Oral manifestations of neurofibromatosis types I and II

Geist, James R.; Gander, D L; Stefanac, Stephen J.

doi:10.1016/0030-4220(92)90139-h

Cited by 57 publications

(49 citation statements)

References 25 publications

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“…6 ( Tables 1,2) Pigmented lesions, one of the most common manifestations of NF1, are often present at birth or may appear during the first years of life. 2,6,7 These pigmented lesions appear as café-au-lait spots and freckles. 7 Café-au-lait spots are smoothedged pigmented macules and their colour varies from yellowish to chocolate-brown.…”

Section: Discussionmentioning

confidence: 99%

“…2,6,7 These pigmented lesions appear as café-au-lait spots and freckles. 7 Café-au-lait spots are smoothedged pigmented macules and their colour varies from yellowish to chocolate-brown. Their distribution is random over the body except for a disproportionately small number on the face.…”

Section: Discussionmentioning

confidence: 99%

“…1 Freckles in the axillary or inguinal areas are very common and are referred to as Crowe's sign. 7 In some patients with NF1, freckling may occur diffusely over the trunk, extremities, upper eyelids and base of the neck. 2 Our patient exhibited five café-au-lait spots and freckles over her back and in the axillary region (Crowe's sign).…”

Section: Discussionmentioning

confidence: 99%

“…However, bony defects may arise from mesodermal dysplasia unrelated to the proximity of the neural lesion. 7 Plexiform neurofibroma on the face can also cause facial asymmetry. Exophthalmia caused by sphenoid wing dysplasia can also be present.…”

Section: Discussionmentioning

confidence: 99%

“…10 In the past, the frequency of oral manifestations of NF1 was estimated to occur in 4 to 7% of all cases. 7,11 However, two studies suggested that oral manifestations are much higher. 4,10 The low frequency of oral manifestations in certain studies can be explained by the lack of radiographic examinations, ignoring the intraosseous manifestations.…”

Section: Discussionmentioning

confidence: 99%

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Neurofibromatosis type I with periodontal manifestation. A case report and literature review

et al. 2004

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The term neurofibromatosis (NF) is used for a group of genetic disorders that primarily affect the cell growth of neural tissues. Neurofibromatosis type 1 (NF1), also known as von Recklinghausen´s disease, is the most common type of NF and accounts for about 90% of all cases. It is one of the most frequent human genetic diseases, with a prevalence of one case in 3,000 births. The expressivity of NF1 is extremely variable, with manifestations ranging from mild lesions to several complications and functional impairment. Oral manifestations can be found in almost 72% of NF1 patients. A case of a NF1 patient with a gingival neurofibroma in the attached gingiva of the lingual aspect of the lower central incisors is presented. The lesion was nodular, with sessile base, non-ulcerated, non-painful, with normal colour and measured 1 cm in diameter. An excisional biopsy of the oral lesion was performed. Histopathological and immunohistochemical analysis confirmed the clinical hypothesis of neurofibroma. Because NF1 is one of the most common genetic diseases and oral manifestations are very common, dentists should be aware of the characteristics of this disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Neurofibromatosis type I with periodontal manifestation. A case report and literature review

et al. 2004

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The Oral Cavity and Lips

Scully

2004

Rook's Textbook of Dermatology

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Dermatoses of the Oral Cavity and Lips

Scully¹

2016

Rook's Textbook of Dermatology, Ninth Edition

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Oral and labial lesions are usually the result of local disease but may be the early signs of systemic disease, including dermatological disorders, and in some instances may cause the main symptoms. This chapter mainly discusses disorders of the periodontal and mucosal tissues that may be related to skin disease and that may present at a dermatology clinic. It should be borne in mind that the professionals most competent in diagnosing and treating oral diseases are those with formal dental training and who are therefore in a position to understand the full complexities of the region. This chapter is divided into a brief discussion of the biology of the mouth, an overview of the more common signs and symptoms affecting specific oral tissues, discussion of the disorders of the oral mucosa of most relevance to dermatology and a tabulated review of oral manifestations of systemic diseases. Only the more classic oral lesions are illustrated. For reasons of space restrictions, diseases affecting the teeth, salivary glands, jaws or temporomandibular joints are not discussed in any depth.

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Oral manifestations of neurofibromatosis types I and II

Cited by 57 publications

References 25 publications

Neurofibromatosis type I with periodontal manifestation. A case report and literature review

Neurofibromatosis type I with periodontal manifestation. A case report and literature review

The Oral Cavity and Lips

Dermatoses of the Oral Cavity and Lips

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