Oral Melanoacanthoma: Case Series of 33 Cases and Review of the Literature

Abed, Dr. Shawki; Fitzpatrick, Sarah; Bhattacharyya, Indraneel; Islam, Mohammed N.; Cohen, Donald M.

doi:10.1007/s12105-022-01506-w

Cited by 4 publications

(11 citation statements)

References 17 publications

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“…The previously published immunohistochemical profile of OMA is limited and includes a strong reactivity to HMB-45, S100, and melan-A. 3,[16][17][18] The Ki-67 labeling was reported for a single case of OMA, with proliferating cells limited to the basal and suprabasal epithelial layers. 18 TRP2 is critical for melanin production, affecting the quantity and quality of melanin.…”

Section: Discussionmentioning

confidence: 99%

“…Table S3 shows the clinical characteristics of the 85 cases included in the scoping review. Other 47 cases were published in three articles, 3,11,12 but in a summarized manner that impaired data extraction and inclusion in the scoping review. The results of those three studies may be summarized as follows.…”

Section: Case Seriesmentioning

confidence: 99%

“…Oral melanoacanthoma (OMA) is a rare benign pigmented lesion. [1][2][3] The World Health Organization (WHO) included OMA in its 2022 classification of tumors as a non-neoplastic lesion distinct from its cutaneous counterpart, showing rapid growth but indolent behavior. 2 OMA usually presents as a solitary brown-black macular lesion, although multiple lesions may rarely appear.…”

Section: Introductionmentioning

confidence: 99%

“…9 As OMA, it shows a benign proliferation of keratinocytes and melanocytes, but the clinical aspect is usually of a growing nodule covered by an irregular surface which can mimic melanoma features in some cases. 3,9,10 Considering the rarity and controversies about OMA, the description of the clinical and microscopic characteristics of new cases of OMA can aid the comprehension of the nature and behavior of this lesion. Therefore, the present study aims to present the clinical, histopathological, and immunohistochemical features of a case series of OMA, as well as the previously published cases of OMA.…”

Section: Introductionmentioning

confidence: 99%

“…The cutaneous melanoacanthoma is considered a benign tumor, usually classified as a variant of seborrheic keratosis 9 . As OMA, it shows a benign proliferation of keratinocytes and melanocytes, but the clinical aspect is usually of a growing nodule covered by an irregular surface which can mimic melanoma features in some cases 3,9,10 …”

Section: Introductionmentioning

confidence: 99%

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Oral melanoacanthoma: Clinicopathological and immunohistochemical features of a case series and a scoping review

Tavares,

da Costa,

da Mata Camargos

et al. 2023

J Oral Pathology Medicine

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BackgroundThis study presents a case series and scoping review of oral melanoacanthoma to examine its clinical, histopathological, and immunohistochemical characteristics.MethodsNine cases of oral melanoacanthoma were included in the case series. Clinical data were collected from biopsy charts. Hematoxylin–eosin and immunohistochemistry for TRP2, CD3, and CD20 were done. For the scoping review, MEDLINE/PubMed, Web of Science, EMBASE, and Scopus were searched.ResultsCase series: The mean age was 46.8 years (female‐to‐male ratio 2:1). Lesion's mean size was 11.0 mm (±9.3). Lesions were mainly macular (77.8%) with brown or black coloration (88.9%) and often affected multiple sites (44.4%). The evolution time ranged from 15 days to 96 months. Lesions commonly showed epithelial acanthosis (66.7%), spongiosis (55.6%), exocytosis (77.8%), melanin incontinence (88.9%), and inflammatory infiltrate in the lamina propria (77.8%), from which all showed lymphocytes. TRP2‐positive melanocytes were identified in the basal and spinous layer of all cases, and in the superficial layer of three cases. CD3‐positive cells predominate over the CD20‐positive. Scoping review: 85 cases of oral melanoacanthoma were retrieved from 55 studies. Patients were primarily female (female‐to‐male ratio 2.2:1), black‐skinned (64.1%), with a mean age of 36.13 (± 17.24). Lesions were flat (81.9%), often brown (62.4%). Buccal mucosa was the preferred site (32.9%), followed by multiple sites (28.2%).ConclusionOral melanoacanthoma mainly affects women across a wide age range, with lesions commonly appearing as brown/black macules, particularly on the buccal mucosa. TRP2‐positive melanocytes and T‐lymphocytes were consistently found and could participate in oral melanoacanthoma pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Section: Case Seriesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Oral melanoacanthoma: Clinicopathological and immunohistochemical features of a case series and a scoping review

Tavares,

da Costa,

da Mata Camargos

et al. 2023

J Oral Pathology Medicine

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Multifocal pigmented lesions in the maxilla

Heifetz-Li,

Smith,

Roche

2024

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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A graphite foreign body granuloma that caused palatal perforation. Case report and literature review

Tosiou,

Kalogirou,

Tosios

et al. 2024

Preprint

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Introduction: We present an unusual case of a graphite foreign body granuloma causing palatal perforation. Case description: A 62-year-old female presented with a macule on the hard palate clinically consistent with a blue nevus. On biopsy a black nodular mass was excised, establishing oroantral communication that was verified by a computed tomography scan. A diagnosis of malignant melanoma was strongly suspected, but microscopic examination showed a graphite foreign body granuloma. It was suggested that the graphite was implanted in a thin area of the palatal bone causing perforation. Conclusion: Graphite tattoos should be excised, both for diagnostics purposes and the possibility of causing tissue destruction by generating a foreign body granuloma reaction.

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Oral Melanoacanthoma: Case Series of 33 Cases and Review of the Literature

Cited by 4 publications

References 17 publications

Oral melanoacanthoma: Clinicopathological and immunohistochemical features of a case series and a scoping review

Oral melanoacanthoma: Clinicopathological and immunohistochemical features of a case series and a scoping review

Multifocal pigmented lesions in the maxilla

A graphite foreign body granuloma that caused palatal perforation. Case report and literature review

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