Oral manifestations of cyclical neutropenia associated with hypergammaglobulinemia

Telsey, Bernard; Beube, Frank E.; Zegarelli, Edward V.; Kutscher, Austin H.

doi:10.1016/0030-4220(62)90170-6

Cited by 12 publications

(2 citation statements)

References 5 publications

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“…Further sequential section of the same lesion, stained with rhodamine-conjugated goaf IgG against human C. Fluorescence suggests that C is fixed af the positron of A. viscosus -Abs complexes. al. 1962, Wade & Stafford 1963, Gates 1969.…”

Section: Discussionmentioning

confidence: 99%

Identification of bacteria in immunopathological mechanisms of human periodontal diseases

Pekovic

Fillery

1984

J of Periodontal Research

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Serial frozen sections were cut from seventy samples of gingiva of periodontal patients and used for the identification of oral bacteria in immunopathological mechanisms. These mechanisms were identified by sera raised against A. viscosus, A. naeslundii, B. gingivalis, and B. melaninogenicus ss. intermedius; commercial sera against human immunoglobulins and complement; and monoclonal antibodies against T‐cells using a double‐staining immunofluorescence technique. Sections of gingival samples from healthy sites were usually plaque‐free and showed no penetration of bacteria or bacterial antigen or appreciable inflammation. Neither antigenantibody‐complement complexes nor immunocompetent cells could be demonstrated in these healthy tissues. Gram‐stained sections of samples from diseased sites showed large numbers of bacteria and inflammatory cells in gingival plaque and penetration of bacteria into the gingival tissue accompanied by inflammation. Wherever the areas of bacterial colonisation or of antigen penetration were large enough to cut three sequential sections, bacteria and bacterial antigens could be demonstrated in complexes with specific antibody and complement. A unique aspect of the present study was the demonstration that penetrating bacteria were always associated with antibodies and frequently also with complement. A. viscosus, A. naeslundii, and B. gingivalis or their Ags were found in almost equal numbers of gingival samples complexed with specific Abs; B. melaninogenicus ss. intermedius was present in a much lower number of samples. However, A. viscosus was found in larger deposits complexed with specific Abs, i.e. more sections per sample, followed by B. gingivalis. A. naeslundii and B. melaninogenicus ss. intermedius were both found in the lowest number of sections per sample. Similarly. A. viscosus was found in the largest deposits of antigen‐antibody‐complement complexes, followed by B. gingivalis and A. naeslundii. B. melaninogenicus ss. intermedius was not found in complexes with complement. In the gingival plaque and in the gingival tissues all the reactants for a cytotoxic type of immunopathological reaction could be demonstrated. Plasma cells were identified in the tissues mainly in the lamina propria. T‐cells were identified, but only in deeper connective tissues.

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Section: Discussionmentioning

confidence: 99%

Identification of bacteria in immunopathological mechanisms of human periodontal diseases

Pekovic

Fillery

1984

J of Periodontal Research

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“…Case reports indicate that ulcerations of the marginal gingiya are a common finding in patients with abnormal neutrophils. It has been suggested that these lesions are a consequence of bacterial invasion into the tissue (Telsey et al 1962, Wade & Stafford 1963, Gates 1969). In the preserit study neither ulcerations of the marginal gingiva nor gross bacterial invasion in the gingival tissues were observed.…”

Section: Discussionmentioning

confidence: 99%

Influence of experimental neutropenia in dogs with chronic gingivitis

Rylander¹,

Attström²,

Lindhe³

1975

J of Periodontal Research

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The influence of a four day period of experimental neutropenia on the clinical state and the structural constituents of chronically inflamed gingiva has been studied in four beagle dogs. Neutropenia was induced by heterologous anti‐neutrophil serum. The effects on the gingiva were evaluated by Gingival Index (GI) and Gingival Exudate measurements and by morphometric analysis of various tissue components in sections from biopsies of buccal gingiva sampled on days 2, 3, and 4. Control biopsies were obtained before induction of neutropenia. The GI did not markedly change during the observation period. The amount of Gingival Exudate, however, significantly decreased following the induction of neutropenia and remained low throughout the experiment. Neutrophilic granulocytes disappeared in the gingival tissues, while, apart from a relative increase in plasma cells, no other tissue components seemed to change. No bacterial invasion of the junctional epithelium or of the gingival connective tissue could be observed. Thus during a four day period the bacterial defense mechanisms at the dentogingival junction seem to be able to prevent penetration of microorganisms into the gingival tissues despite the absence of neutrophilic granulocytes.

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Periodontosis with periodontitis: A study involving young adult males

Kaslick

Chasens

1968

Oral Surgery, Oral Medicine, Oral Pathology

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Oral manifestations of cyclical neutropenia associated with hypergammaglobulinemia

Cited by 12 publications

References 5 publications

Identification of bacteria in immunopathological mechanisms of human periodontal diseases

Identification of bacteria in immunopathological mechanisms of human periodontal diseases

Influence of experimental neutropenia in dogs with chronic gingivitis

Periodontosis with periodontitis: A study involving young adult males

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