Oral manifestations of thrombocytopaenia

Abstract

The appearance in the mouth of haemorrhagic petechiae, ecchymoses or blood blisters with spontaneous bleeding is suggestive of a haemorrhagic disorder that may be caused either by functional impairment of platelets or of blood vessel walls, by an abnormal decrease in the number of circulating platelets (thrombocytopaenia), or by defects in the blood clotting mechanism. Thrombocytopaenia from decreased production or increased destruction of platelets may be caused by multiple factors including immune mediated mechanisms, drugs or infections. A diagnosis of thrombocytopaenic purpura can be made when any other disease entity that might be causing the purpura is excluded on the basis of the medical history, the physical examination, a complete blood count and a peripheral blood smear. In this paper, we outline the clinical features of oral thrombocytopaenic purpura and briefly discuss some aspects of its aetiopathogenesis and treatment.

Angina Bullosa Hemorrhagica: A Rare Presentation of Oral Bleeding

“…The diagnosis of ABH is primarily a diagnosis of exclusion, which is arrived at after eliminating the possibilities of other disorders that might present with similar complaints, such as thrombocytopenia, Behcet’s disease, and von Willebrand disease [ 13 - 15 ]. Therefore, it is crucial to order blood investigations to check for any abnormalities in the blood picture in terms of platelet count, bleeding time, clotting time, and other such hematological parameters, which in this patient turned out to be normal.…”

Arzneimittelexantheme auf der Haut und der Schleimhaut – Teil I

“…2). Thrombozytopenien werden nach der Zahl der Thrombozyten im peripheren Blut in verschiedene Formen unterteilt: mild (100-150 × 10 3 (mm 3 ), moderat (50-100 × 10 3 (mm 3 ), schwer (30-50 × 10 3 (mm 3 ) und lebensbedrohlich (< 30 × 10 3 (mm 3 ) [7].…”

Terapi Imunosupresan Pada Pasien Anemia Aplastik Dengan Perdarahan Gusi: Menyembuhkan Atau Memperparah?

“…4 Trombositopenia didefinisikan sebagai kondisi dengan jumlah trombosit dibawah 150.000/mm 3 . 5,6 Manifestasi oral yang sering terjadi pada kondisi trombositopenia yaitu adanya satu atau lebih petekie hemoragik serta perdarahan spontan pada gingiva. 5 Tatalaksana AA pada dasarnya terdiri dari 3 yaitu: transplantasi sel punca, terapi imunosupresif (IST) dan perawatan suportif.…”

“…5,6 Manifestasi oral yang sering terjadi pada kondisi trombositopenia yaitu adanya satu atau lebih petekie hemoragik serta perdarahan spontan pada gingiva. 5 Tatalaksana AA pada dasarnya terdiri dari 3 yaitu: transplantasi sel punca, terapi imunosupresif (IST) dan perawatan suportif. IST menjadi pengobatan standar untuk AA khususnya pada pasien yang tidak dapat dilakukan SCT, 3,7,8 dengan antithmyocyte globulin (ATG), antilymphocyte globulin (ALG) dan cyclosporine (CsA) merupakan pilihan yang sering digunakan dengan keberhasilan sekitar 50-60%.…”