Oral manifestations leading to the diagnosis of acute lymphoblastic leukemia in a young girl

Silva, B A; Siqueira, Carlos Rodrigo Barros de; Castro, Paulo Henrique Souza; Araújo, Sabrina S.; Volpato, Luiz Evaristo Ricci

doi:10.4103/0970-4388.100003

Cited by 14 publications

(2 citation statements)

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“…15 Hou et al, who examined patients with AL by dividing them into two types (ALL and AML), reported head and neck LAP in patients with ALL more than with AML (71.4% > 45%). 9 There are many case reports in the literature that reported submandibular LAP 6,11,[19][20][21][22][23] and/or cervical LAP 6,11,18,[24][25][26][27] in the head and neck region in AL patients. The relatively lower frequency of LAP in this study compared to previous studies may be related to the inclusion of only newly diagnosed AL patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of oral manifestations and head and neck lymphadenopathy in newly diagnosed acute leukemia patients

Pamukcu,

Dal,

Yaman

et al. 2023

Special Care in Dentistry

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ObjectivesTo determine the frequency of head and neck lymphadenopathy (LAP) and intraoral findings (non‐dental/dental) in patients with newly diagnosed acute leukemia (AL).Subjects and methodsTwenty‐eight (52.8%) females and 25 (47.2%) males in a total of 53 patients with newly diagnosed AL with a mean age of 46 years were included in the study. Personal information, the type of AL (AML [acute myelogenous leukemia]/ALL [acute lymphocytic leukemia]), and hematological findings (anemia, neutropenia, and thrombocytopenia) were obtained from medical records. One of two calibrated oral diagnosis and maxillofacial radiology specialists performed extraoral (head and neck LAPs) and intraoral (non‐dental and dental) clinical examinations. The Chi‐square (χ2) test was used to evaluate categorical variables.ResultsLAP was observed in 22.6% and intraoral findings in 30.2% of the patients. LAP was most commonly observed in the neck and none in the parotid glands. The most intraoral findings were gingival/mucosal bleeding and oral petechiae/ecchymosis. While there was no statistical difference between AML and ALL patients in terms of LAP (p > .05), intraoral findings were observed more in patients with AML (p < .05). Only two (3.8%) patients had dental findings. With a slight difference, intraoral findings were more with thrombocytopenia and LAP with neutropenia.ConclusionIn AL, especially non‐dental intraoral findings are common. The fact that dentists working in the oral cavity are often the first specialists to encounter the oral manifestations of AL imposes an important role in early diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

Evaluation of oral manifestations and head and neck lymphadenopathy in newly diagnosed acute leukemia patients

Pamukcu,

Dal,

Yaman

et al. 2023

Special Care in Dentistry

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“…There are only a few studies about oral hygiene and periodontal status in adult patients with leukemia during chemotherapy. The literature mainly presents information on the oral health of children [ 16 , 17 , 18 , 19 , 20 , 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Oral Hygiene Considerations in Adult Patients with Leukemia during a Cycle of Chemotherapy

Ptasiewicz

Maksymiuk

Chałas

2022

IJERPH

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The oral cavity is the place where the first symptoms of systemic diseases may appear. Leukemia is the malignancy of the hematopoietic system in which abnormal leukocytes are produced in the bone marrow and these cells spread to the peripheral blood. It is classified clinically on the basis of the duration and nature of the disease (acute or chronic), the type of cell involved (myeloid, lymphoid, or monocytes), and a rise in the number of abnormal cells in the blood. The study aimed to assess and compare the oral hygiene and periodontium status based on the indices in leukemic patients before and after one cycle of chemotherapy and whether the therapy had an impact on the change of these parameters. Dental indices used in clinical diagnostics were calculated: API (approximal plaque index), SBI (sulcus bleeding index), and CPI (community periodontal index). The research project was conducted at the Clinic of Hematooncology and Bone Marrow Transplantation of the Independent Public Clinical Hospital No. 1 in Lublin. The target population consisted of 102 adults with leukemia who were over 18 years of age. The time since diagnosis of the disease ranged from 1 to 10 years. The data were evaluated in the Statistica 12 software with the respective tests. In the majority of patients, both before and after chemotherapy, improper oral hygiene and severe generalized periodontitis were confirmed. The cycle of chemotherapy that was used did not correlate with the change of patients’ oral hygiene and periodontium state. Unsatisfactory oral hygiene and periodontal health has to be addressed with urgent dental treatment to avoid systemic complications in leukemic patients.

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Oral manifestations in pediatric patients with leukemia

Bastos Silveira,

Di Carvalho Melo,

Amorim dos Santos

et al. 2024

The Journal of the American Dental Association

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Oral manifestations leading to the diagnosis of acute lymphoblastic leukemia in a young girl

Abstract: dentists must be able to clearly recognize oral physiological characteristics, and, when identifying changes of normalcy, to fully investigate it requesting additional tests or referring the patient to specialized professionals.

Cited by 14 publications

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Evaluation of oral manifestations and head and neck lymphadenopathy in newly diagnosed acute leukemia patients

Evaluation of oral manifestations and head and neck lymphadenopathy in newly diagnosed acute leukemia patients

Oral Hygiene Considerations in Adult Patients with Leukemia during a Cycle of Chemotherapy

Oral manifestations in pediatric patients with leukemia

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