Oral manifestation of the monkeypox virus: a systematic review and meta-analysis

P, Aravind Gandhi; Patro, Sourabha Kumar; Sandeep, Mokanpally; Satapathy, Prakasini; Shamim, Muhammad Aaqib; Kumar, Veerendra; Aggarwal, Arun Kumar; Padhi, Bijaya Kumar; Sah, Ranjit

doi:10.1016/j.eclinm.2022.101817

Cited by 21 publications

(15 citation statements)

References 36 publications

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“…Studies conducted among African mpox patients had a significantly higher prevalence of ophthalmic lesions than their European counterparts. A similar geographical variation in the prevalence of rash (the most common symptom of mpox) and oral lesions was also noted from previous reviews [ 7 , 11 ]. This is also closely related to the endemicity of mpox, as all African studies included were from mpox-endemic countries, and all studies outside Africa were from non-endemic countries.…”

Section: Discussionsupporting

confidence: 81%

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Ophthalmic Manifestations of the Monkeypox Virus: A Systematic Review and Meta-Analysis

Gupta

Padhi

et al. 2023

Pathogens

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Background: The accurate estimation of the prevalence of mpox-induced ophthalmic lesions will enable health departments to allocate resources more effectively during the ongoing mpox pandemic. The aim of this meta-analysis was to estimate the global prevalence of ophthalmic manifestations in mpox patients. Methods: A systematic search was carried out in seven databases—Pub Med, Scopus, Web of Science, EMBASE, ProQuest, EBSCOHost, and Cochrane—for studies published on or before 12 December 2022. The pooled prevalence of ophthalmic manifestations was estimated by the random effects model. Risk of bias assessment of the studies and sub-group analysis to explain heterogeneity were undertaken. Results: Overall, 12 studies were included, with 3239 confirmed mpox cases, among which 755 patients reported ophthalmic manifestations. The pooled prevalence of ophthalmic manifestations was 9% (95% confidence interval (CI), 3–24). Studies from Europe reported a very low prevalence of ocular manifestations of 0.98% (95% CI 0.14–2.31), compared to studies from Africa with a substantially higher prevalence of 27.22% (95% CI 13.69–43.26). Conclusions: A wide variation in the prevalence of ocular manifestations among mpox patients was observed globally. Healthcare workers involved in mpox-endemic African countries should be aware of ocular manifestations for early detection and management.

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Section: Discussionsupporting

confidence: 81%

“…This transition is under study during the ongoing multi-country outbreak [ 7 ]. Atypical manifestations involving other systems, such as the oral, neurological, and respiratory systems, have been reported among patients with mpox [ 7 , 11 ]. Similarly, ocular signs and symptoms have also been reported among mpox patients.…”

Section: Introductionmentioning

confidence: 99%

Ophthalmic Manifestations of the Monkeypox Virus: A Systematic Review and Meta-Analysis

Gupta

Padhi

et al. 2023

Pathogens

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“…Mpox is a rare viral disease that belongs to the same family as smallpox and is primarily found in central and West African countries. 2 While it can cause a wide range of symptoms, including skin lesions, MPXV-oral lesions are present in 37%–41% of patients 5,13 as papules, vesicles, pustules, and ulcers. 3,4 An early MPXV diagnosis helps to limit the infection spreading and to establish appropriate medical and dental treatment.…”

Section: Discussionmentioning

confidence: 99%

“…2 Several recent reports on MPXV-oral lesions have been published. [3][4][5][6][7][8][9][10] Two scoping reviews 3,4 and a meta-analysis 5 have provided valuable insights into the presence and clinical characteristics of MPXV-oral lesions. However, to our knowledge, information regarding the histological and ultrastructural MPVX findings in the oral mucosa is not available.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological and molecular approaches to the diagnosis of oral lesions in Mpox: Case report

Ramírez-Amador,

Figueroa-Ramos,

Valencia-Mayoral

et al. 2023

Int J STD AIDS

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Mpox virus infection (MPXV) has recently been recognized as a public health emergency by the World Health Organization. While several studies have described the clinical characteristics of MPXV-oral lesions, there remains a dearth of information regarding the histological and ultrastructural oral findings. A 24-year-old HIV-positive man presented with a shallow ulcer, covered by a fibrinoid membrane, and surrounded by an erythematous halo in the hard and soft palate. The clinical appearance of the lesion raised suspicion of a viral infection; thus, the diagnosis was based on histological and electronic microscopy findings and confirmed by RT-PCR testing in the skin specimen. This case report aims to offer comprehensive insights into the clinical, histopathological, and ultrastructural features of oral lesions caused by MPXV in an individual with HIV. This report provides valuable information about the characteristics of MPXV infection in the oral mucosa, particularly in people living with HIV.

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“…In many cases, oral lesions may precede skin rash, fever, lymphadenopathy, and other associated major symptoms [ 2 , 3 ]. The few case reports currently in the literature dedicated to oral clinical manifestations report mainly erosive lesions at the lingual level, erosive-erythematous crusted at the labial level [ 4 ]. The lingual lesions described involve the part adjacent to the lingual tip in correspondence of the midline, both at the dorsal level and at the ventral level.…”

Section: To the Editors Of The Pan African Medical Journalmentioning

confidence: 99%

Oral manifestations of monkeypox and potential tools for their management

Casu¹,

Murgia²,

Orrù³

2023

Pan Afr Med J

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Oral manifestation of the monkeypox virus: a systematic review and meta-analysis

Cited by 21 publications

References 36 publications

Ophthalmic Manifestations of the Monkeypox Virus: A Systematic Review and Meta-Analysis

Ophthalmic Manifestations of the Monkeypox Virus: A Systematic Review and Meta-Analysis

Clinicopathological and molecular approaches to the diagnosis of oral lesions in Mpox: Case report

Oral manifestations of monkeypox and potential tools for their management

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