Oral Manifestations of Cutaneous T Cell Lymphoma

Kasha, Edwin E.; Parker, Colleen M.

doi:10.1111/j.1365-4362.1990.tb02561.x

Cited by 9 publications

(19 citation statements)

References 19 publications

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“…8,9,12,13 The neoplastic cells have similar appearances in both skin and mucosal sites. Epithelial involvement is usually a common feature, with formation of Pautrier microabscesses as the disease progresses.…”

Section: Discussionmentioning

confidence: 96%

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Oral-Cutaneous CD4-Positive T-cell Lymphoma: A Study of Two Patients

May¹,

Jones²,

Medeiros³

et al. 2007

The American Journal of Dermatopathology

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We describe two slowly progressive cases of T-cell lymphoma that involved both acral skin and oral cavity. One patient presented with a tongue nodule, completely responded to chemotherapy and then developed recurrent lymphoma involving tongue and skin a few months later that also responded to therapy. The second patient presented with a skin nodule that spontaneously resolved without therapy, and subsequently recurred in tongue and skin a few years later. In both cases, the neoplasms were composed of atypical lymphoid cells with epidermotropism and were of T-helper cell lineage (CD4+). The initial lesions were also negative for CD30. Identical T-cell receptor gene rearrangements were detected in the initial and recurrent lesions of one case. Although these neoplasms were classified as unspecified peripheral T-cell lymphoma because of the unusual distribution of disease, both cases also had histopathologic features of mycosis fungoides. These cases are strikingly similar, and may represent an unusual clinicopathologic type of T-cell lymphoma that can hone to cutaneous and oral mucosal sites with a slowly progressive natural history.

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Section: Discussionmentioning

confidence: 96%

“…9,[12][13][14] There are rare case reports of mucosal lesions of MF preceding skin involvement, but it is controversial whether these cases represent peripheral T-cell lymphoma or MF. 12 Oral involvement presenting as the inaugural tumor phase of MF has also been reported.…”

Section: Discussionmentioning

confidence: 99%

Oral-Cutaneous CD4-Positive T-cell Lymphoma: A Study of Two Patients

May¹,

Jones²,

Medeiros³

et al. 2007

The American Journal of Dermatopathology

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“…[1][2][3][4][5][6][7] The majority of these cases describe tumors found within the oral cavity. We report a unique case of MF occurring on the nasal mucosa.…”

Section: Mycosis Fungoides Involving the Nasal Mucosamentioning

confidence: 99%

“…This case and the previously reported cases suggest that the association of GCMN and schwannoma represents a previously unrecognized form of neurocristopathy. Because neural crest cells of the trunk may give rise to pigment cells, neuroblasts, and connective tissues, 5 …”

mentioning

confidence: 99%

Mycosis fungoides involving the nasal mucosa

Gruson¹,

Heller²,

Hemmerdinger³

et al. 2007

Journal of the American Academy of Dermatology

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“…Oral involvement in MF [21, 22, 23, 24, 25, 26, 27, 28]is an uncommon (less than 1% of cases) feature and usually is associated with poor prognosis. Clinically the oral lesions are manifested as painful ulcers, nodules or erythematous indurated plaques, leukoplakia-like surface involving with descending frequency the tongue, palate, gingival, buccal mucosa, lips and oropharynx.…”

Section: Commentmentioning

confidence: 99%

Oral Involvement in Lymphomatoid Papulosis

et al. 2005

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Oral involvement in cutaneous CD30+ T-cell lymphoid proliferations is rare and has received little attention in the dermatologic literature. The authors report 2 patients with self-healing, recurrent papulonodular eruptions with the classic clinical, histopathological and immunophenotypic features of lymphomatoid papulosis, which developed two ulcerated papules and an ulcerative nodule on the dorsum of the tongue, respectively. The lesions appeared coincident with a new cutaneous relapse of the disease. Histopathological and immunophenotypic features were similar to those of the cutaneous lesions. All lesions regressed spontaneously after several weeks. Since then, and after follow-up periods of 3 and 7 years, respectively, no evidence of extracutaneous involvement has been detected. Oral involvement in lymphomatoid papulosis is an uncommon event, probably without prognostic significance. Previously reported cases are reviewed. The differential diagnosis of atypical T-cell lymphoid infiltrates observed in the oral mucosa is discussed.

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Oral Manifestations of Cutaneous T Cell Lymphoma

Cited by 9 publications

References 19 publications

Oral-Cutaneous CD4-Positive T-cell Lymphoma: A Study of Two Patients

Oral-Cutaneous CD4-Positive T-cell Lymphoma: A Study of Two Patients

Mycosis fungoides involving the nasal mucosa

Oral Involvement in Lymphomatoid Papulosis

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