Oral Manifestations of Crohn's Disease: Studies in the Pathogenesis

Basu, M. K.

doi:10.1177/003591577606901019

Cited by 12 publications

(10 citation statements)

References 9 publications

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“…As parotid IgA secretion is reduced with increasing activity of bowel disease, the suggestion has been made that local immunological mechanisms may be responsible for the development of the oral lesions. It has been suggested that in these patients, biological mediators are released by sensitised lymphocytes when E. coli antigens and related Klebsiella antigens from the mouth enter the oral tissues, with consequent development of inflammatory lesions …”

Section: Pathogenesis Of Oral Manifestations In Ibdmentioning

confidence: 99%

“…It has been suggested that in these patients, biological mediators are released by sensitised lymphocytes when E. coli antigens and related Klebsiella antigens from the mouth enter the oral tissues, with consequent development of inflammatory lesions. 135,136 In patients with CD, salivary IgA antibody responses to Saccharomyces cerevisiae, Candida albicans and Streptococcus mutans have been demonstrated. Production of salivary IgA was found reduced in active CD.…”

Section: Pathogenesis Of Oral Manifestations In Ibdmentioning

confidence: 99%

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Review article: non‐malignant oral manifestations in inflammatory bowel diseases

Κατσάνος

Torres

Roda

et al. 2015

Aliment Pharmacol Ther

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Summary Background Patients with inflammatory bowel diseases (IBD) may present with lesions in their oral cavity. Lesions may be associated with the disease itself representing an extraintestinal manifestation, with nutritional deficiencies or with complications from therapy. Aim To review and describe the spectrum of oral nonmalignant manifestations in patients with inflammatory bowel diseases [ulcerative colitis (UC), Crohn's disease (CD)] and to critically review all relevant data. Methods A literature search using the terms and variants of all nonmalignant oral manifestations of inflammatory bowel diseases (UC, CD) was performed in November 2014 within Pubmed, Embase and Scopus and restricted to human studies. Results Oral lesions in IBD can be divided into three categories: (i) lesions highly specific for IBD, (ii) lesions highly suspicious of IBD and (iii) nonspecific lesions. Oral lesions are more common in CD compared to UC, and more prevalent in children. In adult CD patients, the prevalence rate of oral lesions is higher in CD patients with proximal gastrointestinal tract and/or perianal involvement, and estimated to range between 20% and 50%. Oral lesions can also occur in UC, with aphthous ulcers being the most frequent type. Oral manifestations in paediatric UC may be present in up to one‐third of patients and are usually nonspecific. Conclusions Oral manifestations in IBD can be a diagnostic challenge. Treatment generally involves managing the underlying intestinal disease. In cases presenting with local disabling symptoms and impaired quality of life, local and systemic medical therapy must be considered and/or oral surgery may be required.

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Section: Pathogenesis Of Oral Manifestations In Ibdmentioning

confidence: 99%

Section: Pathogenesis Of Oral Manifestations In Ibdmentioning

confidence: 99%

Review article: non‐malignant oral manifestations in inflammatory bowel diseases

Κατσάνος

Torres

Roda

et al. 2015

Aliment Pharmacol Ther

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“…These may include affection of the joints, eyes, skin, mouth, liver and pancreas (Bevenius 1988, Veloso et al 1996, Jiang et al 2006 (Table 1). The prevalence of oral lesions in patients with CD ranges between 6% and 20% (Basu 1976, Greenstein et al 1976, Rankin 1990, Plauth et al 1991. Oral manifestations can also be caused by IBD-induced malabsorption.…”

mentioning

confidence: 99%

What can we learn about biofilm/host interactions from the study of inflammatory bowel disease

Indriolo

Greco

Ravelli

et al. 2011

J Clinic Periodontology

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Objectives: The aim of this review was to evaluate possible common pathogenic pathways and risk factors in inflammatory bowel disease (IBD) and periodontitis. Materials and Methods: A MEDLINE-PubMed research was conducted. Results: The pathogenesis of both diseases is multi-factorial leading to a substantial defect of the mucosal barrier, deregulation of the immune response and chronic inflammation of the mucosa. Environmental factors, particularly bacteria, are key factors in the pathogenesis of both diseases. Genetic predisposition is a key factor in the IBD pathogenesis, while a clear role of genetics in the pathogenesis of periodontitis is still unclear. The immune response in IBD is mediated by T lymphocytes as a consequence of a genetic trait associated with T-cell deregulation. On the other hand, in periodontitis plasma cells and lymphocytes are the predominant cells in the chronic inflammatory lesion, with the presence of B cells being proportionally larger than T cells. Conclusion: IBD and periodontitis share several factors in their aetiology and pathogenesis, although they also have distinct characteristics.

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“…O ral lesions are not uncommon clinical findings in Crohn's disease, and may occur before the onset of gastrointestinal symptoms or during the disease course (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Crohn's disease presenting as cheilitis in young children is rare.…”

Section: Maladie De Crohn Et Chéilitementioning

confidence: 99%

“…In nine of 29 patients, oral and/or facial lesions presented at least four years before the diagnosis of Crohn's disease (9). The oral lesions generally develop when bowel disease is active (10)(11)(12)). An interesting feature in our patient was the persistence of lip swelling after he went into clinical remission of the intestinal symptoms.…”

Section: Brief Communicationmentioning

confidence: 99%

Crohn’s Disease and Cheilitis

Al–Hussaini

Machida

Butzner

2003

Canadian Journal of Gastroenterology

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A five-year-old boy presented to his family physician with painless swelling of both lips. One year later he developed abdominal pain, nonbloody diarrhea, weight loss and joint pains. Colonoscopic examination demonstrated patchy erythema, friability and multiple aph-thous ulcers consistent with the appearance of Crohn's colitis, and treatment with prednisone was initiated. Colonic biopsies displayed a chronic inflammatory cell infiltrate, focal cryptitis and fissure formation. The patient's lip swelling relapsed on multiple occasions when steroids were tapered, despite minimal intestinal symptoms of Crohn's disease. The objective of the present report is to alert physicians to this unusual presentation of Crohn's disease and that cheilitis may run a protracted course.

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Oral Manifestations of Crohn's Disease: Studies in the Pathogenesis

Cited by 12 publications

References 9 publications

Review article: non‐malignant oral manifestations in inflammatory bowel diseases

Review article: non‐malignant oral manifestations in inflammatory bowel diseases

What can we learn about biofilm/host interactions from the study of inflammatory bowel disease

Crohn’s Disease and Cheilitis

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