Oral Methylated N-Aryl Chitosan Derivatives for Inducing Immune Responses to Ovalbumin

Suksamran, Tittaya; Kowapradit, Jariya; Ngawhirunpat, Tanasait; Rojanarata, Theerasak; Sajomsang, Warayuth; Pitaksuteepong, Tasana; Opanasopit, Praneet

doi:10.4314/tjpr.v11i6.5

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…Methylated N-Aryl CS Derivatives An enhanced agent for in vitro paracellular permeation and in vivo adjuvant activity post oral administration to mice. Suksamran et al [185] Quaternary CS magnetic composite modified with ammonium salt and combined with iron (II and III) oxide (Fe 3 O 4 ) nanoparticles A pH-dependent bioadsorption agent for methyl orange and chromium (VI) with homogeneous monolayer chemisorption behavior process.…”

Section: Cs Derivatives Application Referencementioning

confidence: 99%

Chitosan Nanoparticle-Based System: A New Insight into the Promising Controlled Release System for Lung Cancer Treatment

Kuen

2022

Molecules

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Lung cancer has been recognized as one of the most often diagnosed and perhaps most lethal cancer diseases worldwide. Conventional chemotherapy for lung cancer-related diseases has bumped into various limitations and challenges, including non-targeted drug delivery, short drug retention period, low therapeutic efficacy, and multidrug resistance (MDR). Chitosan (CS), a natural polymer derived from deacetylation of chitin, and comprised of arbitrarily distributed β-(1-4)-linked d-glucosamine (deacetylated unit) and N-acetyl-d-glucosamine (acetylated unit) that exhibits magnificent characteristics, including being mucoadhesive, biodegradable, and biocompatible, has emerged as an essential element for the development of a nano-particulate delivery vehicle. Additionally, the flexibility of CS structure due to the free protonable amino groups in the CS backbone has made it easy for the modification and functionalization of CS to be developed into a nanoparticle system with high adaptability in lung cancer treatment. In this review, the current state of chitosan nanoparticle (CNP) systems, including the advantages, challenges, and opportunities, will be discussed, followed by drug release mechanisms and mathematical kinetic models. Subsequently, various modification routes of CNP for improved and enhanced therapeutic efficacy, as well as other restrictions of conventional drug administration for lung cancer treatment, are covered.

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Section: Cs Derivatives Application Referencementioning

confidence: 99%

Chitosan Nanoparticle-Based System: A New Insight into the Promising Controlled Release System for Lung Cancer Treatment

Kuen

2022

Molecules

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“…In addition, methylated N -(4- N , N -dimethylaminobenzyl) chitosan (TMBC), methylated N -(4- N , N -dimethylaminocinnamyl) chitosan (TMCC) and methylated N -(4-pyridinylmethyl) chitosan (TMPC) were also prepared to deliver ovalbumin (OVA) for oral vaccination. The results indicated that the TMCC showed the most efficient immune response [ 37 ]. The OVA-loaded MPs coated with TMCC by electrospray exhibited the highest in vivo adjuvant activity in both IgG and IgA immunogenicity through oral vaccination.…”

Section: Chemical Modificationmentioning

confidence: 99%

Chemical Modification of Chitosan for Efficient Vaccine Delivery

et al. 2018

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Chitosan, which exhibits good biocompatibility, safety, microbial degradation and other excellent performances, has found application in all walks of life. In the field of medicine, usage of chitosan for the delivery of vaccine is favored by a wide range of researchers. However, due to its own natural limitations, its application has been constrained to the beginning of study. In order to improve the applicability for vaccine delivery, researchers have carried out various chemical modifications of chitosan. This review summarizes a variety of modification methods and applications of chitosan and its derivatives in the field of vaccine delivery.

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“…These side-effects greatly decrease their immunotherapeutic efficacy and limit their clinical applications against tumors. 6,7 Thus the key issues in the stimulation of cellular immunity against tumor cells is developing new carrier materials: 8 (1) to protect the protein-based antigens/vaccines against rapid biodegradation or absorption in the bloodstream; and (2) to control the antigen processing of the vaccines inside antigen-presenting cells (APCs) through the major histocompatibility complex (MHC) I pathway.…”

Section: Introductionmentioning

confidence: 99%

Hydrophobic chain modified low molecular weight polyethylenimine for efficient antigen delivery

et al. 2016

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Oral Methylated N-Aryl Chitosan Derivatives for Inducing Immune Responses to Ovalbumin

Abstract: Purpose: To investigate different structures of modified chitosan containing different chain lengths and aromatic moieties for vaccine delivery capacity. Methods:The characteristics of the modified chitosan, namely,Ndimethylaminobenzyl) chitosan chitosan

Cited by 4 publications

References 20 publications

Chitosan Nanoparticle-Based System: A New Insight into the Promising Controlled Release System for Lung Cancer Treatment

Chitosan Nanoparticle-Based System: A New Insight into the Promising Controlled Release System for Lung Cancer Treatment

Chemical Modification of Chitosan for Efficient Vaccine Delivery

Hydrophobic chain modified low molecular weight polyethylenimine for efficient antigen delivery

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