Oral manifestations in SARS-CoV-2 infection

Tüter, Gülay; Yerebakan, M; Çelik, Berrin; Kara, G

doi:10.4317/medoral.25259

Cited by 12 publications

(29 citation statements)

References 30 publications

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“…Italy accounted for the most articles, with 14 studies [ 16 , 19 , 20 , 22 , 23 , 28 , 29 , 36 , 37 , 58 , 66 , 72 , 81 , 86 ]. This was followed by India with 8 studies [ 17 , 33 , 44 , 45 , 50 , 55 , 80 , 83 ], United States with 7 studies [ 21 , 25 ,, 30 , 31 , 54 , 62 , 79 ], Brazil with 7 studies [ 9 , 47 , 49 , 52 , 56 , 75 , 77 ], and both Egypt and Turkey with 5 studies each [ 34 , 38 , 41 , 68 , 71 ] and [ 26 , 39 , 42 , 48 , 64 ], respectively. Iran [ 5 , 53 , 59 , 60 ], Iraq [ 12 , 43 , ...…”

Section: Resultsmentioning

confidence: 99%

“…Most of the 79 studies were cross-sectional studies ( n =41) [ 5 , 12 − 26 , 29 − 31 , 33 , 34 , 37 − 46 , 48 − 51 , 53 − 55 , 84 − 86 ] followed by case reports ( n =20) [ 9 , 61 − 75 , 78 − 81 ], case series ( n =11) [ 6 , 8 , 56 − 60 , 76 , 77 , 82 , 83 ], retrospective studies ( n =6) [ 27 , 28 , 35 , 36 , 47 , 52 ], and case-control studies ( n =1) [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

“…Xerostomia was noted in 22 cross-sectional studies [ 13 , 15 , 22 , 28 , 34 , 37 , 38 , 40 − 42 , 44 − 46 , 48 , 50 − 55 , 84 , 85 ] and 2 case reports [ 60 , 78 ].…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Estimating the prevalence of oral manifestations in COVID-19 patients: a systematic review

Gupta,

Shrivastav,

Agrawal

et al. 2023

PHRP

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Objectives: Patients with coronavirus disease 2019 (COVID-19) present with a variety of oral manifestations. Therefore, we conducted a systematic review to estimate the prevalence of oral lesions among COVID-19 patients. Methods: An extensive literature search of several electronic bibliographic databases (PubMed, Scopus, Science Direct, Litcovid) was conducted to retrieve all articles published in the English language from January 1, 2020 to March 31, 2023 that reported the prevalence of oral manifestations among COVID-19 patients. A meta-analysis of pooled prevalence was performed using Jamovi ver. 2.3 (2022). The I2 and Q statistics were used to assess heterogeneity between studies, and p-values <0.01 were considered statistically significant. Results: In total, 79 studies with data from 13,252 patients were included. The articles were predominantly published in 2020 (n=33), and Italy was the most common country (n=14). Most of the affected patients more than 50 years old and women (56.6%). The most common sites of involvement were the tongue (n=65), followed by the oral mucosa (n=37) and lips (n=19). High heterogeneity was found between studies. The most common oral manifestation was taste alteration, followed by xerostomia and ulceration, showing pooled prevalence rates of 48%, 35%, and 21%, respectively. Conclusion: COVID-19 patients show various oral manifestations that may help clinicians identify the disease promptly. Recognition of the signs and symptoms of COVID-19 is critical for an early diagnosis and better prognosis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Estimating the prevalence of oral manifestations in COVID-19 patients: a systematic review

Gupta,

Shrivastav,

Agrawal

et al. 2023

PHRP

View full text Add to dashboard Cite

show abstract

“…Martín Carreras-Presas et al reported different types of oral mucosal lesions (ulcer, vesicle, bulla, and desquamative gingivitis) in patients with COVID-19 [ 21 ]. Tuter et al showed that dry mouth is the most common and oral ulcers and tongue lesions are the second common oral manifestation in COVID-19 patients [ 13 ]. Cuevas-Gonzalez et al stated that the most common main oral manifestations related to SARS-CoV-2 were dysgeusia, dry mouth, burning mouth, ulcerative lesions, and Candida Albicans infections in their systematic review including a total of 18 studies [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Oral Mucosal Manifestations Associated With PCR Positivity in Patients With COVID-19

Metin,

Yıldız,

Turan

2024

Dermatol Pract Concept

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Introduction: To date various oral manifestations in patients with coronavirus disease 2019 (COVID-19) have been reported. Objectives: In the present study, we investigated the relationship between Polymerase Chain Reaction (PCR) positivity and oral signs in patients with suspected COVID-19. Methods: A total of 383 patients who presented to the emergency department for the first time with any symptoms associated with COVID-19 were included in the study. Oral examinations were performed and the findings, PCR status, and thorax computerized tomography (CT) reports were recorded. Results: Oral mucosa was involved in 246 (64.2%) patients. 175 (78,4%) of patients with COVID-19 confirmed the diagnosis with PCR test or CT results had oral manifestation. Dry mouth, microvesicles on the tonsils or pharynx, and petechiae in the oropharynx were significantly higher in patients with positive PCR tests (P = 0.001, P < 0.001, P < 0.001, respectively). The ratio of intact oral mucosa was statistically significantly higher in patients with negative PCR tests compared to those with positive PCR tests (P < 0.001). Microvesicles on the tonsils or pharynx were most associated with PCR positivity in patients without lung involvement (P < 0.001). Dry mouth, erythema of the tonsils and pharynx, petechiae in the oropharynx, and primary/secondary herpes infection are more related to PCR positivity in patients without lung involvement (P < 0.05). Lung involvement in patients with PCR positivity is related to only cheilitis (P = 0.034). Conclusions: Our study revealed that especially microvesicles, petechiae, erythema on the tonsils or pharynx, and some other oral lesions such as dry mouth, oral aphthae, and primary/secondary herpes infection are associated with PCR positivity.

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“…The most common clinical symptoms include fever, tiredness, headache, sore throat, dyspnea, myalgia, dry cough, abdominal pain, vomiting, and diarrhea. In addition to these primary manifestations, some oral symptoms have also been reported, such as xerostomia, aphthous-like lesions, ulcers, tongue depapillation, necrotizing gingivitis, and taste disorders, including the loss of taste and salivary gland infections ( 2 - 4 ).…”

Section: Introductionmentioning

confidence: 99%

Oral ulcer in SARS-CoV-2 infection: a case report

Rapp,

Gémar,

Lacoste-Ferré

2024

AME Case Rep

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Background The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the end of 2019 caused the global pandemic. Oral and dermatological manifestations of coronavirus disease 2019 (COVID-19) such as xerostomia, aphthous-like lesions, ulcers, tongue depapillation, necrotizing gingivitis, and taste disorders, including the loss of taste and salivary gland infections are being reported. This study aims to describe a case of oral ulcers following COVID-19 infection. Case Description We present the case of a 95-year-old male patient hospitalized in follow-up care and rehabilitation unit, of Minimes Geriatric Clinic, Toulouse, France. He had an alteration in his general health in the context of COVID-19 infection detected by reverse transcription polymerase chain reaction (RT-PCR). Six days after the admission, the patient complained of a strong burning sensation of the mouth, especially on the tongue and the lips’ mucosa. Intraoral examination revealed painful erosive areas on the lateral edges of the tongue and the mucous side of the lower lip. The proposed treatment to reduce the burning sensation was based on general analgesics (morphine sulfate), mouthwash with sodium bicarbonate, the application of a lidocaine-based oral anesthetic and healing gel and a comfort-oriented diet. Thirteen days later, the patient reported a gradual improvement. Conclusions A diverse range of oral manifestations has been observed in patients with a history of COVID-19 infection. These oral ulcers significantly impact the quality of life of the individual, causing intense pain, stress, and difficulties in eating, with repercussions on nutritional status, especially in older individuals. Our case underscores the importance of oral examinations and the role of dentists in the management of patients with SARS-CoV-2.

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Oral manifestations in SARS-CoV-2 infection

Cited by 12 publications

References 30 publications

Estimating the prevalence of oral manifestations in COVID-19 patients: a systematic review

Estimating the prevalence of oral manifestations in COVID-19 patients: a systematic review

Oral Mucosal Manifestations Associated With PCR Positivity in Patients With COVID-19

Oral ulcer in SARS-CoV-2 infection: a case report

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