Oral Malignant Melanoma

Rk, McDaniel; Sk, Das; Rs, Tomsick; Madhavi, A Vijaya

doi:10.7860/jcdr/2015/11699.5490

Cited by 4 publications

(3 citation statements)

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“…Further, an oral melanoma grows rapidly and exhibits ulcerative evolution with bleeding and pain [25]. Several systemic diseases, including Addison’s disease, Peutz–Jeghers syndrome, McCune–Albright syndrome, Cowden syndrome, neurofibromatosis, acquired immunodeficiency syndrome, haemochromatosis, and hyperthyroidism, as well as uncommon conditions such as Nelson’s syndrome, polyostotic fibrous dysplasia syndrome, Laugier–Hunziker syndrome, and the Carney complex, may feature oral melanotic macules [1, 26, 27]. Melanosis associated with these conditions is due to increased levels of melanin within the basal cell layer, attributable to incontinent melanophages in the lamina propria, in the absence of iron deposits and bleeding [3, 28].…”

Section: Discussionmentioning

confidence: 99%

Hyperpigmentation of the hard palate mucosa in a patient with chronic myeloid leukaemia taking imatinib

Bombeccari

Garagiola

Pallotti

et al. 2017

Maxillofac Plast Reconstr Surg

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BackgroundImatinib mesylate is an inhibitor of the tyrosine kinase Bcr–Abl and a first-line treatment for Philadelphia chromosome-positive chronic myeloid leukaemia (CML). Dermatological side effects include superficial oedema, pustular eruption, lichenoid reactions, erythroderma, and skin rash. Depigmentation of the skin and/or mucosa is uncommon, and hyperpigmentation is rare.Case presentationWe present the case of a 63-year-old Caucasian male with widespread hyperpigmentation of the hard palate associated with a 9-year history of imatinib therapy to treat CML. He did not complain of any symptoms. Clinical examination did not reveal any abnormal pigmentation of the skin or other region of the oral mucosa. He did not smoke cigarettes or drink alcohol. His medication regimen was a proton pump inhibitor, a beta-blocker, cardioaspirin, atorvastatin, and imatinib 400 mg/day. Histopathologically, melanin and haemosiderin deposits were evident in the lamina propria. The lesion persisted, with no clinical change, through several follow-ups. We reviewed the literature to explore the possible relationship between oral hyperpigmentation and long-term imatinib mesylate treatment.ConclusionsWe diagnosed oral pigmentation associated with imatinib intake based on the medical history and clinical features of the pigmented macules. Oral pigmentation may have a variety of causes, and differential diagnosis requires nodal analysis. Clinicians should be aware of possible oral mucosal hyperpigmentation in patients taking imatinib mesylate. Such pigmentation is benign and no treatment is needed, but surveillance is advisable.

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Section: Discussionmentioning

confidence: 99%

Hyperpigmentation of the hard palate mucosa in a patient with chronic myeloid leukaemia taking imatinib

Bombeccari

Garagiola

Pallotti

et al. 2017

Maxillofac Plast Reconstr Surg

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“…Malignant transformations of oral nevi are not reported, and there is no evidence to suggest an increased risk of oral melanoma in patients with oral melanocytic nevi . Clinical appearance of oral melanoma is variable and ranges from an asymptomatic brown to black patch with asymmetrical and irregular borders to a rapidly growing mass associated with sinister features such as pain, ulceration, bleeding, and bone destruction, often in the palate …”

Section: Discussionmentioning

confidence: 99%

Prevalence and clinical features of pigmented oral lesions

et al. 2015

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“…In cases where the dentist needs to establish a person's identity, an orthodontist can sometimes be very helpful [2].…”

Section: Introductionmentioning

confidence: 99%

The use of X-ray spectrometry in forensic expertise. Dental alloy control

Bunget¹,

Bîcă²,

Bărbăcioru³

et al. 2022

AUC Chem

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The analysis of dental materials in forensic investigations is very important. Identifying the victims of accidents or attacks sometimes requires the analysis of their dentures. In this paper, X-ray spectrometry was used as a method to determine the chemical composition of a dental material. In this case, it was established that it was a dental alloy (Cr-Ni-Mo) with a percentage composition of 23.58% Cr, 64.32% Ni and 10.82% Mo.

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Oral Malignant Melanoma

Cited by 4 publications

References 0 publications

Hyperpigmentation of the hard palate mucosa in a patient with chronic myeloid leukaemia taking imatinib

Hyperpigmentation of the hard palate mucosa in a patient with chronic myeloid leukaemia taking imatinib

Prevalence and clinical features of pigmented oral lesions

The use of X-ray spectrometry in forensic expertise. Dental alloy control

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