Oral manifestation in inflammatory bowel disease: A review

Lankarani, Kamran Bagheri; Sivandzadeh, Gholam Reza; Hassanpour, Shima

doi:10.3748/wjg.v19.i46.8571

Cited by 176 publications

(165 citation statements)

References 84 publications

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“…Etiologia nieswoistych zapaleń jelit nie jest w pełni wyjaśniona, ale przyjmuje się wieloprzyczynowość z udziałem czynników immunologicznych, genetycznych i środowisko-wych. Zapadalność na te choroby zależy od róż-nych czynników (genetycznych, środowiskowych, rasowych, etnicznych, wieku, płci, miejsca zamieszkania w aspekcie geograficznym) i wciąż się zwiększa [1]. Około 25-30% wszystkich nowych przypadków nieswoistych zapaleń jelit występuje u osób do 20. roku życia [2,3].…”

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“…stwierdza się co najmniej jeden z pozajelitowych objawów choroby. Mogą one wyprzedzać wystąpienie dolegliwości ze strony przewodu pokarmowego lub pojawiać się podczas trwania choroby [1]. Objawy chorobowe nieswoistego zapalenia jelit mogą być poprzedzone pojawieniem się zmian w jamie ustnej, które częściej występują w chorobie Leśniowskiego-Crohna w porównaniu z colitis ulcerosa, a także częściej u dzieci niż dorosłych i chorych płci męskiej [1].…”

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Oral Cavity Condition and Selected Salivary Parameters in Children and Adolescents Suffering from Inflammatory Bowel Diseases

Kłaniecka¹,

Kaczmarek²

2016

Dent. Med. Probl.

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A -koncepcja i projekt badania, B -gromadzenie i/lub zestawianie danych, C -analiza i interpretacja danych, D -napisanie artykułu, E -krytyczne zrecenzowanie artykułu, F -zatwierdzenie ostatecznej wersji artykułu StreszczenieWprowadzenie. Wrzodziejące zapalenie jelita grubego i choroba Leśniowskiego-Crohna należą do grupy nieswoistych zapaleń jelita. Etiologia tych chorób nie jest w pełni wyjaśniona, jednak przyjmuje się, że jest ona wieloprzyczynowa. Niewiele jest prac oceniających stan jamy ustnej i parametry śliny w przebiegu tych chorób. Cel pracy. Ocena stanu zdrowia jamy ustnej i wybranych parametrów śliny u dzieci chorych na nieswoiste zapalenie jelit. Materiał i metody. Zbadano 102 dzieci w wieku 3,5-18 lat, w tym 52 chorych na nieswoiste zapalenie jelit i 50 zdrowych. Oceniono intensywność próchnicy (puw/z, PUW/Z), stan przyzębia (m-SBI) i występowanie zmian patologicznych na błonie śluzowej. W niestymulowanej ślinie mieszanej oznaczano pH, pojemność buforową, dwuwęglany, białko całkowite, α-amylazę, kwas sjalowy (całkowity, wolny i związany), fosforany nieorganiczne i magnez oraz szybkość wydzielania śliny. Wyniki. U chorych w porównaniu z osobami zdrowymi stwierdzono większą liczbę zębów objętych próchnicą, gorszy stan przyzębia, a u 22% chorych występowanie zmian patologicznych na błonie śluzowej. W ślinie chorych zaobserwowano niższe poziomy pH, pojemności buforowej, a większe białka oraz zbliżone fosforanów i magnezu oraz sekrecji śliny. Wnioski. U chorych częściej występowały nieswoiste zmiany błony śluzowej jamy ustnej i intensywniejsze zapalenie dziąseł, niższe poziomy pH, pojemności buforowej i α-amylazy, ale większe stężenie białka (Dent. Med. Probl. 2016, 53, 2, 210-215).Słowa kluczowe: stan jamy ustnej, nieswoiste zapalenie jelit, składniki śliny. AbstractBackground. Inflammatory bowel disease includes ulcerative colitis and Crohn's disease whose etiology is not fully elucidated, but supposed to be multifactorial. There are only few papers regarding oral condition and salivary components in the course of inflammatory bowel disease. Objectives. The aim of the study was to evaluate the condition of oral and selected salivary parameters in pediatric patients suffering from inflammatory bowel disease. Material and Methods. The authors examined 102 subjects aged 3.5-18 years, 52 patients and 50 healthy individuals. The authors examined caries (dmf/t, DMF/T), periodontal condition (m-SBI), and the occurrence of pathological oral mucosa lesions. Buffering capacity, bicarbonates, total protein, α-amylase, sialic acid (total, free and bonded), inorganic phosphates, and magnesium and salivary flow were assessed in the unstimulated mixed saliva pH. Results. In patients, compared to healthy individuals, the authors reported a worse periodontal condition, and in 22% of patients the occurrence of mucosa lesions. Caries severity was not higher among patients. In the saliva of patients, compared to healthy individuals, the authors found lower levels of pH, buffering capacity, a higher concentration of total...

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Oral Cavity Condition and Selected Salivary Parameters in Children and Adolescents Suffering from Inflammatory Bowel Diseases

Kłaniecka¹,

Kaczmarek²

2016

Dent. Med. Probl.

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“…Recurrent aphthous stomatitis may be associated with inflammatory bowel disease and celiac disease 27. The pathogenesis of RAS remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Recurrent aphthous stomatitis is usually found in patients with Crohn's disease, systemic lupus erythematosus, and Behçet's disease (BD) 27, 44, 45. The underlying cause of RAS is unknown.…”

Section: Discussionmentioning

confidence: 99%

Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case‐control frequency‐matched study

et al. 2018

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BackgroundRecurrent aphthous stomatitis (RAS) is considered a prophase symptom in patients with specific cancers. This study assessed the association between RAS and subsequent onset of cancer based on a nationwide population‐based database in Taiwan.Materials and MethodsWe selected study participants from the National Health Insurance Research Database from January 2000 to December 2008. Patients in the non‐RAS cohort were matched to case study patients at a 1:1 ratio through frequency matching. All participants were followed up for at least 5 years, and those who received cancer diagnoses during follow‐up were identified.ResultsAmong 52 307 patients with and 52 304 patients without RAS, the combined hazard ratio (HR) of all subsequent cancer cases was 1.3 (95% confidence interval [CI]: 1.25‐1.35, P = 0). RAS diagnosis was associated with risk for cancers of the head and neck (aHR = 2, 95% CI: 1.8‐2.3), colon (aHR = 1.2, 95% CI: 1.1‐1.4), liver (aHR = 1.1, 95% CI: 1‐1.3), pancreas (aHR = 1.4, 95% CI: 1.1‐1.7), skin (aHR = 1.4, 95% CI: 1.2‐1.7), breast (aHR = 1.2, 95% CI: 1.1‐1.4), and prostate (aHR = 1.5, 95% CI: 1.3‐1.8), as well as hematologic cancers (aHR = 1.6, 95% CI: 1.3‐1.9). A higher risk was observed for male patients (aHR = 1.35, 95% CI: 1.28‐1.42) than for female patients (aHR = 1.25, 95% CI: 1.18‐1.31) with RAS.Conclusions RAS was associated with specific cancers. Susceptible RAS patients should be screened for specific cancers.

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“…40 One of the reasons why it is important to be aware of the signs and symptoms of CD is due to the hypothesis that oral inflammation may precede intestinal manifestation of disease. 41 In a tertiary centre case-control study conducted in Portugal, consisting of 113 patients with previously diagnosed IBD and 58 healthy controls, there was a significantly increased prevalence of oral symptoms when compared with the control that did not have IBD (54.9% vs. 24.3%, P = 0.011). 42 Oral symptoms were also present in a greater proportion within the active phase cohort than in the remission cohort (70.6% vs. 52.1%, P = 0.001).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory bowel disease and oral health

Chandan

Thomas

2017

BDJ Team

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Risk factors involved in IBDIBD is thought to result from inappropriate and ongoing activation of the mucosal immune system facilitated by defects in both the intestinal epithelium and mucosal immune system. 5 There are both genetic and environmental factors implicated in the aetiology of IBD. 6 Although traditionally associated with the developed world, recent epidemiological studies suggest an increasing incidence in rapidly developing countries, especially in South-East Asia. 7 In addition, the increased risk of IBD in the immigrant populations in the West suggests environment has a role in the development of IBD. 8 Genetic Detailed genetic mapping has identified specific genetic changes on chromosome 16 carried in families which appear linked to CD, however no significant changes have been mapped as of yet to UC. 9,10 Specifically, variants of the NOD2 gene provide the strongest association with susceptibility to CD. NOD2 plays a key role in regulating the gut mucosal barrier involving, specifically, the microbiota, as well as the related response by the innate and adaptive immune system. The IBDchip European Project showed NOD2 has been implicated in ileal location colitis with stenosing and penetrating disease behaviour. 11 A genome wide association study has also identified a strong link between the IL23R gene and CD. 12 The gene in particular codes for interleukin 23 that plays a role in regulating innate immunity within the intestine. 13 Cigarette smoking Unusually, cigarette smoking is associated with decreased rates of incidence of UC and has been associated with protective features to prevent further flare-ups of the condition 14-19 such as relapses, 20 ©SEBASTIAN KAULITZKI/Science Photo Library/Getty J. S. Chandan 1 and T. Thomas 1 summarise the treatments for inflammatory bowel disease (IBD) and how anti-inflammatory medications can have side effects that affect the oral cavity.

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Oral manifestation in inflammatory bowel disease: A review

Cited by 176 publications

References 84 publications

Oral Cavity Condition and Selected Salivary Parameters in Children and Adolescents Suffering from Inflammatory Bowel Diseases

Oral Cavity Condition and Selected Salivary Parameters in Children and Adolescents Suffering from Inflammatory Bowel Diseases

Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case‐control frequency‐matched study

Inflammatory bowel disease and oral health

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