscopic features may coexist. Our findings require further discussion by a panel of experts to redefine the entity known as 'lichenoid dysplasia'. Future studies should address the concept of lichenoid dysplasia that may assist to resolve any controversies with regard to the malignant potential of OLP.

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Oral lichenoid dysplasia: A clinicopathologic analysis

Cited by 41 publications

References 32 publications

High Frequency of Allelic Loss in Dysplastic Lichenoid Lesions

High Frequency of Allelic Loss in Dysplastic Lichenoid Lesions

Epidemiologic Trends in Head and Neck Cancer and Aids in Diagnosis

Lichenoid dysplasia revisited – evidence from a review of Indian archives

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