Oral Liposomal Iron: A Treatment Proposal for Anemia

doi:10.5005/jp-journals-10065-0019

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Indeed, it is well established that the presence of vitamin C can increase iron absorption, by creating a more acidic environment in the stomach and preventing the oxidization of ferrous iron to ferric iron [ 14 ]. The shortcomings of these supplements, however, concern the high frequency of gastrointestinal side effects, which lead to inadequate treatment adherence, as well as their low bioavailability [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Bioavailability Assessment of an Iron Formulation Using Differentiated Human Intestinal Caco-2 Cells

Fanzaga,

Bollati,

Ranaldi

et al. 2023

Foods

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In recent years, there has been growing interest in exploring alternative and innovative delivery systems to improve the efficacy of iron supplements, satisfying iron needs and lowering side effects. To address this issue, this study aimed at demonstrating the advantages of Ferro Supremo formulation (composed of encapsulated iron, vitamins, and micronutrients), in terms of capacity to improve iron intestinal absorption, in comparison with standard FeSO4. Hence, differentiated Caco-2 cells have been used for assessing the in vitro bioavailability and safety of FS and FeSO4. MTT experiments demonstrated that both FS and FeSO4 are not able to impair the viability of Caco-2 cells. Furthermore, the quantitative and qualitative analysis, conducted by atomic absorption spectrometry and fluorescence determinations, revealed that FS can enter, accumulate in the cytoplasm, and be transported by intestinal cells four times more efficiently than FeSO4. Our findings indicate that this formulation can be considered a valuable and efficiently good choice as food supplements for improving iron deficiency.

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Section: Introductionmentioning

confidence: 99%

Bioavailability Assessment of an Iron Formulation Using Differentiated Human Intestinal Caco-2 Cells

Fanzaga,

Bollati,

Ranaldi

et al. 2023

Foods

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Anemia of chronic diseases

Orlova,

Karseladze

2024

Medicinskij alfavit

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Anemia of chronic diseases is one of the most common diseases and has a significant impact on prognosis and mortality. The article discusses the relevance, pathogenesis, clinical manifestations, laboratory diagnostics, and treatment of anemia of chronic diseases. The treatment of anemia depends on the severity and the disease of which it is a complication. Anemia is considered in oncological diseases, chronic kidney disease, chronic heart failure, cirrhosis of the liver, celiac disease, etc. Therapy aimed at replenishing iron deficiency includes transfusion of erythrocyte mass, erythropoietin stimulants, iron-containing drugs. According to the literature review, information is provided on the peculiarities of managing patients with anemia in various chronic diseases, an overview of the modern approach to ferrotherapy and its complications is given. Information is provided on a new form of oral iron – Sucrosomal iron (SiderAL Forte), which is well tolerated and has high bioavailability. A review of clinical studies confirming the efficacy and safety of oral Sucrosomal iron is presented.

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Oral Liposomal Iron: A Treatment Proposal for Anemia

Cited by 2 publications

References 23 publications

Bioavailability Assessment of an Iron Formulation Using Differentiated Human Intestinal Caco-2 Cells

Bioavailability Assessment of an Iron Formulation Using Differentiated Human Intestinal Caco-2 Cells

Anemia of chronic diseases

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